OCA at 14:47, 13 March 2024

OCA — Wed, 13 Mar 2024 14:47:33 GMT

←Older revision		Revision as of 14:47, 13 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6nfo is ~~ON HOLD~~	+	==CYCLIC GMP-AMP SYNTHASE in complex with compound 20 inhibitor: 7-hydroxy-N-[(2S)-1-hydroxypropan-2-yl]-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide==
		+	<StructureSection load='6nfo' size='340' side='right'caption='[[6nfo]], [[Resolution\|resolution]] 2.93Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6nfo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5v8j 5v8j]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NFO FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.93Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KKM:7-hydroxy-N-[(2S)-1-hydroxypropan-2-yl]-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide'>KKM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfo OCA], [https://pdbe.org/6nfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nfo RCSB], [https://www.ebi.ac.uk/pdbsum/6nfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfo ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>

-	~~Authors:~~	+	==See Also==
-		+	*[[Cyclic GMP-AMP synthase 3D synthase\|Cyclic GMP-AMP synthase 3D synthase]]
-	~~Description~~:	+	== References ==
-	[[Category: ~~Unreleased~~ Structures]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Hall J]]

OCA at 04:54, 2 January 2019

OCA — Wed, 02 Jan 2019 04:54:10 GMT

←Older revision		Revision as of 04:54, 2 January 2019
Line 3:		Line 3:
	The entry 6nfo is ON HOLD		The entry 6nfo is ON HOLD

-	Authors: ~~Hall, J., Hall, J., Hall, J.~~	+	Authors:

-	Description: ~~Discovery of a high affinity inhibitor of cGAS~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Hall, J]]

OCA: Protected "6nfo" [edit=sysop:move=sysop]

OCA — Wed, 26 Dec 2018 06:52:19 GMT

Protected "6nfo" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:52, 26 December 2018

OCA: New page: '''Unreleased structure''' The entry 6nfo is ON HOLD Authors: Hall, J., Hall, J., Hall, J. Description: Discovery of a high affinity inhibitor of cGAS [[Category: Unreleased Structures...

OCA — Wed, 26 Dec 2018 06:52:18 GMT

New page: '''Unreleased structure''' The entry 6nfo is ON HOLD Authors: Hall, J., Hall, J., Hall, J. Description: Discovery of a high affinity inhibitor of cGAS [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 6nfo is ON HOLD

Authors: Hall, J., Hall, J., Hall, J.

Description: Discovery of a high affinity inhibitor of cGAS
[[Category: Unreleased Structures]]
[[Category: Hall, J]]

6nfo - Revision history

OCA at 14:47, 13 March 2024

OCA at 04:54, 2 January 2019

OCA: Protected "6nfo" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6nfo is ON HOLD Authors: Hall, J., Hall, J., Hall, J. Description: Discovery of a high affinity inhibitor of cGAS [[Category: Unreleased Structures...