6nmj - Revision history

OCA at 06:56, 11 October 2023

OCA — Wed, 11 Oct 2023 06:56:20 GMT

←Older revision		Revision as of 06:56, 11 October 2023
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	<StructureSection load='6nmj' size='340' side='right'caption='[[6nmj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6nmj' size='340' side='right'caption='[[6nmj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nmj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NMJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nmj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NMJ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6nmg\|6nmg]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Ric8a, rCG_48458 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nmj OCA], [https://pdbe.org/6nmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nmj RCSB], [https://www.ebi.ac.uk/pdbsum/6nmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nmj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nmj OCA], [~~http~~://pdbe.org/6nmj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6nmj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6nmj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6nmj ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B1H241_RAT B1H241_RAT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mou, T C~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Sprang, S R~~]]	+	[[Category: Mou TC]]
-	[[Category: ~~Zeng, B~~]]	+	[[Category: Sprang SR]]
-	[[Category: ~~Signaling protein~~]]	+	[[Category: Zeng B]]

OCA at 11:41, 1 January 2020

OCA — Wed, 01 Jan 2020 11:41:56 GMT

←Older revision		Revision as of 11:41, 1 January 2020
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	<StructureSection load='6nmj' size='340' side='right'caption='[[6nmj]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6nmj' size='340' side='right'caption='[[6nmj]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nmj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nmj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NMJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6nmg\|6nmg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6nmg\|6nmg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ric8a, rCG_48458 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nmj OCA], [http://pdbe.org/6nmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nmj RCSB], [http://www.ebi.ac.uk/pdbsum/6nmj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nmj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nmj OCA], [http://pdbe.org/6nmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nmj RCSB], [http://www.ebi.ac.uk/pdbsum/6nmj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nmj ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ric-8A is a 530-amino acid cytoplasmic molecular chaperone and guanine nucleotide exchange factor (GEF) for i, q, and 12/13 classes of heterortrimeric G protein alpha subunits (Galpha). We report the 2.2-A crystal structure of the Ric-8A Galpha-binding domain with GEF activity, residues 1-452, and is phosphorylated at Ser435 and Thr440. Residues 1-429 adopt a superhelical fold comprised of Armadillo (ARM) and HEAT repeats, and the C terminus is disordered. One of the phosphorylated residues potentially binds to a basic cluster in an ARM motif. Amino acid sequence conservation and published hydrogen-deuterium exchange data indicate repeats 3 through 6 to be a putative Galpha-binding surface. Normal mode modeling of small-angle X-ray scattering data indicates that phosphorylation induces relative rotation between repeats 1-4, 5-6, and 7-9. 2D (1)H-(15)N-TROSY spectra of [(2)H,(15)N]-labeled Galphai1 in the presence of R452 reveals chemical shift perturbations of the C terminus and Galphai1 residues involved in nucleotide binding.
		+
		+	Structure, Function, and Dynamics of the Galpha Binding Domain of Ric-8A.,Zeng B, Mou TC, Doukov TI, Steiner A, Yu W, Papasergi-Scott M, Tall GG, Hagn F, Sprang SR Structure. 2019 Jul 2;27(7):1137-1147.e5. doi: 10.1016/j.str.2019.04.013. Epub, 2019 May 30. PMID:31155309<ref>PMID:31155309</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6nmj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mou, T C]]		[[Category: Mou, T C]]

OCA at 06:56, 26 June 2019

OCA — Wed, 26 Jun 2019 06:56:26 GMT

←Older revision		Revision as of 06:56, 26 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6nmj ~~is ON HOLD until 00 0001~~	+	==Crystal Structure of Rat Ric-8A G alpha binding domain, "Paratone-N Immersed"==
-		+	<StructureSection load='6nmj' size='340' side='right'caption='[[6nmj]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nmj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NMJ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6nmg\|6nmg]]</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nmj OCA], [http://pdbe.org/6nmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nmj RCSB], [http://www.ebi.ac.uk/pdbsum/6nmj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nmj ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mou, T C]]
		+	[[Category: Sprang, S R]]
		+	[[Category: Zeng, B]]
		+	[[Category: Signaling protein]]

OCA at 07:44, 10 May 2019

OCA — Fri, 10 May 2019 07:44:42 GMT

←Older revision		Revision as of 07:44, 10 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6nmj is ON HOLD until ~~Paper Publication~~	+	The entry 6nmj is ON HOLD until 00 0001

	Authors:		Authors:

OCA at 07:34, 13 February 2019

OCA — Wed, 13 Feb 2019 07:34:33 GMT

←Older revision		Revision as of 07:34, 13 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6nmj is ON HOLD	+	The entry 6nmj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6nmj" [edit=sysop:move=sysop]

OCA — Wed, 30 Jan 2019 06:35:37 GMT

Protected "6nmj" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:35, 30 January 2019

OCA: New page: '''Unreleased structure''' The entry 6nmj is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 30 Jan 2019 06:35:36 GMT

New page: '''Unreleased structure''' The entry 6nmj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6nmj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]