6n3u - Revision history

OCA at 09:15, 25 October 2023

OCA — Wed, 25 Oct 2023 09:15:29 GMT

←Older revision		Revision as of 09:15, 25 October 2023
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	<StructureSection load='6n3u' size='340' side='right'caption='[[6n3u]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='6n3u' size='340' side='right'caption='[[6n3u]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n3u]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N3U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n3u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N3U FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~gag (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=11676 9HIV1])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3u OCA], [~~http~~://pdbe.org/6n3u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6n3u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6n3u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3u OCA], [https://pdbe.org/6n3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n3u RCSB], [https://www.ebi.ac.uk/pdbsum/6n3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3u ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GAG_HV1H2 GAG_HV1H2] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chrustowicz, J]]	+	[[Category: Chrustowicz J]]
-	[[Category: Hattne, J]]	+	[[Category: Hattne J]]
-	[[Category: Purdy~~, M D~~]]	+	[[Category: Purdy MD]]
-	[[Category: Shi, D]]	+	[[Category: Shi D]]
-	~~[[Category: Bevirimat]]~~	+
-	~~[[Category: Hiv-1 gag]]~~	+
-	~~[[Category: Immature hexagonal lattice]]~~	+
-	~~[[Category: Microed]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 17:35, 20 November 2019

OCA — Wed, 20 Nov 2019 17:35:41 GMT

←Older revision		Revision as of 17:35, 20 November 2019
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	==MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag with bound maturation inhibitor Bevirimat.==		==MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag with bound maturation inhibitor Bevirimat.==
-	<StructureSection load='6n3u' size='340' side='right' caption='[[6n3u]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='6n3u' size='340' side='right'caption='[[6n3u]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6n3u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3U FirstGlance]. <br>		<table><tr><td colspan='2'>[[6n3u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3U FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 6n3u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6n3u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chrustowicz, J]]		[[Category: Chrustowicz, J]]
	[[Category: Hattne, J]]		[[Category: Hattne, J]]

OCA at 08:47, 26 December 2018

OCA — Wed, 26 Dec 2018 08:47:51 GMT

←Older revision		Revision as of 08:47, 26 December 2018
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3u OCA], [http://pdbe.org/6n3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3u RCSB], [http://www.ebi.ac.uk/pdbsum/6n3u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3u OCA], [http://pdbe.org/6n3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3u RCSB], [http://www.ebi.ac.uk/pdbsum/6n3u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3u ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	HIV-1 protease (PR) cleavage of the Gag polyprotein triggers the assembly of mature, infectious particles. Final cleavage of Gag occurs at the junction helix between the capsid protein CA and the SP1 spacer peptide. Here we used MicroED to delineate the binding interactions of the maturation inhibitor bevirimat (BVM) using very thin frozen-hydrated, 3D microcrystals of a CTD-SP1 Gag construct with and without bound BVM. The 2.9-A MicroED structure revealed that a single BVM molecule stabilizes the six-helix bundle via both electrostatic interactions with the dimethylsuccinyl moiety and hydrophobic interactions with the pentacyclic triterpenoid ring. These results provide insight into the mechanism of action of BVM and related maturation inhibitors that will inform further drug discovery efforts. This study also demonstrates the capabilities of MicroED for structure-based drug design.
		+
		+	MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat.,Purdy MD, Shi D, Chrustowicz J, Hattne J, Gonen T, Yeager M Proc Natl Acad Sci U S A. 2018 Dec 10. pii: 1806806115. doi:, 10.1073/pnas.1806806115. PMID:30530702<ref>PMID:30530702</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6n3u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:09, 19 December 2018

OCA — Wed, 19 Dec 2018 09:09:15 GMT

←Older revision		Revision as of 09:09, 19 December 2018
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	<StructureSection load='6n3u' size='340' side='right' caption='[[6n3u]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='6n3u' size='340' side='right' caption='[[6n3u]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n3u]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n3u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3u OCA], [http://pdbe.org/6n3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3u RCSB], [http://www.ebi.ac.uk/pdbsum/6n3u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3u ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3u OCA], [http://pdbe.org/6n3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3u RCSB], [http://www.ebi.ac.uk/pdbsum/6n3u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3u ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 06:59, 12 December 2018

OCA — Wed, 12 Dec 2018 06:59:08 GMT

←Older revision		Revision as of 06:59, 12 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6n3u is ~~ON HOLD~~	+	==MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag with bound maturation inhibitor Bevirimat.==
-		+	<StructureSection load='6n3u' size='340' side='right' caption='[[6n3u]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6n3u]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3U FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3u OCA], [http://pdbe.org/6n3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3u RCSB], [http://www.ebi.ac.uk/pdbsum/6n3u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3u ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chrustowicz, J]]
		+	[[Category: Hattne, J]]
		+	[[Category: Purdy, M D]]
		+	[[Category: Shi, D]]
		+	[[Category: Bevirimat]]
		+	[[Category: Hiv-1 gag]]
		+	[[Category: Immature hexagonal lattice]]
		+	[[Category: Microed]]
		+	[[Category: Viral protein]]

OCA: Protected "6n3u" [edit=sysop:move=sysop]

OCA — Sun, 02 Dec 2018 19:13:48 GMT

Protected "6n3u" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:13, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n3u is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Sun, 02 Dec 2018 19:13:46 GMT

New page: '''Unreleased structure''' The entry 6n3u is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6n3u is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]