6nid - Revision history

OCA at 06:54, 11 October 2023

OCA — Wed, 11 Oct 2023 06:54:18 GMT

←Older revision		Revision as of 06:54, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6nid' size='340' side='right'caption='[[6nid]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='6nid' size='340' side='right'caption='[[6nid]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nid]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NID OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NID FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nid]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NID FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase]~~, ~~with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nid OCA], [~~http~~://pdbe.org/6nid PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6nid RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6nid PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6nid ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nid OCA], [https://pdbe.org/6nid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nid RCSB], [https://www.ebi.ac.uk/pdbsum/6nid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nid ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN]] Defects in CASK are the cause of mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) [MIM:[~~http~~://omim.org/entry/300749 300749]]. A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.<ref>PMID:19165920</ref> Defects in CASK are the cause of FG syndrome type 4 (FGS4) [MIM:[~~http~~://omim.org/entry/300422 300422]]. FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.<ref>PMID:19200522</ref> [[http://www.uniprot.org/uniprot/NRX1A_HUMAN NRX1A_HUMAN]] Pitt-Hopkins-like syndrome;NON RARE IN EUROPE: Autism. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility may be associated with variations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN] Defects in CASK are the cause of mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) [MIM:[https://omim.org/entry/300749 300749]. A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.<ref>PMID:19165920</ref> Defects in CASK are the cause of FG syndrome type 4 (FGS4) [MIM:[https://omim.org/entry/300422 300422]. FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.<ref>PMID:19200522</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN]] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. [[http://www.uniprot.org/uniprot/NRX1A_HUMAN NRX1A_HUMAN]] Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).	+	[https://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Fuentes EJ]]
-	[[Category: Fuentes~~, E J~~]]	+	[[Category: Gakhar L]]
-	[[Category: Gakhar, L]]	+	[[Category: Sun YJ]]
-	[[Category: Sun~~, Y J]]~~	+
-	~~[[Category: C-terminal peptide binding]]~~	+
-	~~[[Category: Maguk protein family]]~~	+
-	~~[[Category: Neurexin]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Peripheral plasma membrane protein]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein binding-peptide complex~~]]	+

OCA at 08:19, 1 January 2020

OCA — Wed, 01 Jan 2020 08:19:51 GMT

←Older revision		Revision as of 08:19, 1 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6nid is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK) PDZ domain in complex with Neurexin-1 peptide==
-		+	<StructureSection load='6nid' size='340' side='right'caption='[[6nid]], [[Resolution\|resolution]] 1.86Å' scene=''>
-	~~Authors~~: ~~Sun~~, Y.J., ~~Gakhar~~, L., ~~Fuentes~~, E.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nid]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NID FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of a ~~human calcium~~/~~calmodulin dependent serine protein kinase~~ (~~CASK~~) ~~PDZ domain~~ in ~~complex~~ with ~~Neurexin~~-1 ~~peptide~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nid OCA], [http://pdbe.org/6nid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nid RCSB], [http://www.ebi.ac.uk/pdbsum/6nid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nid ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN]] Defects in CASK are the cause of mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) [MIM:[http://omim.org/entry/300749 300749]]. A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.<ref>PMID:19165920</ref> Defects in CASK are the cause of FG syndrome type 4 (FGS4) [MIM:[http://omim.org/entry/300422 300422]]. FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.<ref>PMID:19200522</ref> [[http://www.uniprot.org/uniprot/NRX1A_HUMAN NRX1A_HUMAN]] Pitt-Hopkins-like syndrome;NON RARE IN EUROPE: Autism. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility may be associated with variations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSKP_HUMAN CSKP_HUMAN]] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. [[http://www.uniprot.org/uniprot/NRX1A_HUMAN NRX1A_HUMAN]] Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Fuentes, E J]]
	[[Category: Gakhar, L]]		[[Category: Gakhar, L]]
-	[[Category: Sun, Y.J]]	+	[[Category: Sun, Y J]]
-	[[Category: ~~Fuentes, E.J~~]]	+	[[Category: C-terminal peptide binding]]
		+	[[Category: Maguk protein family]]
		+	[[Category: Neurexin]]
		+	[[Category: Pdz domain]]
		+	[[Category: Peripheral plasma membrane protein]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein binding-peptide complex]]

OCA at 10:38, 16 January 2019

OCA — Wed, 16 Jan 2019 10:38:52 GMT

←Older revision		Revision as of 10:38, 16 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6nid is ON HOLD	+	The entry 6nid is ON HOLD until Paper Publication

	Authors: Sun, Y.J., Gakhar, L., Fuentes, E.J.		Authors: Sun, Y.J., Gakhar, L., Fuentes, E.J.

OCA: Protected "6nid" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2019 04:59:53 GMT

Protected "6nid" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:59, 2 January 2019

OCA: New page: '''Unreleased structure''' The entry 6nid is ON HOLD Authors: Sun, Y.J., Gakhar, L., Fuentes, E.J. Description: Crystal structure of a human calcium/calmodulin dependent serine protein...

OCA — Wed, 02 Jan 2019 04:59:51 GMT

New page: '''Unreleased structure''' The entry 6nid is ON HOLD Authors: Sun, Y.J., Gakhar, L., Fuentes, E.J. Description: Crystal structure of a human calcium/calmodulin dependent serine protein...

New page

'''Unreleased structure'''

The entry 6nid is ON HOLD

Authors: Sun, Y.J., Gakhar, L., Fuentes, E.J.

Description: Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK) PDZ domain in complex with Neurexin-1 peptide
[[Category: Unreleased Structures]]
[[Category: Gakhar, L]]
[[Category: Sun, Y.J]]
[[Category: Fuentes, E.J]]