6n27 - Revision history

OCA at 03:05, 11 April 2020

OCA — Sat, 11 Apr 2020 03:05:54 GMT

←Older revision		Revision as of 03:05, 11 April 2020
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	<SX load='6n27' size='340' side='right' viewer='molstar' caption='[[6n27]], [[Resolution\|resolution]] 3.00Å' scene=''>		<SX load='6n27' size='340' side='right' viewer='molstar' caption='[[6n27]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n27]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N27 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n27]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N27 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6N27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6n23\|6n23]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6n23\|6n23]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BEST1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BEST1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n27 OCA], [http://pdbe.org/6n27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n27 RCSB], [http://www.ebi.ac.uk/pdbsum/6n27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n27 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6n27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n27 OCA], [http://pdbe.org/6n27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n27 RCSB], [http://www.ebi.ac.uk/pdbsum/6n27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n27 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:41, 6 March 2020

OCA — Fri, 06 Mar 2020 22:41:38 GMT

←Older revision		Revision as of 22:41, 6 March 2020
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	==BEST1 calcium-bound closed state==		==BEST1 calcium-bound closed state==
-	<~~StructureSection~~ load='6n27' size='340' side='right'caption='[[6n27]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<SX load='6n27' size='340' side='right' viewer='molstar' caption='[[6n27]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6n27]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6n27]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N27 FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Chick]]		[[Category: Chick]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 10:28, 4 December 2019

OCA — Wed, 04 Dec 2019 10:28:34 GMT

←Older revision		Revision as of 10:28, 4 December 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6n27 is ~~ON HOLD until Paper~~ Publication	+	==BEST1 calcium-bound closed state==
		+	<StructureSection load='6n27' size='340' side='right'caption='[[6n27]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6n27]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N27 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6n23\|6n23]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BEST1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n27 OCA], [http://pdbe.org/6n27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n27 RCSB], [http://www.ebi.ac.uk/pdbsum/6n27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n27 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bestrophin (BEST1-4) ligand-gated chloride (Cl(-)) channels are activated by calcium (Ca(2+)). Mutation of BEST1 causes retinal disease. Partly because bestrophin channels have no sequence or structural similarity to other ion channels, the molecular mechanisms underlying gating are unknown. Here, we present a series of cryo-electron microscopy structures of chicken BEST1, determined at 3.1 A resolution or better, that represent the channel's principal gating states. Unlike other channels, opening of the pore is due to the repositioning of tethered pore-lining helices within a surrounding protein shell that dramatically widens a neck of the pore through a concertina of amino acid rearrangements. The neck serves as both the activation and the inactivation gate. Ca(2+) binding instigates opening of the neck through allosteric means whereas inactivation peptide binding induces closing. An aperture within the otherwise wide pore controls anion permeability. The studies define a new molecular paradigm for gating among ligand-gated ion channels.

-	~~Authors~~:	+	Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin.,Miller AN, Vaisey G, Long SB Elife. 2019 Jan 10;8. pii: 43231. doi: 10.7554/eLife.43231. PMID:30628889<ref>PMID:30628889</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6n27" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chick]]
		+	[[Category: Large Structures]]
		+	[[Category: Long, S B]]
		+	[[Category: Miller, A N]]
		+	[[Category: Vaisey, G]]
		+	[[Category: Anion channel]]
		+	[[Category: Calcium activated chloride channel]]
		+	[[Category: Eukaryotic membrane protein]]
		+	[[Category: Ion channel]]
		+	[[Category: Ligand gated ion channel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transport protein]]

OCA at 10:32, 16 January 2019

OCA — Wed, 16 Jan 2019 10:32:30 GMT

←Older revision		Revision as of 10:32, 16 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n27 is ON HOLD	+	The entry 6n27 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6n27" [edit=sysop:move=sysop]

OCA — Sun, 02 Dec 2018 19:08:49 GMT

Protected "6n27" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:08, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n27 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Sun, 02 Dec 2018 19:08:47 GMT

New page: '''Unreleased structure''' The entry 6n27 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6n27 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]