6n6q - Revision history

OCA at 14:46, 13 March 2024

OCA — Wed, 13 Mar 2024 14:46:48 GMT

←Older revision		Revision as of 14:46, 13 March 2024
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	<StructureSection load='6n6q' size='340' side='right'caption='[[6n6q]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6n6q' size='340' side='right'caption='[[6n6q]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n6q]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycobacterium_abcessus_subsp._bolletii_mycobacteriophage_adler~~ Mycobacterium ~~abcessus subsp. bolletii mycobacteriophage adler~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N6Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n6q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_phage_Adler Mycobacterium phage Adler]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N6Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CAC:CACODYLATE+ION'>CAC</scene~~>, ~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MaF1660_ph0012 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=1327959 Mycobacterium abcessus subsp. bolletii mycobacteriophage Adler])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6q OCA], [~~http~~://pdbe.org/6n6q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6n6q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6n6q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6q OCA], [https://pdbe.org/6n6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n6q RCSB], [https://www.ebi.ac.uk/pdbsum/6n6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6q ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/V5UQK0_9CAUD V5UQK0_9CAUD]
-	Genes encoding cytochrome P450 (CYP; P450) enzymes occur widely in the Archaea, Bacteria, and Eukarya, where they play important roles in metabolism of endogenous regulatory molecules and exogenous chemicals. We now report that genes for multiple and unique P450s occur commonly in giant viruses in the Mimiviridae, Pandoraviridae, and other families in the proposed order Megavirales. P450 genes were also identified in a herpesvirus (Ranid herpesvirus 3) and a phage (Mycobacterium phage Adler). The Adler phage P450 was classified as CYP102L1, and the crystal structure of the open form was solved at 2.5 A. Genes encoding known redox partners for P450s (cytochrome P450 reductase, ferredoxin and ferredoxin reductase, and flavodoxin and flavodoxin reductase) were not found in any viral genome so far described, implying that host redox partners may drive viral P450 activities. Giant virus P450 proteins share no more than 25% identity with the P450 gene products we identified in Acanthamoeba castellanii, an amoeba host for many giant viruses. Thus, the origin of the unique P450 genes in giant viruses remains unknown. If giant virus P450 genes were acquired from a host, we suggest it could have been from an as yet unknown and possibly ancient host. These studies expand the horizon in the evolution and diversity of the enormously important P450 superfamily. ~~Determining the origin and function of P450s in giant viruses may help to discern the origin of the giant viruses themselves~~.	+

-	On the occurrence of cytochrome P450 in viruses.,Lamb DC, Follmer AH, Goldstone JV, Nelson DR, Warrilow AG, Price CL, True MY, Kelly SL, Poulos TL, Stegeman JJ Proc Natl Acad Sci U S A. 2019 Jun 5. pii: 1901080116. doi:, 10.1073/pnas.1901080116. PMID:31167942<ref>PMID:31167942</ref>	+	==See Also==
-		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 6n6q" style~~=~~"background-color:#fffaf0;"></div>~~	+
-	~~== References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Mycobacterium ~~abcessus subsp. bolletii mycobacteriophage adler~~]]	+	[[Category: Mycobacterium phage Adler]]
-	[[Category: Follmer~~, A H~~]]	+	[[Category: Follmer AH]]
-	[[Category: Poulos~~, T L]]~~	+	[[Category: Poulos TL]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 06:53, 3 July 2019

OCA — Wed, 03 Jul 2019 06:53:13 GMT

←Older revision		Revision as of 06:53, 3 July 2019
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	<StructureSection load='6n6q' size='340' side='right'caption='[[6n6q]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6n6q' size='340' side='right'caption='[[6n6q]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n6q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N6Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n6q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_abcessus_subsp._bolletii_mycobacteriophage_adler Mycobacterium abcessus subsp. bolletii mycobacteriophage adler]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N6Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MaF1660_ph0012 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1327959 Mycobacterium abcessus subsp. bolletii mycobacteriophage Adler])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6q OCA], [http://pdbe.org/6n6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n6q RCSB], [http://www.ebi.ac.uk/pdbsum/6n6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6q OCA], [http://pdbe.org/6n6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n6q RCSB], [http://www.ebi.ac.uk/pdbsum/6n6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6q ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mycobacterium abcessus subsp. bolletii mycobacteriophage adler]]
	[[Category: Follmer, A H]]		[[Category: Follmer, A H]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 06:32, 19 June 2019

OCA — Wed, 19 Jun 2019 06:32:29 GMT

←Older revision		Revision as of 06:32, 19 June 2019
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6q OCA], [http://pdbe.org/6n6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n6q RCSB], [http://www.ebi.ac.uk/pdbsum/6n6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6q OCA], [http://pdbe.org/6n6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n6q RCSB], [http://www.ebi.ac.uk/pdbsum/6n6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6q ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Genes encoding cytochrome P450 (CYP; P450) enzymes occur widely in the Archaea, Bacteria, and Eukarya, where they play important roles in metabolism of endogenous regulatory molecules and exogenous chemicals. We now report that genes for multiple and unique P450s occur commonly in giant viruses in the Mimiviridae, Pandoraviridae, and other families in the proposed order Megavirales. P450 genes were also identified in a herpesvirus (Ranid herpesvirus 3) and a phage (Mycobacterium phage Adler). The Adler phage P450 was classified as CYP102L1, and the crystal structure of the open form was solved at 2.5 A. Genes encoding known redox partners for P450s (cytochrome P450 reductase, ferredoxin and ferredoxin reductase, and flavodoxin and flavodoxin reductase) were not found in any viral genome so far described, implying that host redox partners may drive viral P450 activities. Giant virus P450 proteins share no more than 25% identity with the P450 gene products we identified in Acanthamoeba castellanii, an amoeba host for many giant viruses. Thus, the origin of the unique P450 genes in giant viruses remains unknown. If giant virus P450 genes were acquired from a host, we suggest it could have been from an as yet unknown and possibly ancient host. These studies expand the horizon in the evolution and diversity of the enormously important P450 superfamily. Determining the origin and function of P450s in giant viruses may help to discern the origin of the giant viruses themselves.
		+
		+	On the occurrence of cytochrome P450 in viruses.,Lamb DC, Follmer AH, Goldstone JV, Nelson DR, Warrilow AG, Price CL, True MY, Kelly SL, Poulos TL, Stegeman JJ Proc Natl Acad Sci U S A. 2019 Jun 5. pii: 1901080116. doi:, 10.1073/pnas.1901080116. PMID:31167942<ref>PMID:31167942</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6n6q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 22:49, 5 June 2019

OCA — Wed, 05 Jun 2019 22:49:11 GMT

←Older revision		Revision as of 22:49, 5 June 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6n6q is ~~ON HOLD until Nov 25 2020~~	+	==Crystal structure of a Cytochrome P450 (CYP102L1)==
-		+	<StructureSection load='6n6q' size='340' side='right'caption='[[6n6q]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~: ~~Follmer~~, A.H., ~~Poulos~~, T.L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6n6q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N6Q FirstGlance]. <br>
-	~~Description: Crystal structure of a Cytochrome P450 (CYP102L1)~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n6q OCA], [http://pdbe.org/6n6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n6q RCSB], [http://www.ebi.ac.uk/pdbsum/6n6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n6q ProSAT]</span></td></tr>
-	[[Category: Poulos, T.L]]	+	</table>
-	[[Category: ~~Follmer, A.H~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Follmer, A H]]
		+	[[Category: Poulos, T L]]
		+	[[Category: Oxidoreductase]]

OCA at 04:55, 27 March 2019

OCA — Wed, 27 Mar 2019 04:55:09 GMT

←Older revision		Revision as of 04:55, 27 March 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n6q is ON HOLD until ~~May 26~~ 2020	+	The entry 6n6q is ON HOLD until Nov 25 2020

	Authors: Follmer, A.H., Poulos, T.L.		Authors: Follmer, A.H., Poulos, T.L.

OCA at 07:31, 13 February 2019

OCA — Wed, 13 Feb 2019 07:31:57 GMT

←Older revision		Revision as of 07:31, 13 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n6q is ON HOLD	+	The entry 6n6q is ON HOLD until May 26 2020

	Authors: Follmer, A.H., Poulos, T.L.		Authors: Follmer, A.H., Poulos, T.L.

OCA: Protected "6n6q" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2018 05:17:30 GMT

Protected "6n6q" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 5 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n6q is ON HOLD Authors: Follmer, A.H., Poulos, T.L. Description: Crystal structure of a Cytochrome P450 (CYP102L1) [[Category: Unreleased Structur...

OCA — Wed, 05 Dec 2018 05:17:29 GMT

New page: '''Unreleased structure''' The entry 6n6q is ON HOLD Authors: Follmer, A.H., Poulos, T.L. Description: Crystal structure of a Cytochrome P450 (CYP102L1) [[Category: Unreleased Structur...

New page

'''Unreleased structure'''

The entry 6n6q is ON HOLD

Authors: Follmer, A.H., Poulos, T.L.

Description: Crystal structure of a Cytochrome P450 (CYP102L1)
[[Category: Unreleased Structures]]
[[Category: Poulos, T.L]]
[[Category: Follmer, A.H]]