6n9b - Revision history

OCA at 06:48, 11 October 2023

OCA — Wed, 11 Oct 2023 06:48:01 GMT

←Older revision		Revision as of 06:48, 11 October 2023
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	<StructureSection load='6n9b' size='340' side='right'caption='[[6n9b]], [[Resolution\|resolution]] 1.22Å' scene=''>		<StructureSection load='6n9b' size='340' side='right'caption='[[6n9b]], [[Resolution\|resolution]] 1.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n9b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N9B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N9B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n9b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N9B FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.219Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cqp\|6cqp]]~~, [[~~6nsj~~\|~~6nsj]], [[6nsi\|6nsi~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ftsY, b3464, JW3429 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n9b OCA], [https://pdbe.org/6n9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n9b RCSB], [https://www.ebi.ac.uk/pdbsum/6n9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n9b ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n9b OCA], [~~http~~://pdbe.org/6n9b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6n9b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6n9b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6n9b ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FTSY_ECOLI FTSY_ECOLI]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:8194520</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15148364</ref> <ref>PMID:17682051</ref>	+	[https://www.uniprot.org/uniprot/FTSY_ECOLI FTSY_ECOLI] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:8194520</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15148364</ref> <ref>PMID:17682051</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ataide~~, S F~~]]	+	[[Category: Ataide SF]]
-	[[Category: Faoro, C]]	+	[[Category: Faoro C]]
-	~~[[Category: Ftsy]]~~	+
-	~~[[Category: Signal recognition particle receptor]]~~	+
-	~~[[Category: Sr]]~~	+
-	~~[[Category: Srp]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 10:20, 18 March 2020

OCA — Wed, 18 Mar 2020 10:20:53 GMT

←Older revision		Revision as of 10:20, 18 March 2020
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	</div>		</div>
	<div class="pdbe-citations 6n9b" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6n9b" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Signal recognition particle receptor\|Signal recognition particle receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:29, 4 December 2019

OCA — Wed, 04 Dec 2019 10:29:42 GMT

←Older revision		Revision as of 10:29, 4 December 2019
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	<StructureSection load='6n9b' size='340' side='right'caption='[[6n9b]], [[Resolution\|resolution]] 1.22Å' scene=''>		<StructureSection load='6n9b' size='340' side='right'caption='[[6n9b]], [[Resolution\|resolution]] 1.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n9b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N9B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n9b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N9B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cqp\|6cqp]], [[6nsj\|6nsj]], [[6nsi\|6nsi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cqp\|6cqp]], [[6nsj\|6nsj]], [[6nsi\|6nsi]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY, b3464, JW3429 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n9b OCA], [http://pdbe.org/6n9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n9b RCSB], [http://www.ebi.ac.uk/pdbsum/6n9b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n9b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n9b OCA], [http://pdbe.org/6n9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n9b RCSB], [http://www.ebi.ac.uk/pdbsum/6n9b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n9b ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ataide, S F]]		[[Category: Ataide, S F]]

OCA at 05:20, 10 October 2019

OCA — Thu, 10 Oct 2019 05:20:25 GMT

←Older revision		Revision as of 05:20, 10 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6n9b is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==FtsY-NG ultra high-resolution==
		+	<StructureSection load='6n9b' size='340' side='right'caption='[[6n9b]], [[Resolution\|resolution]] 1.22Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6n9b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N9B FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cqp\|6cqp]], [[6nsj\|6nsj]], [[6nsi\|6nsi]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n9b OCA], [http://pdbe.org/6n9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n9b RCSB], [http://www.ebi.ac.uk/pdbsum/6n9b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n9b ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FTSY_ECOLI FTSY_ECOLI]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:8194520</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15148364</ref> <ref>PMID:17682051</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial signal recognition particle (SRP) receptor, FtsY, participates with the SRP in co-translation targeting of proteins. Multiple crystal structures of the NG domain of E. coli FtsYNG have been determined at high-resolution (1.22-1.88A), in the nucleotide-free (apo) form as well as bound to GDP and non-hydrolysable GTP analogues. The combination of high-resolution and multiple solved structures of FtsYNG in different states revealed a new sensor-relay system of this unique GTPase receptor. A nucleotide sensing function of the P-loop assists FtsYNG in nucleotide-binding and contributes to modulate nucleotide binding properties in SRP GTPases. A reorganization of the other G-loops and the insertion binding domain (IBD) is observed only upon transition from a diphosphate to a triphosphate nucleotide. The role of a magnesium ion during the GDP and GTP-bound states has also been observed. The binding of magnesium in the nucleotide site causes the reorientation of the beta- and gamma- phosphate groups toward the jaws of the P-loop and stabilizes the binding of the nucleotide, creating a network of hydrogen and water-bridge interactions.

-	~~Authors: Ataide, S~~.F., Faoro, C.	+	Structural insights into the G-loop dynamics of E. coli FtsY NG domain.,Faoro C, Ataide SF J Struct Biol. 2019 Sep 11. pii: S1047-8477(19)30198-4. doi:, 10.1016/j.jsb.2019.09.004. PMID:31520694<ref>PMID:31520694</ref>

-	~~Description: FtsY~~-~~NG ultra high~~-~~resolution~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Ataide, S.F]]	+	<div class="pdbe-citations 6n9b" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ataide, S F]]
	[[Category: Faoro, C]]		[[Category: Faoro, C]]
		+	[[Category: Ftsy]]
		+	[[Category: Signal recognition particle receptor]]
		+	[[Category: Sr]]
		+	[[Category: Srp]]
		+	[[Category: Transport protein]]

OCA at 10:33, 16 January 2019

OCA — Wed, 16 Jan 2019 10:33:58 GMT

←Older revision		Revision as of 10:33, 16 January 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n9b is ON HOLD	+	The entry 6n9b is ON HOLD until Paper Publication

	Authors: Ataide, S.F., Faoro, C.		Authors: Ataide, S.F., Faoro, C.

OCA: Protected "6n9b" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2018 05:22:38 GMT

Protected "6n9b" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:22, 12 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n9b is ON HOLD Authors: Ataide, S.F., Faoro, C. Description: FtsY-NG ultra high-resolution Category: Unreleased Structures [[Category: Ataide,...

OCA — Wed, 12 Dec 2018 05:22:36 GMT

New page: '''Unreleased structure''' The entry 6n9b is ON HOLD Authors: Ataide, S.F., Faoro, C. Description: FtsY-NG ultra high-resolution Category: Unreleased Structures [[Category: Ataide,...

New page

'''Unreleased structure'''

The entry 6n9b is ON HOLD

Authors: Ataide, S.F., Faoro, C.

Description: FtsY-NG ultra high-resolution
[[Category: Unreleased Structures]]
[[Category: Ataide, S.F]]
[[Category: Faoro, C]]