OCA at 08:44, 30 January 2019

OCA — Wed, 30 Jan 2019 08:44:33 GMT

←Older revision		Revision as of 08:44, 30 January 2019
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-	'''Unreleased structure'''

-	The ~~entry~~ 6n4d is ~~ON HOLD~~	+	==The crystal structure of neuramindase from A/canine/IL/11613/2015 (H3N2) influenza virus.==
		+	<StructureSection load='6n4d' size='340' side='right' caption='[[6n4d]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6n4d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N4D FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n4d OCA], [http://pdbe.org/6n4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n4d RCSB], [http://www.ebi.ac.uk/pdbsum/6n4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n4d ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A0H3YBU9_9INFA A0A0H3YBU9_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071][SAAS:SAAS00844152]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Background: A single subtype of canine influenza virus (CIV), A(H3N8), was circulating in the United States until a new subtype, A(H3N2), was detected in Illinois in spring 2015. Since then, this CIV has caused thousands of infections in dogs in multiple states. Methods: In this study, genetic and antigenic properties of the new CIV were evaluated. In addition, structural and glycan array binding features of the recombinant hemagglutinin were determined. Replication kinetics in human airway cells and pathogenesis and transmissibility in animal models were also assessed. Results: A(H3N2) CIVs maintained molecular and antigenic features related to low pathogenicity avian influenza A(H3N2) viruses and were distinct from A(H3N8) CIVs. The structural and glycan array binding profile confirmed these findings and revealed avian-like receptor-binding specificity. While replication kinetics in human airway epithelial cells was on par with that of seasonal influenza viruses, mild-to-moderate disease was observed in infected mice and ferrets, and the virus was inefficiently transmitted among cohoused ferrets. Conclusions: Further adaptation is needed for A(H3N2) CIVs to present a likely threat to humans. However, the potential for coinfection of dogs and possible reassortment of human and other animal influenza A viruses presents an ongoing risk to public health.

-	~~Authors:~~ Yang, H., Stevens, J.	+	Assessment of Molecular, Antigenic, and Pathological Features of Canine Influenza A(H3N2) Viruses That Emerged in the United States.,Pulit-Penaloza JA, Simpson N, Yang H, Creager HM, Jones J, Carney P, Belser JA, Yang G, Chang J, Zeng H, Thor S, Jang Y, Killian ML, Jenkins-Moore M, Janas-Martindale A, Dubovi E, Wentworth DE, Stevens J, Tumpey TM, Davis CT, Maines TR J Infect Dis. 2017 Sep 15;216(suppl_4):S499-S507. doi: 10.1093/infdis/jiw620. PMID:28934454<ref>PMID:28934454</ref>

-	~~Description: The crystal structure~~ of ~~neuramindase from A~~/~~canine~~/IL/~~11613/2015 (H3N2) influenza virus.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Yang, H]]~~	+	<div class="pdbe-citations 6n4d" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Stevens, J]]		[[Category: Stevens, J]]
		+	[[Category: Yang, H]]
		+	[[Category: Canine influenza virus]]
		+	[[Category: Neuraminidase]]
		+	[[Category: Viral protein]]

OCA: Protected "6n4d" [edit=sysop:move=sysop]

OCA — Sun, 02 Dec 2018 19:15:23 GMT

Protected "6n4d" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:15, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n4d is ON HOLD Authors: Yang, H., Stevens, J. Description: The crystal structure of neuramindase from A/canine/IL/11613/2015 (H3N2) influenza viru...

OCA — Sun, 02 Dec 2018 19:15:22 GMT

New page: '''Unreleased structure''' The entry 6n4d is ON HOLD Authors: Yang, H., Stevens, J. Description: The crystal structure of neuramindase from A/canine/IL/11613/2015 (H3N2) influenza viru...

New page

'''Unreleased structure'''

The entry 6n4d is ON HOLD

Authors: Yang, H., Stevens, J.

Description: The crystal structure of neuramindase from A/canine/IL/11613/2015 (H3N2) influenza virus.
[[Category: Unreleased Structures]]
[[Category: Yang, H]]
[[Category: Stevens, J]]

6n4d - Revision history

OCA at 08:44, 30 January 2019

OCA: Protected "6n4d" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6n4d is ON HOLD Authors: Yang, H., Stevens, J. Description: The crystal structure of neuramindase from A/canine/IL/11613/2015 (H3N2) influenza viru...