6n6p - Revision history

OCA at 06:47, 11 October 2023

OCA — Wed, 11 Oct 2023 06:47:03 GMT

←Older revision		Revision as of 06:47, 11 October 2023
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	<StructureSection load='6n6p' size='340' side='right'caption='[[6n6p]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='6n6p' size='340' side='right'caption='[[6n6p]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n6p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pasteurianus"_(winogradsky_1895)_lehmann_and_neumann_1907 "bacillus pasteurianus" (winogradsky 1895) lehmann and neumann 1907~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N6P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N6P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=402:DICARBONYL[BIS(CYANIDE-KAPPAC)]-MU-(IMINODIMETHANETHIOLATATO-1KAPPAS 2KAPPAS)-MU-(OXOMETHYLIDENE)DIIRON(2+)'>402</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6n59\|6n59]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=402:DICARBONYL[BIS(CYANIDE-KAPPAC)]-MU-(IMINODIMETHANETHIOLATATO-1KAPPAS 2KAPPAS)-MU-(OXOMETHYLIDENE)DIIRON(2+)'>402</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferredoxin_hydrogenase Ferredoxin hydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.12.7.2 1.12.7.2] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6p OCA], [https://pdbe.org/6n6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n6p RCSB], [https://www.ebi.ac.uk/pdbsum/6n6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6p ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6p OCA], [~~http~~://pdbe.org/6n6p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6n6p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6n6p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6p ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PHF1_CLOPA PHF1_CLOPA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ferredoxin hydrogenase]]
-	[[Category: Large Structures]]
-	[[Category: Keable, S M]]
-	[[Category: Peters, J W]]
-	[[Category: Zadvornyy, O A]]
-	[[Category: Catalysis]]
	[[Category: Clostridium pasteurianum]]		[[Category: Clostridium pasteurianum]]
-	[[Category: ~~Electron-transfer~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Iron sulfur cluster~~]]	+	[[Category: Keable SM]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Peters JW]]
		+	[[Category: Zadvornyy OA]]

OCA at 16:39, 22 January 2020

OCA — Wed, 22 Jan 2020 16:39:06 GMT

←Older revision		Revision as of 16:39, 22 January 2020
Line 3:		Line 3:
	<StructureSection load='6n6p' size='340' side='right'caption='[[6n6p]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='6n6p' size='340' side='right'caption='[[6n6p]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n6p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N6P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pasteurianus"_(winogradsky_1895)_lehmann_and_neumann_1907 "bacillus pasteurianus" (winogradsky 1895) lehmann and neumann 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N6P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=402:DICARBONYL[BIS(CYANIDE-KAPPAC)]-MU-(IMINODIMETHANETHIOLATATO-1KAPPAS 2KAPPAS)-MU-(OXOMETHYLIDENE)DIIRON(2+)'>402</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=402:DICARBONYL[BIS(CYANIDE-KAPPAC)]-MU-(IMINODIMETHANETHIOLATATO-1KAPPAS 2KAPPAS)-MU-(OXOMETHYLIDENE)DIIRON(2+)'>402</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6n59\|6n59]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6n59\|6n59]]</td></tr>

OCA at 09:06, 25 December 2019

OCA — Wed, 25 Dec 2019 09:06:43 GMT

←Older revision		Revision as of 09:06, 25 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6n6p is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of [FeFe]-hydrogenase in the presence of 7 mM Sodium dithionite==
		+	<StructureSection load='6n6p' size='340' side='right'caption='[[6n6p]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6n6p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N6P FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=402:DICARBONYL[BIS(CYANIDE-KAPPAC)]-MU-(IMINODIMETHANETHIOLATATO-1KAPPAS 2KAPPAS)-MU-(OXOMETHYLIDENE)DIIRON(2+)'>402</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6n59\|6n59]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferredoxin_hydrogenase Ferredoxin hydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.12.7.2 1.12.7.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6p OCA], [http://pdbe.org/6n6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n6p RCSB], [http://www.ebi.ac.uk/pdbsum/6n6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6p ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hydrogenases display a wide range of catalytic rates and biases in reversible hydrogen gas oxidation catalysis. The interac-tions of the iron-sulfur containing catalytic site with the local protein environment are thought to contribute to differences in catalytic reactivity, but this has not been demonstrated. The microbe Clostridium pasteurianum produces three [FeFe]-hydrogenases that differ in "catalytic bias" by exerting a disproportionate rate acceleration in one direction or the other that spans a remarkable six orders of magnitude. The combination of high-resolution structural work, biochemical analyses, and computational modeling indicate that protein secondary interactions directly influence the relative stabiliza-tion/destabilization of different oxidation states of the active site metal cluster. This selective stabilization or destabilization of oxidation states can preferentially promote hydrogen oxidation or proton reduction and represents a simple yet elegant model by which a protein catalytic site can confer catalytic bias.

-	~~Authors~~:	+	Tuning catalytic bias of hydrogen gas producing hydrogenases.,Artz JH, Zadvornyy OA, Mulder DW, Keable SM, Cohen AE, Ratzloff MW, Williams SG, Ginovska B, Kumar N, Song J, McPhillips SE, Davidson C, Lyubimov AY, Pence N, Schut GJ, Jones AK, Soltis SM, Adams M, Raugei S, King PW, Peters JW J Am Chem Soc. 2019 Dec 9. doi: 10.1021/jacs.9b08756. PMID:31816235<ref>PMID:31816235</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6n6p" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ferredoxin hydrogenase]]
		+	[[Category: Large Structures]]
		+	[[Category: Keable, S M]]
		+	[[Category: Peters, J W]]
		+	[[Category: Zadvornyy, O A]]
		+	[[Category: Catalysis]]
		+	[[Category: Clostridium pasteurianum]]
		+	[[Category: Electron-transfer]]
		+	[[Category: Iron sulfur cluster]]
		+	[[Category: Oxidoreductase]]

OCA at 06:26, 30 January 2019

OCA — Wed, 30 Jan 2019 06:26:15 GMT

←Older revision		Revision as of 06:26, 30 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n6p is ON HOLD	+	The entry 6n6p is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6n6p" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2018 05:17:27 GMT

Protected "6n6p" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 5 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n6p is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Dec 2018 05:17:26 GMT

New page: '''Unreleased structure''' The entry 6n6p is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6n6p is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]