OCA at 08:44, 30 January 2019

OCA — Wed, 30 Jan 2019 08:44:48 GMT

←Older revision		Revision as of 08:44, 30 January 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6n4f is ~~ON HOLD~~	+	==The crystal structure of hemagglutinin from A/canine/IL/11613/2015 (H3N2) influenza virus.==
		+	<StructureSection load='6n4f' size='340' side='right' caption='[[6n4f]], [[Resolution\|resolution]] 3.01Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6n4f]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N4F FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n4f OCA], [http://pdbe.org/6n4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n4f RCSB], [http://www.ebi.ac.uk/pdbsum/6n4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n4f ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A218KIQ1_9INFA A0A218KIQ1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072][SAAS:SAAS01039073] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324] [[http://www.uniprot.org/uniprot/A0A2U5FPI7_9INFA A0A2U5FPI7_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072][SAAS:SAAS01039073] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Background: A single subtype of canine influenza virus (CIV), A(H3N8), was circulating in the United States until a new subtype, A(H3N2), was detected in Illinois in spring 2015. Since then, this CIV has caused thousands of infections in dogs in multiple states. Methods: In this study, genetic and antigenic properties of the new CIV were evaluated. In addition, structural and glycan array binding features of the recombinant hemagglutinin were determined. Replication kinetics in human airway cells and pathogenesis and transmissibility in animal models were also assessed. Results: A(H3N2) CIVs maintained molecular and antigenic features related to low pathogenicity avian influenza A(H3N2) viruses and were distinct from A(H3N8) CIVs. The structural and glycan array binding profile confirmed these findings and revealed avian-like receptor-binding specificity. While replication kinetics in human airway epithelial cells was on par with that of seasonal influenza viruses, mild-to-moderate disease was observed in infected mice and ferrets, and the virus was inefficiently transmitted among cohoused ferrets. Conclusions: Further adaptation is needed for A(H3N2) CIVs to present a likely threat to humans. However, the potential for coinfection of dogs and possible reassortment of human and other animal influenza A viruses presents an ongoing risk to public health.

-	~~Authors:~~ Yang, H., ~~Stevesn~~, J.	+	Assessment of Molecular, Antigenic, and Pathological Features of Canine Influenza A(H3N2) Viruses That Emerged in the United States.,Pulit-Penaloza JA, Simpson N, Yang H, Creager HM, Jones J, Carney P, Belser JA, Yang G, Chang J, Zeng H, Thor S, Jang Y, Killian ML, Jenkins-Moore M, Janas-Martindale A, Dubovi E, Wentworth DE, Stevens J, Tumpey TM, Davis CT, Maines TR J Infect Dis. 2017 Sep 15;216(suppl_4):S499-S507. doi: 10.1093/infdis/jiw620. PMID:28934454<ref>PMID:28934454</ref>

-	~~Description: The crystal structure~~ of ~~hemagglutinin from A~~/~~canine~~/IL/~~11613/2015 (H3N2) influenza virus.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 6n4f" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Stevesn, J]]		[[Category: Stevesn, J]]
	[[Category: Yang, H]]		[[Category: Yang, H]]
		+	[[Category: Canine influenza virus]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Viral protein]]

OCA: Protected "6n4f" [edit=sysop:move=sysop]

OCA — Sun, 02 Dec 2018 19:15:31 GMT

Protected "6n4f" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:15, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n4f is ON HOLD Authors: Yang, H., Stevesn, J. Description: The crystal structure of hemagglutinin from A/canine/IL/11613/2015 (H3N2) influenza vir...

OCA — Sun, 02 Dec 2018 19:15:30 GMT

New page: '''Unreleased structure''' The entry 6n4f is ON HOLD Authors: Yang, H., Stevesn, J. Description: The crystal structure of hemagglutinin from A/canine/IL/11613/2015 (H3N2) influenza vir...

New page

'''Unreleased structure'''

The entry 6n4f is ON HOLD

Authors: Yang, H., Stevesn, J.

Description: The crystal structure of hemagglutinin from A/canine/IL/11613/2015 (H3N2) influenza virus.
[[Category: Unreleased Structures]]
[[Category: Stevesn, J]]
[[Category: Yang, H]]

6n4f - Revision history

OCA at 08:44, 30 January 2019

OCA: Protected "6n4f" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6n4f is ON HOLD Authors: Yang, H., Stevesn, J. Description: The crystal structure of hemagglutinin from A/canine/IL/11613/2015 (H3N2) influenza vir...