6n0b - Revision history

OCA at 06:42, 11 October 2023

OCA — Wed, 11 Oct 2023 06:42:32 GMT

←Older revision		Revision as of 06:42, 11 October 2023
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	<StructureSection load='6n0b' size='340' side='right'caption='[[6n0b]], [[Resolution\|resolution]] 1.74Å' scene=''>		<StructureSection load='6n0b' size='340' side='right'caption='[[6n0b]], [[Resolution\|resolution]] 1.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n0b]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N0B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N0B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n0b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N0B FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.739Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Related_structure~~\|~~Related:]]</b></td><td class="sblockDat">[[3tw4\|3tw4~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SEPT7, CDC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n0b OCA], [https://pdbe.org/6n0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n0b RCSB], [https://www.ebi.ac.uk/pdbsum/6n0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n0b ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n0b OCA], [~~http~~://pdbe.org/6n0b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6n0b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6n0b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6n0b ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SEPT7_HUMAN SEPT7_HUMAN]] Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements.<ref>PMID:17803907</ref> <ref>PMID:18460473</ref>	+	[https://www.uniprot.org/uniprot/SEPT7_HUMAN SEPT7_HUMAN] Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements.<ref>PMID:17803907</ref> <ref>PMID:18460473</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Araujo~~, A P.U~~]]	+	[[Category: Araujo APU]]
-	[[Category: Brandao-Neto, J]]	+	[[Category: Brandao-Neto J]]
-	[[Category: Brognara, G]]	+	[[Category: Brognara G]]
-	[[Category: Garratt~~, R C~~]]	+	[[Category: Garratt RC]]
-	[[Category: Pereira~~, H M]]~~	+	[[Category: Pereira HM]]
-	~~[[Category: Cytoskeleton component septin gtpase]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 06:32, 19 June 2019

OCA — Wed, 19 Jun 2019 06:32:23 GMT

←Older revision		Revision as of 06:32, 19 June 2019
Line 3:		Line 3:
	<StructureSection load='6n0b' size='340' side='right'caption='[[6n0b]], [[Resolution\|resolution]] 1.74Å' scene=''>		<StructureSection load='6n0b' size='340' side='right'caption='[[6n0b]], [[Resolution\|resolution]] 1.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n0b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N0B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n0b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N0B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tw4\|3tw4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tw4\|3tw4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SEPT7, CDC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n0b OCA], [http://pdbe.org/6n0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n0b RCSB], [http://www.ebi.ac.uk/pdbsum/6n0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n0b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n0b OCA], [http://pdbe.org/6n0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n0b RCSB], [http://www.ebi.ac.uk/pdbsum/6n0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n0b ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Araujo, A P.U]]		[[Category: Araujo, A P.U]]

OCA at 08:53, 1 May 2019

OCA — Wed, 01 May 2019 08:53:38 GMT

←Older revision		Revision as of 08:53, 1 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6n0b is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of GTPase Domain of Human Septin 7 at High Resolution==
		+	<StructureSection load='6n0b' size='340' side='right'caption='[[6n0b]], [[Resolution\|resolution]] 1.74Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6n0b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N0B FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tw4\|3tw4]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n0b OCA], [http://pdbe.org/6n0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n0b RCSB], [http://www.ebi.ac.uk/pdbsum/6n0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n0b ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SEPT7_HUMAN SEPT7_HUMAN]] Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements.<ref>PMID:17803907</ref> <ref>PMID:18460473</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Septins are GTP-binding proteins that will often spontaneously assemble into filaments. In some species, particularly budding yeast, it is well known that these are capable of associating with membranes in order to fulfill their cellular role as a component of the cytoskeleton. Different from other human septins, SEPT7 appears to be unique in that it is an essential component of all hetero-oligomeric complexes described to date. As a step towards understanding the molecular basis of filament assembly, here we present two high-resolution structures of the SEPT7 GTPase domain complexed with GDP. One of these reveals a previously unreported coordination for the magnesium ion involving four water molecules and only a tenuous connection to the protein. The higher resolution structures provide unambiguous insight into the interactions at the G-interface where a structural motif based on an antiparallel beta-bridge allows for the rationalization of why some septins show nucleotide-dependent beta-strand slippage and others do not.

-	~~Authors: Brognara~~, G., Pereira~~, H.M.~~, Brandao-Neto, J., Araujo, A.P.U., ~~Garratt, R~~.C.	+	Revisiting SEPT7 and the slippage of beta-strands in the septin family.,Brognara G, Pereira HM, Brandao-Neto J, Araujo APU, Garratt RC J Struct Biol. 2019 Apr 19. pii: S1047-8477(19)30081-4. doi:, 10.1016/j.jsb.2019.04.015. PMID:31009756<ref>PMID:31009756</ref>

-	~~Description: Structure~~ of ~~GTPase Domain~~ of ~~Human Septin 7 at High Resolution~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Araujo, A.P.U]]	+	<div class="pdbe-citations 6n0b" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Araujo, A P.U]]
	[[Category: Brandao-Neto, J]]		[[Category: Brandao-Neto, J]]
-	[[Category: Garratt, R.C]]
-	[[Category: Pereira, H.M]]
	[[Category: Brognara, G]]		[[Category: Brognara, G]]
		+	[[Category: Garratt, R C]]
		+	[[Category: Pereira, H M]]
		+	[[Category: Cytoskeleton component septin gtpase]]
		+	[[Category: Structural protein]]

OCA at 05:17, 12 December 2018

OCA — Wed, 12 Dec 2018 05:17:47 GMT

←Older revision		Revision as of 05:17, 12 December 2018
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	The entry 6n0b is ON HOLD until Paper Publication		The entry 6n0b is ON HOLD until Paper Publication

-	Authors: Brognara, G., Pereira, H.M., Brandao-Neto, J., ~~Ulian~~, A.P.U., Garratt, R.C.	+	Authors: Brognara, G., Pereira, H.M., Brandao-Neto, J., Araujo, A.P.U., Garratt, R.C.

	Description: Structure of GTPase Domain of Human Septin 7 at High Resolution		Description: Structure of GTPase Domain of Human Septin 7 at High Resolution
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Araujo, A.P.U]]
	[[Category: Brandao-Neto, J]]		[[Category: Brandao-Neto, J]]
	[[Category: Garratt, R.C]]		[[Category: Garratt, R.C]]
	[[Category: Pereira, H.M]]		[[Category: Pereira, H.M]]
-	[[Category: Ulian, A.P.U]]
	[[Category: Brognara, G]]		[[Category: Brognara, G]]

OCA at 19:06, 2 December 2018

OCA — Sun, 02 Dec 2018 19:06:00 GMT

←Older revision		Revision as of 19:06, 2 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n0b is ON HOLD	+	The entry 6n0b is ON HOLD until Paper Publication

	Authors: Brognara, G., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C.		Authors: Brognara, G., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C.

OCA: Protected "6n0b" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2018 06:45:39 GMT

Protected "6n0b" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:45, 14 November 2018

OCA: New page: '''Unreleased structure''' The entry 6n0b is ON HOLD Authors: Brognara, G., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C. Description: Structure of GTPase Domain of Hum...

OCA — Wed, 14 Nov 2018 06:45:38 GMT

New page: '''Unreleased structure''' The entry 6n0b is ON HOLD Authors: Brognara, G., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C. Description: Structure of GTPase Domain of Hum...

New page

'''Unreleased structure'''

The entry 6n0b is ON HOLD

Authors: Brognara, G., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C.

Description: Structure of GTPase Domain of Human Septin 7 at High Resolution
[[Category: Unreleased Structures]]
[[Category: Brandao-Neto, J]]
[[Category: Garratt, R.C]]
[[Category: Pereira, H.M]]
[[Category: Ulian, A.P.U]]
[[Category: Brognara, G]]