6nbn - Revision history

OCA at 10:55, 14 June 2023

OCA — Wed, 14 Jun 2023 10:55:29 GMT

←Older revision		Revision as of 10:55, 14 June 2023
Line 1:		Line 1:

	==Structure of Aedes aegypti OBP22 in the complex with arachidonic acid==		==Structure of Aedes aegypti OBP22 in the complex with arachidonic acid==
-	<StructureSection load='6nbn' size='340' side='right'caption='[[6nbn~~]], [[NMR_Ensembles_of_Models \| 30 NMR models~~]]' scene=''>	+	<StructureSection load='6nbn' size='340' side='right'caption='[[6nbn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nbn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aedae Aedae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6NBN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nbn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NBN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5567053, AAEL005772 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbn OCA], [https://pdbe.org/6nbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nbn RCSB], [https://www.ebi.ac.uk/pdbsum/6nbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6nbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbn OCA], [~~http~~://pdbe.org/6nbn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6nbn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6nbn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbn ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q1HRL7_AEDAE Q1HRL7_AEDAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aedae~~]]	+	[[Category: Aedes aegypti]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jones~~, D N~~]]	+	[[Category: Jones DN]]
-	[[Category: Wang, J]]	+	[[Category: Wang J]]
-	~~[[Category: Odorant-binding protein chemo-sensory signaling lipid binding]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 06:29, 6 May 2020

OCA — Wed, 06 May 2020 06:29:21 GMT

←Older revision		Revision as of 06:29, 6 May 2020
Line 3:		Line 3:
	<StructureSection load='6nbn' size='340' side='right'caption='[[6nbn]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='6nbn' size='340' side='right'caption='[[6nbn]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nbn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NBN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nbn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6NBN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5567053, AAEL005772 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5567053, AAEL005772 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbn OCA], [http://pdbe.org/6nbn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nbn RCSB], [http://www.ebi.ac.uk/pdbsum/6nbn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6nbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbn OCA], [http://pdbe.org/6nbn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nbn RCSB], [http://www.ebi.ac.uk/pdbsum/6nbn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbn ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aedes aegypti is the primary vector for transmission of Dengue, Zika and chikungunya viruses. Previously it was shown that Dengue virus infection of the mosquito led to an in increased expression of the odorant binding protein 22 (AeOBP22) within the mosquito salivary gland and that siRNA mediated knockdown of AeOBP22 led to reduced mosquito feeding behaviors. Insect OBPs are implicated in the perception, storage and transport of chemosensory signaling molecules including air-borne odorants and pheromones. AeOBP22 is unusual as it is additionally expressed in multiple tissues, including the antenna, the male reproductive glands and is transferred to females during reproduction, indicating multiple roles in the mosquito life cycle. However, it is unclear what role it plays in these tissues and what ligands it interacts with. Here we present solution and X-ray crystallographic studies that indicate a potential role of AeOBP22 binding to fatty acids, and that the specificity for longer chain fatty acids is regulated by a conformational change in the C-terminal tail that leads to creation of an enlarged binding cavity that enhances binding affinity. This study sheds light onto the native ligands for AeOBP22 and provides insight into its potential functions in different tissues.
		+
		+	Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail.,Wang J, Murphy EJ, Nix JC, Jones DNM Sci Rep. 2020 Feb 24;10(1):3300. doi: 10.1038/s41598-020-60242-9. PMID:32094450<ref>PMID:32094450</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6nbn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Odorant binding protein 3D structures\|Odorant binding protein 3D structures]]		*[[Odorant binding protein 3D structures\|Odorant binding protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:24, 18 December 2019

OCA — Wed, 18 Dec 2019 11:24:41 GMT

←Older revision		Revision as of 11:24, 18 December 2019
Line 1:		Line 1:

	==Structure of Aedes aegypti OBP22 in the complex with arachidonic acid==		==Structure of Aedes aegypti OBP22 in the complex with arachidonic acid==
-	<StructureSection load='6nbn' size='340' side='right' caption='[[6nbn]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>	+	<StructureSection load='6nbn' size='340' side='right'caption='[[6nbn]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nbn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NBN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nbn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NBN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5567053, AAEL005772 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbn OCA], [http://pdbe.org/6nbn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nbn RCSB], [http://www.ebi.ac.uk/pdbsum/6nbn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbn OCA], [http://pdbe.org/6nbn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nbn RCSB], [http://www.ebi.ac.uk/pdbsum/6nbn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbn ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Odorant binding protein 3D structures\|Odorant binding protein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aedae]]
		+	[[Category: Large Structures]]
	[[Category: Jones, D N]]		[[Category: Jones, D N]]
	[[Category: Wang, J]]		[[Category: Wang, J]]
	[[Category: Odorant-binding protein chemo-sensory signaling lipid binding]]		[[Category: Odorant-binding protein chemo-sensory signaling lipid binding]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA: Protected "6nbn" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2018 08:37:25 GMT

Protected "6nbn" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:37, 19 December 2018

OCA: New page: ==Structure of Aedes aegypti OBP22 in the complex with arachidonic acid== == Structural highlights ==
<table><tr><td colspan='2'>[[6nbn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NBN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbn OCA], [http://pdbe.org/6nbn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nbn RCSB], [http://www.ebi.ac.uk/pdbsum/6nbn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbn ProSAT]</span></td></tr>
</table>
TOC
</StructureSection>
[[Category: Jones, D N]]
[[Category: Wang, J]]
[[Category: Odorant-binding protein chemo-sensory signaling lipid binding]]
[[Category: Transport protein]]