6n4b - Revision history

OCA at 03:08, 11 April 2020

OCA — Sat, 11 Apr 2020 03:08:15 GMT

←Older revision		Revision as of 03:08, 11 April 2020
Line 3:		Line 3:
	<SX load='6n4b' size='340' side='right' viewer='molstar' caption='[[6n4b]], [[Resolution\|resolution]] 3.00Å' scene=''>		<SX load='6n4b' size='340' side='right' viewer='molstar' caption='[[6n4b]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n4b]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N4B OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N4B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n4b]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N4B OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6N4B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KCA:methyl+N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate'>KCA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KCA:methyl+N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate'>KCA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CNR1, CNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CNR1, CNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n4b OCA], [http://pdbe.org/6n4b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n4b RCSB], [http://www.ebi.ac.uk/pdbsum/6n4b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n4b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6n4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n4b OCA], [http://pdbe.org/6n4b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n4b RCSB], [http://www.ebi.ac.uk/pdbsum/6n4b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n4b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:45, 6 March 2020

OCA — Fri, 06 Mar 2020 22:45:49 GMT

←Older revision		Revision as of 22:45, 6 March 2020
Line 1:		Line 1:

	==Cannabinoid Receptor 1-G Protein Complex==		==Cannabinoid Receptor 1-G Protein Complex==
-	<~~StructureSection~~ load='6n4b' size='340' side='right'caption='[[6n4b]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<SX load='6n4b' size='340' side='right' viewer='molstar' caption='[[6n4b]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6n4b]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N4B FirstGlance]. <br>		<table><tr><td colspan='2'>[[6n4b]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N4B FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6n4b" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6n4b" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transducin 3D structures\|Transducin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 18:38, 11 December 2019

OCA — Wed, 11 Dec 2019 18:38:19 GMT

←Older revision		Revision as of 18:38, 11 December 2019
Line 1:		Line 1:

	==Cannabinoid Receptor 1-G Protein Complex==		==Cannabinoid Receptor 1-G Protein Complex==
-	<StructureSection load='6n4b' size='340' side='right' caption='[[6n4b]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='6n4b' size='340' side='right'caption='[[6n4b]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n4b]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N4B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n4b]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N4B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KCA:methyl+N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate'>KCA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KCA:methyl+N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate'>KCA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNAI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CNR1, CNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n4b OCA], [http://pdbe.org/6n4b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n4b RCSB], [http://www.ebi.ac.uk/pdbsum/6n4b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n4b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n4b OCA], [http://pdbe.org/6n4b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n4b RCSB], [http://www.ebi.ac.uk/pdbsum/6n4b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n4b ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Hu, H]]		[[Category: Hu, H]]
	[[Category: Kobilka, B K]]		[[Category: Kobilka, B K]]

OCA at 08:44, 30 January 2019

OCA — Wed, 30 Jan 2019 08:44:54 GMT

←Older revision		Revision as of 08:44, 30 January 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6n4b is ~~ON HOLD~~	+	==Cannabinoid Receptor 1-G Protein Complex==
		+	<StructureSection load='6n4b' size='340' side='right' caption='[[6n4b]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6n4b]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N4B FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KCA:methyl+N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate'>KCA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n4b OCA], [http://pdbe.org/6n4b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n4b RCSB], [http://www.ebi.ac.uk/pdbsum/6n4b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n4b ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN]] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref> [[http://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> [[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor 1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl cyclase-inhibiting heterotrimeric G protein Gi. Activation of CB1-Gi signaling pathways holds potential for treating a number of neurological disorders and is thus crucial to understand the mechanism of Gi activation by CB1. Here, we present the structure of the CB1-Gi signaling complex bound to the highly potent agonist MDMB-Fubinaca (FUB), a recently emerged illicit synthetic cannabinoid infused in street drugs that have been associated with numerous overdoses and fatalities. The structure illustrates how FUB stabilizes the receptor in an active state to facilitate nucleotide exchange in Gi. The results compose the structural framework to explain CB1 activation by different classes of ligands and provide insights into the G protein coupling and selectivity mechanisms adopted by the receptor.

-	~~Authors~~:	+	Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.,Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G Cell. 2019 Jan 24;176(3):448-458.e12. doi: 10.1016/j.cell.2018.11.040. Epub 2019 , Jan 10. PMID:30639101<ref>PMID:30639101</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6n4b" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hu, H]]
		+	[[Category: Kobilka, B K]]
		+	[[Category: Kumar, K Krishna]]
		+	[[Category: Shalev-Benami, M]]
		+	[[Category: Skiniotis, G]]
		+	[[Category: Weis, W I]]
		+	[[Category: Cannabinoid receptor]]
		+	[[Category: Fubinaca]]
		+	[[Category: Gi]]
		+	[[Category: Gpcr]]
		+	[[Category: Signaling protein]]
		+	[[Category: Synthetic cannabinoid]]

OCA: Protected "6n4b" [edit=sysop:move=sysop]

OCA — Sun, 02 Dec 2018 19:15:03 GMT

Protected "6n4b" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:15, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n4b is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Sun, 02 Dec 2018 19:15:01 GMT

New page: '''Unreleased structure''' The entry 6n4b is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6n4b is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]