6ng3 - Revision history

OCA at 06:53, 11 October 2023

OCA — Wed, 11 Oct 2023 06:53:02 GMT

←Older revision		Revision as of 06:53, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6ng3' size='340' side='right'caption='[[6ng3]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='6ng3' size='340' side='right'caption='[[6ng3]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ng3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NG3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NG3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ng3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NG3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.88Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNFRSF14, HVEA, HVEM, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ng3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ng3 OCA], [~~http~~://pdbe.org/6ng3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ng3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ng3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ng3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ng3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ng3 OCA], [https://pdbe.org/6ng3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ng3 RCSB], [https://www.ebi.ac.uk/pdbsum/6ng3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ng3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BY55_HUMAN BY55_HUMAN]] CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).[UniProtKB:O88875]<ref>PMID:11978774</ref> <ref>PMID:12486241</ref> <ref>PMID:16809620</ref> <ref>PMID:17307798</ref> <ref>PMID:18193050</ref> <ref>PMID:19109136</ref> <ref>PMID:25255144</ref> <ref>PMID:9973372</ref> CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.<ref>PMID:17237375</ref>	+	[https://www.uniprot.org/uniprot/BY55_HUMAN BY55_HUMAN] CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).[UniProtKB:O88875]<ref>PMID:11978774</ref> <ref>PMID:12486241</ref> <ref>PMID:16809620</ref> <ref>PMID:17307798</ref> <ref>PMID:18193050</ref> <ref>PMID:19109136</ref> <ref>PMID:25255144</ref> <ref>PMID:9973372</ref> CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.<ref>PMID:17237375</ref> [https://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Almo~~, S C~~]]	+	[[Category: Almo SC]]
-	[[Category: Bonanno, J]]	+	[[Category: Bonanno J]]
-	[[Category: Liu, W]]	+	[[Category: Liu W]]
-	~~[[Category: Btla]]~~	+
-	~~[[Category: Cd160]]~~	+
-	~~[[Category: Gd]]~~	+
-	~~[[Category: Hvem]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 06:28, 10 July 2019

OCA — Wed, 10 Jul 2019 06:28:42 GMT

←Older revision		Revision as of 06:28, 10 July 2019
Line 3:		Line 3:
	<StructureSection load='6ng3' size='340' side='right'caption='[[6ng3]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='6ng3' size='340' side='right'caption='[[6ng3]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ng3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NG3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ng3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NG3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNFRSF14, HVEA, HVEM, UNQ329/PRO509 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ng3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ng3 OCA], [http://pdbe.org/6ng3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ng3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ng3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ng3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ng3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ng3 OCA], [http://pdbe.org/6ng3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ng3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ng3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ng3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BY55_HUMAN BY55_HUMAN]] CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).[UniProtKB:O88875]<ref>PMID:11978774</ref> <ref>PMID:12486241</ref> <ref>PMID:16809620</ref> <ref>PMID:17307798</ref> <ref>PMID:18193050</ref> <ref>PMID:19109136</ref> <ref>PMID:25255144</ref> <ref>PMID:9973372</ref> CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.<ref>PMID:17237375</ref>		[[http://www.uniprot.org/uniprot/BY55_HUMAN BY55_HUMAN]] CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).[UniProtKB:O88875]<ref>PMID:11978774</ref> <ref>PMID:12486241</ref> <ref>PMID:16809620</ref> <ref>PMID:17307798</ref> <ref>PMID:18193050</ref> <ref>PMID:19109136</ref> <ref>PMID:25255144</ref> <ref>PMID:9973372</ref> CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.<ref>PMID:17237375</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD160 is a signaling molecule that interacts with herpes virus entry mediator (HVEM) and contributes to a wide range of immune responses, including T cell inhibition, natural killer cell activation, and mucosal immunity. GPI-anchored and transmembrane isoforms of CD160 share the same ectodomain responsible for HVEM engagement, which leads to bidirectional signaling. Despite the importance of the CD160:HVEM signaling axis and its therapeutic relevance, the structural and mechanistic basis underlying CD160-HVEM engagement has not been described. We report the crystal structures of the human CD160 extracellular domain and its complex with human HVEM. CD160 adopts a unique variation of the immunoglobulin fold and exists as a monomer in solution. The CD160:HVEM assembly exhibits a 1:1 stoichiometry and a binding interface similar to that observed in the BTLA:HVEM complex. Our work reveals the chemical and physical determinants underlying CD160:HVEM recognition and initiation of associated signaling processes.
		+
		+	Structural Basis of CD160:HVEM Recognition.,Liu W, Garrett SC, Fedorov EV, Ramagopal UA, Garforth SJ, Bonanno JB, Almo SC Structure. 2019 Jun 19. pii: S0969-2126(19)30172-8. doi:, 10.1016/j.str.2019.05.010. PMID:31230945<ref>PMID:31230945</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ng3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]

OCA at 05:55, 3 July 2019

OCA — Wed, 03 Jul 2019 05:55:10 GMT

←Older revision		Revision as of 05:55, 3 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ng3 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human CD160 and HVEM complex==
-		+	<StructureSection load='6ng3' size='340' side='right'caption='[[6ng3]], [[Resolution\|resolution]] 2.88Å' scene=''>
-	~~Authors~~: ~~Liu~~, W., ~~Bonanno~~, J., ~~Almo~~, S.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ng3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NG3 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of human~~ CD160 and ~~HVEM~~ complex	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ng3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ng3 OCA], [http://pdbe.org/6ng3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ng3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ng3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ng3 ProSAT]</span></td></tr>
-	[[Category: Almo, S.C]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BY55_HUMAN BY55_HUMAN]] CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).[UniProtKB:O88875]<ref>PMID:11978774</ref> <ref>PMID:12486241</ref> <ref>PMID:16809620</ref> <ref>PMID:17307798</ref> <ref>PMID:18193050</ref> <ref>PMID:19109136</ref> <ref>PMID:25255144</ref> <ref>PMID:9973372</ref> CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.<ref>PMID:17237375</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Almo, S C]]
		+	[[Category: Bonanno, J]]
	[[Category: Liu, W]]		[[Category: Liu, W]]
-	[[Category: ~~Bonanno, J~~]]	+	[[Category: Btla]]
		+	[[Category: Cd160]]
		+	[[Category: Gd]]
		+	[[Category: Hvem]]
		+	[[Category: Immune system]]

OCA at 21:03, 5 June 2019

OCA — Wed, 05 Jun 2019 21:03:15 GMT

←Older revision		Revision as of 21:03, 5 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ng3 is ON HOLD	+	The entry 6ng3 is ON HOLD until Paper Publication

	Authors: Liu, W., Bonanno, J., Almo, S.C.		Authors: Liu, W., Bonanno, J., Almo, S.C.

OCA at 05:43, 21 May 2019

OCA — Tue, 21 May 2019 05:43:08 GMT

←Older revision		Revision as of 05:43, 21 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ng3 is ON HOLD ~~until Paper Publication~~	+	The entry 6ng3 is ON HOLD

	Authors: Liu, W., Bonanno, J., Almo, S.C.		Authors: Liu, W., Bonanno, J., Almo, S.C.

OCA at 06:30, 30 January 2019

OCA — Wed, 30 Jan 2019 06:30:46 GMT

←Older revision		Revision as of 06:30, 30 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ng3 is ON HOLD	+	The entry 6ng3 is ON HOLD until Paper Publication

	Authors: Liu, W., Bonanno, J., Almo, S.C.		Authors: Liu, W., Bonanno, J., Almo, S.C.

OCA: Protected "6ng3" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2019 04:54:47 GMT

Protected "6ng3" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:54, 2 January 2019

OCA: New page: '''Unreleased structure''' The entry 6ng3 is ON HOLD Authors: Liu, W., Bonanno, J., Almo, S.C. Description: Crystal structure of human CD160 and HVEM complex [[Category: Unreleased Str...

OCA — Wed, 02 Jan 2019 04:54:46 GMT

New page: '''Unreleased structure''' The entry 6ng3 is ON HOLD Authors: Liu, W., Bonanno, J., Almo, S.C. Description: Crystal structure of human CD160 and HVEM complex [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 6ng3 is ON HOLD

Authors: Liu, W., Bonanno, J., Almo, S.C.

Description: Crystal structure of human CD160 and HVEM complex
[[Category: Unreleased Structures]]
[[Category: Almo, S.C]]
[[Category: Liu, W]]
[[Category: Bonanno, J]]