6nph - Revision history

OCA at 03:27, 11 April 2020

OCA — Sat, 11 Apr 2020 03:27:55 GMT

←Older revision		Revision as of 03:27, 11 April 2020
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	<SX load='6nph' size='340' side='right' viewer='molstar' caption='[[6nph]], [[Resolution\|resolution]] 2.90Å' scene=''>		<SX load='6nph' size='340' side='right' viewer='molstar' caption='[[6nph]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NPH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NPH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NPH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6NPH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">slc12a2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">slc12a2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nph OCA], [http://pdbe.org/6nph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nph RCSB], [http://www.ebi.ac.uk/pdbsum/6nph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nph ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nph OCA], [http://pdbe.org/6nph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nph RCSB], [http://www.ebi.ac.uk/pdbsum/6nph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nph ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:53, 6 March 2020

OCA — Fri, 06 Mar 2020 22:53:18 GMT

←Older revision		Revision as of 22:53, 6 March 2020
Line 1:		Line 1:

	==Structure of NKCC1 TM domain==		==Structure of NKCC1 TM domain==
-	<~~StructureSection~~ load='6nph' size='340' side='right'caption='[[6nph]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<SX load='6nph' size='340' side='right' viewer='molstar' caption='[[6nph]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6nph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NPH FirstGlance]. <br>		<table><tr><td colspan='2'>[[6nph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NPH FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 17:26, 14 August 2019

OCA — Wed, 14 Aug 2019 17:26:53 GMT

←Older revision		Revision as of 17:26, 14 August 2019
Line 3:		Line 3:
	<StructureSection load='6nph' size='340' side='right'caption='[[6nph]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='6nph' size='340' side='right'caption='[[6nph]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nph]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NPH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NPH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">slc12a2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nph OCA], [http://pdbe.org/6nph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nph RCSB], [http://www.ebi.ac.uk/pdbsum/6nph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nph ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nph OCA], [http://pdbe.org/6nph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nph RCSB], [http://www.ebi.ac.uk/pdbsum/6nph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nph ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cation-chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles in regulating cell volume, controlling ion absorption and secretion across epithelia, and maintaining intracellular chloride homeostasis. These transporters are primary targets for some of the most commonly prescribed drugs. Here we determined the cryo-electron microscopy structure of the Na-K-Cl cotransporter NKCC1, an extensively studied member of the CCC family, from Danio rerio. The structure defines the architecture of this protein family and reveals how cytosolic and transmembrane domains are strategically positioned for communication. Structural analyses, functional characterizations and computational studies reveal the ion-translocation pathway, ion-binding sites and key residues for transport activity. These results provide insights into ion selectivity, coupling and translocation, and establish a framework for understanding the physiological functions of CCCs and interpreting disease-related mutations.
		+
		+	Structure and mechanism of the cation-chloride cotransporter NKCC1.,Chew TA, Orlando BJ, Zhang J, Latorraca NR, Wang A, Hollingsworth SA, Chen DH, Dror RO, Liao M, Feng L Nature. 2019 Jul 31. pii: 10.1038/s41586-019-1438-2. doi:, 10.1038/s41586-019-1438-2. PMID:31367042<ref>PMID:31367042</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6nph" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Feng, L]]		[[Category: Feng, L]]

OCA at 06:22, 31 July 2019

OCA — Wed, 31 Jul 2019 06:22:16 GMT

←Older revision		Revision as of 06:22, 31 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6nph ~~is ON HOLD until Paper Publication~~	+	==Structure of NKCC1 TM domain==
-		+	<StructureSection load='6nph' size='340' side='right'caption='[[6nph]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nph]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NPH FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nph OCA], [http://pdbe.org/6nph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nph RCSB], [http://www.ebi.ac.uk/pdbsum/6nph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nph ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Feng, L]]
		+	[[Category: Liao, M F]]
		+	[[Category: Orlando, B]]
		+	[[Category: Zhang, J R]]
		+	[[Category: Membrane protein]]

OCA at 04:55, 27 March 2019

OCA — Wed, 27 Mar 2019 04:55:33 GMT

←Older revision		Revision as of 04:55, 27 March 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6nph is ON HOLD	+	The entry 6nph is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6nph" [edit=sysop:move=sysop]

OCA — Wed, 30 Jan 2019 06:43:05 GMT

Protected "6nph" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:43, 30 January 2019

OCA: New page: '''Unreleased structure''' The entry 6nph is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 30 Jan 2019 06:43:04 GMT

New page: '''Unreleased structure''' The entry 6nph is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6nph is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]