6nm4 - Revision history

OCA at 06:56, 11 October 2023

OCA — Wed, 11 Oct 2023 06:56:11 GMT

←Older revision		Revision as of 06:56, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6nm4' size='340' side='right'caption='[[6nm4]], [[Resolution\|resolution]] 2.58Å' scene=''>		<StructureSection load='6nm4' size='340' side='right'caption='[[6nm4]], [[Resolution\|resolution]] 2.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nm4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NM4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nm4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NM4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KS7:4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane'>KS7</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.58Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRDM9, PFM6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KS7:4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane'>KS7</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nm4 OCA], [https://pdbe.org/6nm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nm4 RCSB], [https://www.ebi.ac.uk/pdbsum/6nm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nm4 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nm4 OCA], [~~http~~://pdbe.org/6nm4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6nm4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6nm4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6nm4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).	+	[https://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Histone-lysine N-methyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Brown~~, P J~~]]	+	[[Category: Brown PJ]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Edwards AM]]
-	[[Category: Fischer, C]]	+	[[Category: Fischer C]]
-	[[Category: Halabelian, L]]	+	[[Category: Halabelian L]]
-	[[Category: Ivanochko, D]]	+	[[Category: Ivanochko D]]
-	[[Category: Kattar~~, S D]]~~	+	[[Category: Kattar SD]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Sanders JM]]
-	[[Category: Sanders~~, J M]]~~	+
-	~~[[Category: Gene regulation-inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Lysine methyltransferase]]~~	+
-	~~[[Category: Pr set domain]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 13:03, 25 December 2019

OCA — Wed, 25 Dec 2019 13:03:36 GMT

←Older revision		Revision as of 13:03, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor==		==Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor==
-	<StructureSection load='6nm4' size='340' side='right' caption='[[6nm4]], [[Resolution\|resolution]] 2.58Å' scene=''>	+	<StructureSection load='6nm4' size='340' side='right'caption='[[6nm4]], [[Resolution\|resolution]] 2.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nm4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nm4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NM4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KS7:4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane'>KS7</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KS7:4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane'>KS7</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRDM9, PFM6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nm4 OCA], [http://pdbe.org/6nm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nm4 RCSB], [http://www.ebi.ac.uk/pdbsum/6nm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nm4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nm4 OCA], [http://pdbe.org/6nm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nm4 RCSB], [http://www.ebi.ac.uk/pdbsum/6nm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nm4 ProSAT]</span></td></tr>
Line 10:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).		[[http://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36. Its normal expression is restricted to germ cells and attenuation of its activity results in altered meiotic gene transcription, impairment of double-stranded breaks and pairing between homologous chromosomes. There is growing evidence for a role of aberrant expression of PRDM9 in oncogenesis and genome instability. Here we report the discovery of MRK-740, a potent (IC50: 80 +/- 16 nM), selective and cell-active PRDM9 inhibitor (Chemical Probe). MRK-740 binds in the substrate-binding pocket, with unusually extensive interactions with the cofactor S-adenosylmethionine (SAM), conferring SAM-dependent substrate-competitive inhibition. In cells, MRK-740 specifically and directly inhibits H3K4 methylation at endogenous PRDM9 target loci, whereas the closely related inactive control compound, MRK-740-NC, does not. The discovery of MRK-740 as a chemical probe for the PRDM subfamily of methyltransferases highlights the potential for exploiting SAM in targeting SAM-dependent methyltransferases.
		+
		+	Discovery of a chemical probe for PRDM9.,Allali-Hassani A, Szewczyk MM, Ivanochko D, Organ SL, Bok J, Ho JSY, Gay FPH, Li F, Blazer L, Eram MS, Halabelian L, Dilworth D, Luciani GM, Lima-Fernandes E, Wu Q, Loppnau P, Palmer N, Talib SZA, Brown PJ, Schapira M, Kaldis P, O'Hagan RC, Guccione E, Barsyte-Lovejoy D, Arrowsmith CH, Sanders JM, Kattar SD, Bennett DJ, Nicholson B, Vedadi M Nat Commun. 2019 Dec 17;10(1):5759. doi: 10.1038/s41467-019-13652-x. PMID:31848333<ref>PMID:31848333</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6nm4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 09:37, 13 February 2019

OCA — Wed, 13 Feb 2019 09:37:05 GMT

←Older revision		Revision as of 09:37, 13 February 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6nm4 ~~is ON HOLD~~	+	==Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor==
-		+	<StructureSection load='6nm4' size='340' side='right' caption='[[6nm4]], [[Resolution\|resolution]] 2.58Å' scene=''>
-	~~Authors~~: ~~Ivanochko, D~~., ~~Halabelian~~, L., ~~Fischer~~, C., ~~Sanders~~, J.M., ~~Kattar, S~~.D.~~, Brown, P~~.J., ~~Edwards, A~~.M., ~~Bountra~~, C., ~~Arrowsmith, C~~.H., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nm4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NM4 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~SAM~~-~~bound PRDM9 in complex with MRK~~-~~740 inhibitor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KS7:4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane'>KS7</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
-	[[Category: Arrowsmith, C.H]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nm4 OCA], [http://pdbe.org/6nm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nm4 RCSB], [http://www.ebi.ac.uk/pdbsum/6nm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nm4 ProSAT]</span></td></tr>
-	[[Category: Brown, P.J]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Histone-lysine N-methyltransferase]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Brown, P J]]
		+	[[Category: Edwards, A M]]
	[[Category: Fischer, C]]		[[Category: Fischer, C]]
	[[Category: Halabelian, L]]		[[Category: Halabelian, L]]
	[[Category: Ivanochko, D]]		[[Category: Ivanochko, D]]
-	[[Category: ~~Edwards~~, ~~A.M~~]]	+	[[Category: Kattar, S D]]
-	[[Category: Structural ~~Genomics Consortium (Sgc)~~]]	+	[[Category: Structural genomic]]
-	[[Category: ~~Kattar~~, ~~S.D~~]]	+	[[Category: Sanders, J M]]
-	[[Category: ~~Sanders, J.M~~]]	+	[[Category: Gene regulation-inhibitor complex]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Inhibitor]]
		+	[[Category: Lysine methyltransferase]]
		+	[[Category: Pr set domain]]
		+	[[Category: Sgc]]

OCA at 06:35, 30 January 2019

OCA — Wed, 30 Jan 2019 06:35:08 GMT

←Older revision		Revision as of 06:35, 30 January 2019
Line 3:		Line 3:
	The entry 6nm4 is ON HOLD		The entry 6nm4 is ON HOLD

-	Authors: Ivanochko, D., Halabelian, L., Fischer, C., Sanders, J.M., Kattar, S.D., Brown, P.J., Edwards, A.M., Bountra, C., Arrowsmith, C.H.	+	Authors: Ivanochko, D., Halabelian, L., Fischer, C., Sanders, J.M., Kattar, S.D., Brown, P.J., Edwards, A.M., Bountra, C., Arrowsmith, C.H., Structural Genomics Consortium (SGC)

	Description: Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor		Description: Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ivanochko, D]]
-	[[Category: Edwards, A.M]]
	[[Category: Arrowsmith, C.H]]		[[Category: Arrowsmith, C.H]]
	[[Category: Brown, P.J]]		[[Category: Brown, P.J]]
	[[Category: Fischer, C]]		[[Category: Fischer, C]]
	[[Category: Halabelian, L]]		[[Category: Halabelian, L]]
		+	[[Category: Ivanochko, D]]
		+	[[Category: Edwards, A.M]]
		+	[[Category: Structural Genomics Consortium (Sgc)]]
	[[Category: Kattar, S.D]]		[[Category: Kattar, S.D]]
	[[Category: Sanders, J.M]]		[[Category: Sanders, J.M]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA: Protected "6nm4" [edit=sysop:move=sysop]

OCA — Wed, 16 Jan 2019 10:45:57 GMT

Protected "6nm4" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:45, 16 January 2019

OCA: New page: '''Unreleased structure''' The entry 6nm4 is ON HOLD Authors: Ivanochko, D., Halabelian, L., Fischer, C., Sanders, J.M., Kattar, S.D., Brown, P.J., Edwards, A.M., Bountra, C., Arrowsmit...

OCA — Wed, 16 Jan 2019 10:45:56 GMT

New page: '''Unreleased structure''' The entry 6nm4 is ON HOLD Authors: Ivanochko, D., Halabelian, L., Fischer, C., Sanders, J.M., Kattar, S.D., Brown, P.J., Edwards, A.M., Bountra, C., Arrowsmit...

New page

'''Unreleased structure'''

The entry 6nm4 is ON HOLD

Authors: Ivanochko, D., Halabelian, L., Fischer, C., Sanders, J.M., Kattar, S.D., Brown, P.J., Edwards, A.M., Bountra, C., Arrowsmith, C.H.

Description: Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor
[[Category: Unreleased Structures]]
[[Category: Ivanochko, D]]
[[Category: Edwards, A.M]]
[[Category: Arrowsmith, C.H]]
[[Category: Brown, P.J]]
[[Category: Fischer, C]]
[[Category: Halabelian, L]]
[[Category: Kattar, S.D]]
[[Category: Sanders, J.M]]
[[Category: Bountra, C]]