6now - Revision history

OCA at 06:57, 11 October 2023

OCA — Wed, 11 Oct 2023 06:57:13 GMT

←Older revision		Revision as of 06:57, 11 October 2023
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	<StructureSection load='6now' size='340' side='right'caption='[[6now]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='6now' size='340' side='right'caption='[[6now]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6now]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6NOW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6now]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NOW FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>AARS2, AARSL, KIAA1270 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.099Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine~~-~~-tRNA_ligase Alanine--tRNA ligase]~~, ~~with EC number~~ [~~http://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [https://pdbe.org/6now PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [https://www.ebi.ac.uk/pdbsum/6now PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [~~http~~://pdbe.org/6now PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6now PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Combined oxidative phosphorylation defect type 8;Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia;Ovarioleukodystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN] Combined oxidative phosphorylation defect type 8;Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia;Ovarioleukodystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]	+	[https://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6now" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6now" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alanine--tRNA ligase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kuhle, B]]	+	[[Category: Kuhle B]]
-	[[Category: Schimmel, P]]	+	[[Category: Schimmel P]]
-	~~[[Category: Alanyl-trna synthetase]]~~	+
-	~~[[Category: Alpha-beta domain]]~~	+
-	~~[[Category: C-terminal domain]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Mitochondria~~]]	+

OCA at 11:23, 29 July 2020

OCA — Wed, 29 Jul 2020 11:23:20 GMT

←Older revision		Revision as of 11:23, 29 July 2020
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-	==Human Alanyl-tRNA Synthetase C-Ala domain==	+	==Human Mitochondrial Alanyl-tRNA Synthetase C-Ala domain==
	<StructureSection load='6now' size='340' side='right'caption='[[6now]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='6now' size='340' side='right'caption='[[6now]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6now]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NOW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6now]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6NOW FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine--tRNA_ligase Alanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AARS2, AARSL, KIAA1270 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [http://pdbe.org/6now PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [http://www.ebi.ac.uk/pdbsum/6now PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine--tRNA_ligase Alanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [http://pdbe.org/6now PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [http://www.ebi.ac.uk/pdbsum/6now PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]		[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Metazoan complexity and life-style depend on the bioenergetic potential of mitochondria. However, higher aerobic activity and genetic drift impose strong mutation pressure and risk of irreversible fitness decline in mitochondrial (mt)DNA-encoded genes. Bilaterian mitochondria-encoded tRNA genes, key players in mitochondrial activity, have accumulated mutations at significantly higher rates than their cytoplasmic counterparts, resulting in foreshortened and fragile structures. Here we show that fragility of mt tRNAs coincided with the evolution of bilaterian animals. We demonstrate that bilaterians compensated for this reduced structural complexity in mt tRNAs by sequence-independent induced-fit adaption to the cognate mitochondrial aminoacyl-tRNA synthetase (aaRS). Structural readout by nuclear-encoded aaRS partners relaxed the sequence constraints on mt tRNAs and facilitated accommodation of functionally disruptive mutational insults by cis-acting epistatic compensations. Our results thus suggest that mutational freedom in mt tRNA genes is an adaptation to increased mutation pressure that was associated with the evolution of animal complexity.
		+
		+	Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.,Kuhle B, Chihade J, Schimmel P Nat Commun. 2020 Feb 20;11(1):969. doi: 10.1038/s41467-020-14725-y. PMID:32080176<ref>PMID:32080176</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6now" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Alanine--tRNA ligase]]		[[Category: Alanine--tRNA ligase]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kuhle, B]]		[[Category: Kuhle, B]]

OCA at 16:11, 22 January 2020

OCA — Wed, 22 Jan 2020 16:11:18 GMT

←Older revision		Revision as of 16:11, 22 January 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6now is ~~ON HOLD until Paper Publication~~	+	==Human Alanyl-tRNA Synthetase C-Ala domain==
-		+	<StructureSection load='6now' size='340' side='right'caption='[[6now]], [[Resolution\|resolution]] 4.10Å' scene=''>
-	~~Authors~~: ~~Kuhle~~, B., ~~Schimmel~~, P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6now]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NOW FirstGlance]. <br>
-	~~Description~~: ~~Human Alanyl-~~tRNA ~~Synthetase C~~-Ala domain	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine--tRNA_ligase Alanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [http://pdbe.org/6now PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [http://www.ebi.ac.uk/pdbsum/6now PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Combined oxidative phosphorylation defect type 8;Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia;Ovarioleukodystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alanine--tRNA ligase]]
		+	[[Category: Large Structures]]
		+	[[Category: Kuhle, B]]
	[[Category: Schimmel, P]]		[[Category: Schimmel, P]]
-	[[Category: ~~Kuhle, B~~]]	+	[[Category: Alanyl-trna synthetase]]
		+	[[Category: Alpha-beta domain]]
		+	[[Category: C-terminal domain]]
		+	[[Category: Ligase]]
		+	[[Category: Mitochondria]]

OCA at 07:36, 13 February 2019

OCA — Wed, 13 Feb 2019 07:36:13 GMT

←Older revision		Revision as of 07:36, 13 February 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6now is ON HOLD	+	The entry 6now is ON HOLD until Paper Publication

	Authors: Kuhle, B., Schimmel, P.		Authors: Kuhle, B., Schimmel, P.

OCA: Protected "6now" [edit=sysop:move=sysop]

OCA — Wed, 30 Jan 2019 06:41:30 GMT

Protected "6now" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:41, 30 January 2019

OCA: New page: '''Unreleased structure''' The entry 6now is ON HOLD Authors: Kuhle, B., Schimmel, P. Description: Human Alanyl-tRNA Synthetase C-Ala domain Category: Unreleased Structures [[Categ...

OCA — Wed, 30 Jan 2019 06:41:28 GMT

New page: '''Unreleased structure''' The entry 6now is ON HOLD Authors: Kuhle, B., Schimmel, P. Description: Human Alanyl-tRNA Synthetase C-Ala domain Category: Unreleased Structures [[Categ...

New page

'''Unreleased structure'''

The entry 6now is ON HOLD

Authors: Kuhle, B., Schimmel, P.

Description: Human Alanyl-tRNA Synthetase C-Ala domain
[[Category: Unreleased Structures]]
[[Category: Schimmel, P]]
[[Category: Kuhle, B]]