6n84 - Revision history

OCA at 06:47, 11 October 2023

OCA — Wed, 11 Oct 2023 06:47:37 GMT

←Older revision		Revision as of 06:47, 11 October 2023
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	<StructureSection load='6n84' size='340' side='right'caption='[[6n84]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='6n84' size='340' side='right'caption='[[6n84]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n84]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N84 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N84 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n84]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N84 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MAL:MALTOSE'>MAL</scene~~>, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~GNAT2, GNATC ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id~~=~~9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n84 OCA], [~~http~~://pdbe.org/6n84 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6n84 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6n84 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6n84 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n84 OCA], [https://pdbe.org/6n84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n84 RCSB], [https://www.ebi.ac.uk/pdbsum/6n84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n84 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAT2_HUMAN GNAT2_HUMAN] Progressive cone dystrophy;Achromatopsia. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~MALE_ECO57 MALE_ECO57]~~] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (~~By similarity~~).	+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/GNAT2_HUMAN GNAT2_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Escherichia coli O157:H7]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Artemyev~~, N O~~]]	+	[[Category: Artemyev NO]]
-	[[Category: Gakhar, L]]	+	[[Category: Gakhar L]]
-	[[Category: Srivastava, D]]	+	[[Category: Srivastava D]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: G alpha]]~~	+
-	~~[[Category: Mbp~~]]	+

OCA at 08:39, 24 July 2019

OCA — Wed, 24 Jul 2019 08:39:07 GMT

←Older revision		Revision as of 08:39, 24 July 2019
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	<StructureSection load='6n84' size='340' side='right'caption='[[6n84]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='6n84' size='340' side='right'caption='[[6n84]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n84]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N84 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N84 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n84]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N84 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N84 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNAT2, GNATC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n84 OCA], [http://pdbe.org/6n84 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n84 RCSB], [http://www.ebi.ac.uk/pdbsum/6n84 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n84 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n84 OCA], [http://pdbe.org/6n84 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n84 RCSB], [http://www.ebi.ac.uk/pdbsum/6n84 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n84 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).		[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Resistance to inhibitors of cholinesterase 8A (Ric8A) is an essential regulator of G protein alpha-subunits (Galpha), acting as a guanine nucleotide exchange factor and a chaperone. We report two crystal structures of Ric8A, one in the apo form and the other in complex with a tagged C-terminal fragment of Galpha. These structures reveal two principal domains of Ric8A: an armadillo-fold core and a flexible C-terminal tail. Additionally, they show that the Galpha C-terminus binds to a highly-conserved patch on the concave surface of the Ric8A armadillo-domain, with selectivity determinants residing in the Galpha sequence. Biochemical analysis shows that the Ric8A C-terminal tail is critical for its stability and function. A model of the Ric8A/Galpha complex derived from crosslinking mass spectrometry and molecular dynamics simulations suggests that the Ric8A C-terminal tail helps organize the GTP-binding site of Galpha. This study lays the groundwork for understanding Ric8A function at the molecular level.
		+
		+	Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor.,Srivastava D, Gakhar L, Artemyev NO Nat Commun. 2019 Jul 12;10(1):3084. doi: 10.1038/s41467-019-11088-x. PMID:31300652<ref>PMID:31300652</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6n84" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Artemyev, N O]]		[[Category: Artemyev, N O]]

OCA at 05:46, 10 July 2019

OCA — Wed, 10 Jul 2019 05:46:41 GMT

←Older revision		Revision as of 05:46, 10 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6n84 is ~~ON HOLD until Paper Publication~~	+	==MBP-fusion protein of transducin-alpha residues 327-350==
-		+	<StructureSection load='6n84' size='340' side='right'caption='[[6n84]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~Authors~~: ~~Srivastava~~, D., ~~Gakhar~~, L., ~~Artemyev~~, N.O.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6n84]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N84 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N84 FirstGlance]. <br>
-	~~Description~~: ~~MBP~~-~~fusion protein~~ of ~~transducin-alpha residues 327-350~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n84 OCA], [http://pdbe.org/6n84 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n84 RCSB], [http://www.ebi.ac.uk/pdbsum/6n84 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n84 ProSAT]</span></td></tr>
-	[[Category: Artemyev, N.O]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Artemyev, N O]]
	[[Category: Gakhar, L]]		[[Category: Gakhar, L]]
	[[Category: Srivastava, D]]		[[Category: Srivastava, D]]
		+	[[Category: Chaperone]]
		+	[[Category: G alpha]]
		+	[[Category: Mbp]]

OCA at 05:42, 21 May 2019

OCA — Tue, 21 May 2019 05:42:53 GMT

←Older revision		Revision as of 05:42, 21 May 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n84 is ON HOLD	+	The entry 6n84 is ON HOLD until Paper Publication

	Authors: Srivastava, D., Gakhar, L., Artemyev, N.O.		Authors: Srivastava, D., Gakhar, L., Artemyev, N.O.

OCA at 04:50, 24 April 2019

OCA — Wed, 24 Apr 2019 04:50:54 GMT

←Older revision		Revision as of 04:50, 24 April 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n84 is ON HOLD ~~until Paper Publication~~	+	The entry 6n84 is ON HOLD

	Authors: Srivastava, D., Gakhar, L., Artemyev, N.O.		Authors: Srivastava, D., Gakhar, L., Artemyev, N.O.

OCA at 04:53, 2 January 2019

OCA — Wed, 02 Jan 2019 04:53:36 GMT

←Older revision		Revision as of 04:53, 2 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n84 is ON HOLD	+	The entry 6n84 is ON HOLD until Paper Publication

	Authors: Srivastava, D., Gakhar, L., Artemyev, N.O.		Authors: Srivastava, D., Gakhar, L., Artemyev, N.O.

-	Description: ~~structure of~~ MBP-G alpha ~~t peptide~~	+	Description: MBP-fusion protein of transducin-alpha residues 327-350
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Artemyev, N.O]]		[[Category: Artemyev, N.O]]
	[[Category: Gakhar, L]]		[[Category: Gakhar, L]]
	[[Category: Srivastava, D]]		[[Category: Srivastava, D]]

OCA at 05:20, 12 December 2018

OCA — Wed, 12 Dec 2018 05:20:54 GMT

←Older revision		Revision as of 05:20, 12 December 2018
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	Authors: Srivastava, D., Gakhar, L., Artemyev, N.O.		Authors: Srivastava, D., Gakhar, L., Artemyev, N.O.

-	Description: structure of ~~Ric8a in complex with~~ MBP-G alpha t peptide	+	Description: structure of MBP-G alpha t peptide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Artemyev, N.O]]		[[Category: Artemyev, N.O]]
	[[Category: Gakhar, L]]		[[Category: Gakhar, L]]
	[[Category: Srivastava, D]]		[[Category: Srivastava, D]]

OCA: Protected "6n84" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2018 05:20:49 GMT

Protected "6n84" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:20, 5 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n84 is ON HOLD Authors: Srivastava, D., Gakhar, L., Artemyev, N.O. Description: structure of Ric8a in complex with MBP-G alpha t peptide [[Categor...

OCA — Wed, 05 Dec 2018 05:20:48 GMT

New page: '''Unreleased structure''' The entry 6n84 is ON HOLD Authors: Srivastava, D., Gakhar, L., Artemyev, N.O. Description: structure of Ric8a in complex with MBP-G alpha t peptide [[Categor...

New page

'''Unreleased structure'''

The entry 6n84 is ON HOLD

Authors: Srivastava, D., Gakhar, L., Artemyev, N.O.

Description: structure of Ric8a in complex with MBP-G alpha t peptide
[[Category: Unreleased Structures]]
[[Category: Artemyev, N.O]]
[[Category: Gakhar, L]]
[[Category: Srivastava, D]]