6n7j - Revision history

OCA at 06:47, 11 October 2023

OCA — Wed, 11 Oct 2023 06:47:27 GMT

←Older revision		Revision as of 06:47, 11 October 2023
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	<StructureSection load='6n7j' size='340' side='right'caption='[[6n7j]], [[Resolution\|resolution]] 3.68Å' scene=''>		<StructureSection load='6n7j' size='340' side='right'caption='[[6n7j]], [[Resolution\|resolution]] 3.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n7j]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N7J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n7j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bundibugyo_ebolavirus Bundibugyo ebolavirus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N7J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n7j OCA], [~~http~~://pdbe.org/6n7j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6n7j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6n7j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6n7j ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.684Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n7j OCA], [https://pdbe.org/6n7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n7j RCSB], [https://www.ebi.ac.uk/pdbsum/6n7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n7j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B8XCN0_9MONO B8XCN0_9MONO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6n7j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6n7j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Bundibugyo ebolavirus]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: King~~, L B~~]]	+	[[Category: King LB]]
-	[[Category: Saphire~~, E O~~]]	+	[[Category: Saphire EO]]
-	[[Category: West~~, B R]]~~	+	[[Category: West BR]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Antiviral protein]]~~	+
-	~~[[Category: Viral protein-immune system complex~~]]	+

OCA at 11:12, 2 October 2019

OCA — Wed, 02 Oct 2019 11:12:00 GMT

←Older revision		Revision as of 11:12, 2 October 2019
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	<StructureSection load='6n7j' size='340' side='right'caption='[[6n7j]], [[Resolution\|resolution]] 3.68Å' scene=''>		<StructureSection load='6n7j' size='340' side='right'caption='[[6n7j]], [[Resolution\|resolution]] 3.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n7j]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n7j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N7J FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n7j OCA], [http://pdbe.org/6n7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n7j RCSB], [http://www.ebi.ac.uk/pdbsum/6n7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n7j ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n7j OCA], [http://pdbe.org/6n7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n7j RCSB], [http://www.ebi.ac.uk/pdbsum/6n7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n7j ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Three Ebolavirus genus viruses cause lethal disease and lack targeted therapeutics: Ebola virus, Sudan virus and Bundibugyo virus. Monoclonal antibody (mAb) cocktails against the surface glycoprotein (GP) present a potential therapeutic strategy. Here we report two crystal structures of the antibody BDBV223, alone and complexed with its GP2 stalk epitope, an interesting site for therapeutic/vaccine design due to its high sequence conservation among ebolaviruses. BDBV223, identified in a human survivor of Bundibugyo virus disease, neutralizes both Bundibugyo virus and Ebola virus, but not Sudan virus. Importantly, the structure suggests that BDBV223 binding interferes with both the trimeric bundle assembly of GP and the viral membrane by stabilizing a conformation in which the monomers are separated by GP lifting or bending. Targeted mutagenesis of BDBV223 to enhance SUDV GP recognition indicates that additional determinants of antibody binding likely lie outside the visualized interactions, and perhaps involve quaternary assembly or membrane-interacting regions.
		+
		+	Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk.,King LB, West BR, Moyer CL, Gilchuk P, Flyak A, Ilinykh PA, Bombardi R, Hui S, Huang K, Bukreyev A, Crowe JE Jr, Saphire EO Nat Commun. 2019 Apr 17;10(1):1788. doi: 10.1038/s41467-019-09732-7. PMID:30996276<ref>PMID:30996276</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6n7j" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: King, L B]]		[[Category: King, L B]]

OCA at 08:03, 20 March 2019

OCA — Wed, 20 Mar 2019 08:03:04 GMT

←Older revision		Revision as of 08:03, 20 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6n7j is ~~ON HOLD until Paper Publication~~	+	==BDBV223 Fab bound to synthetic peptide of Bundibugyo virus Glycoprotein Stalk==
-		+	<StructureSection load='6n7j' size='340' side='right'caption='[[6n7j]], [[Resolution\|resolution]] 3.68Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6n7j]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N7J FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n7j OCA], [http://pdbe.org/6n7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n7j RCSB], [http://www.ebi.ac.uk/pdbsum/6n7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n7j ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: King, L B]]
		+	[[Category: Saphire, E O]]
		+	[[Category: West, B R]]
		+	[[Category: Antibody]]
		+	[[Category: Antiviral protein]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 05:20, 12 December 2018

OCA — Wed, 12 Dec 2018 05:20:34 GMT

←Older revision		Revision as of 05:20, 12 December 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n7j is ON HOLD	+	The entry 6n7j is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6n7j" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2018 05:19:18 GMT

Protected "6n7j" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:19, 5 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n7j is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Dec 2018 05:19:17 GMT

New page: '''Unreleased structure''' The entry 6n7j is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6n7j is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]