6nda - Revision history

OCA at 06:50, 11 October 2023

OCA — Wed, 11 Oct 2023 06:50:24 GMT

←Older revision		Revision as of 06:50, 11 October 2023
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	==RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM==		==RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM==
-	<StructureSection load='6nda' size='340' side='right' caption='[[6nda]], [[Resolution\|resolution]] 3.15Å' scene=''>	+	<StructureSection load='6nda' size='340' side='right'caption='[[6nda]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nda]] is a 18 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/ ] and [~~http~~://en.wikipedia.org/wiki/~~Calloselasma_rhodostoma Calloselasma rhodostoma~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NDA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nda]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NDA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.15Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nda OCA], [~~http~~://pdbe.org/6nda PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6nda RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6nda PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6nda ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nda OCA], [https://pdbe.org/6nda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nda RCSB], [https://www.ebi.ac.uk/pdbsum/6nda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SLEC_CALRH SLEC_CALRH]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref> [[~~http://www.uniprot.org/uniprot/ITA2_HUMAN ITA2_HUMAN~~]] Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. [[~~http://www.uniprot.org/uniprot/SLED_CALRH SLED_CALRH~~]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref>	+	[https://www.uniprot.org/uniprot/SLEC_CALRH SLEC_CALRH] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref>
		+
		+	==See Also==
		+	*[[Integrin 3D structures\|Integrin 3D structures]]
		+	*[[Rhodocetin\|Rhodocetin]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Calloselasma rhodostoma]]		[[Category: Calloselasma rhodostoma]]
-	[[Category: ~~Loewen, P C~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~McDougall, M D~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Stetefeld, J~~]]	+	[[Category: Loewen PC]]
-	[[Category: ~~C-type lectin~~]]	+	[[Category: McDougall MD]]
-	[[Category: ~~Cadmium]]~~	+	[[Category: Stetefeld J]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell adhesion-toxin complex]]~~	+
-	~~[[Category: Coagulation]]~~	+
-	~~[[Category: Integrin]]~~	+
-	~~[[Category: Venom~~]]	+

OCA at 08:27, 26 December 2018

OCA — Wed, 26 Dec 2018 08:27:10 GMT

←Older revision		Revision as of 08:27, 26 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6nda is ~~ON HOLD~~	+	==RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM==
-		+	<StructureSection load='6nda' size='340' side='right' caption='[[6nda]], [[Resolution\|resolution]] 3.15Å' scene=''>
-	~~Authors~~: ~~Stetefeld~~, J., ~~McDougall~~, M.D., ~~Loewen~~, P.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nda]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NDA FirstGlance]. <br>
-	~~Description~~: ~~RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2~~-~~A DOMAIN AND CADMIUM~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nda OCA], [http://pdbe.org/6nda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nda RCSB], [http://www.ebi.ac.uk/pdbsum/6nda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nda ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SLEC_CALRH SLEC_CALRH]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref> [[http://www.uniprot.org/uniprot/ITA2_HUMAN ITA2_HUMAN]] Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. [[http://www.uniprot.org/uniprot/SLED_CALRH SLED_CALRH]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Calloselasma rhodostoma]]
		+	[[Category: Loewen, P C]]
		+	[[Category: McDougall, M D]]
	[[Category: Stetefeld, J]]		[[Category: Stetefeld, J]]
-	[[Category: ~~Loewen, P.~~C]]	+	[[Category: C-type lectin]]
-	[[Category: ~~Mcdougall, M.D~~]]	+	[[Category: Cadmium]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell adhesion-toxin complex]]
		+	[[Category: Coagulation]]
		+	[[Category: Integrin]]
		+	[[Category: Venom]]

OCA: Protected "6nda" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2018 06:40:32 GMT

Protected "6nda" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:40, 19 December 2018

OCA: New page: '''Unreleased structure''' The entry 6nda is ON HOLD Authors: Stetefeld, J., McDougall, M.D., Loewen, P.C. Description: RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADM...

OCA — Wed, 19 Dec 2018 06:40:30 GMT

New page: '''Unreleased structure''' The entry 6nda is ON HOLD Authors: Stetefeld, J., McDougall, M.D., Loewen, P.C. Description: RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADM...

New page

'''Unreleased structure'''

The entry 6nda is ON HOLD

Authors: Stetefeld, J., McDougall, M.D., Loewen, P.C.

Description: RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM
[[Category: Unreleased Structures]]
[[Category: Stetefeld, J]]
[[Category: Loewen, P.C]]
[[Category: Mcdougall, M.D]]