6n67 - Revision history

OCA at 06:28, 10 July 2019

OCA — Wed, 10 Jul 2019 06:28:22 GMT

←Older revision		Revision as of 06:28, 10 July 2019
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	<StructureSection load='6n67' size='340' side='right'caption='[[6n67]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6n67' size='340' side='right'caption='[[6n67]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n67]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N67 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N67 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0034810 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_ligase_(ATP) RNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.3 6.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_ligase_(ATP) RNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.3 6.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n67 OCA], [http://pdbe.org/6n67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n67 RCSB], [http://www.ebi.ac.uk/pdbsum/6n67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n67 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n67 OCA], [http://pdbe.org/6n67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n67 RCSB], [http://www.ebi.ac.uk/pdbsum/6n67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n67 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR). The UPR regulates the protein folding capacity of the endoplasmic reticulum (ER). ER stress activates Ire1, an ER-resident kinase/RNase, which excises an intron from HAC1 mRNA followed by exon-exon ligation by Trl1. The spliced product encodes for a potent transcription factor that drives the UPR. Here we report the crystal structure of Trl1 RNA ligase domain from Chaetomium thermophilum at 1.9 A resolution. Structure-based mutational analyses uncovered kinetic competition between RNA ligation and degradation during HAC1 mRNA splicing. Incompletely processed HAC1 mRNA is degraded by Xrn1 and the Ski/exosome complex. We establish cleaved HAC1 mRNA as endogenous substrate for ribosome-associated quality control. We conclude that mRNA decay and surveillance mechanisms collaborate in achieving fidelity of non-conventional mRNA splicing during the UPR.
		+
		+	tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay.,Peschek J, Walter P Elife. 2019 Jun 25;8. pii: 44199. doi: 10.7554/eLife.44199. PMID:31237564<ref>PMID:31237564</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6n67" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chatd]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Peschek, J]]		[[Category: Peschek, J]]

OCA at 05:54, 3 July 2019

OCA — Wed, 03 Jul 2019 05:54:24 GMT

←Older revision		Revision as of 05:54, 3 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6n67 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the ligase domain of fungal tRNA ligase Trl1==
-		+	<StructureSection load='6n67' size='340' side='right'caption='[[6n67]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6n67]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N67 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_ligase_(ATP) RNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.3 6.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n67 OCA], [http://pdbe.org/6n67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n67 RCSB], [http://www.ebi.ac.uk/pdbsum/6n67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n67 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Peschek, J]]
		+	[[Category: Walter, P]]
		+	[[Category: Atp-binding]]
		+	[[Category: Inhibitor]]
		+	[[Category: Ligase]]
		+	[[Category: Rna ligase]]
		+	[[Category: Trna splicing]]

OCA at 06:32, 19 December 2018

OCA — Wed, 19 Dec 2018 06:32:15 GMT

←Older revision		Revision as of 06:32, 19 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n67 is ON HOLD	+	The entry 6n67 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6n67" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2018 05:16:20 GMT

Protected "6n67" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:16, 5 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n67 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Dec 2018 05:16:19 GMT

New page: '''Unreleased structure''' The entry 6n67 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6n67 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]