6nvb - Revision history

OCA at 07:00, 11 October 2023

OCA — Wed, 11 Oct 2023 07:00:23 GMT

←Older revision		Revision as of 07:00, 11 October 2023
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	<StructureSection load='6nvb' size='340' side='right'caption='[[6nvb]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='6nvb' size='340' side='right'caption='[[6nvb]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nvb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NVB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NVB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NVB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~>, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.636Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~KLK4, EMSP1, PRSS17, PSTS ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nvb OCA], [~~http~~://pdbe.org/6nvb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6nvb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6nvb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6nvb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nvb OCA], [https://pdbe.org/6nvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nvb RCSB], [https://www.ebi.ac.uk/pdbsum/6nvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nvb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[~~http~~://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>	+	[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[https://omim.org/entry/204700 204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref>	+	[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Involved in enamel formation.<ref>PMID:15235027</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6nvb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6nvb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kallikrein 3D structures\|Kallikrein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Buckle~~, A M~~]]	+	[[Category: Buckle AM]]
-	[[Category: McGowan, S]]	+	[[Category: McGowan S]]
-	[[Category: Riley~~, B T]]~~	+	[[Category: Riley BT]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Klk4]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 16:00, 28 August 2019

OCA — Wed, 28 Aug 2019 16:00:55 GMT

←Older revision		Revision as of 16:00, 28 August 2019
Line 1:		Line 1:

-	==Crystal structure of kallikrein-4==	+	==Crystal structure of the inhibitor-free form of the serine protease kallikrein-4==
	<StructureSection load='6nvb' size='340' side='right'caption='[[6nvb]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='6nvb' size='340' side='right'caption='[[6nvb]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 06:38, 21 August 2019

OCA — Wed, 21 Aug 2019 06:38:42 GMT

←Older revision		Revision as of 06:38, 21 August 2019
Line 3:		Line 3:
	<StructureSection load='6nvb' size='340' side='right'caption='[[6nvb]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='6nvb' size='340' side='right'caption='[[6nvb]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nvb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NVB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nvb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLK4, EMSP1, PRSS17, PSTS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nvb OCA], [http://pdbe.org/6nvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nvb RCSB], [http://www.ebi.ac.uk/pdbsum/6nvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nvb OCA], [http://pdbe.org/6nvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nvb RCSB], [http://www.ebi.ac.uk/pdbsum/6nvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nvb ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref>		[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kallikrein 4 (KLK4) is a serine protease that is predominantly expressed in the prostate and is overexpressed in prostate cancer. As such, it has gained attention as an attractive target for prostate cancer therapeutics. Currently, only liganded structures of KLK4 exist in the Protein Data Bank. Until now, inferences about the subtle structural changes in KLK4 upon ligand binding have been made by comparison to other liganded forms, rather than to an apo form. In this study, an inhibitor-free form of KLK4 was crystallized. The crystals obtained belonged to space group P1, contained four molecules in the asymmetric unit and diffracted to 1.64 A resolution. Interestingly, a nonstandard rotamer of the specificity-determining residue Asp189 was observed in all chains. This model will provide a useful unliganded structure for the future structure-guided design of KLK4 inhibitors.
		+
		+	Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.,Riley BT, Hoke DE, McGowan S, Buckle AM Acta Crystallogr F Struct Biol Commun. 2019 Aug 1;75(Pt 8):543-546. doi:, 10.1107/S2053230X19009610. Epub 2019 Jul 16. PMID:31397325<ref>PMID:31397325</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6nvb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Buckle, A M]]		[[Category: Buckle, A M]]

OCA at 10:47, 17 July 2019

OCA — Wed, 17 Jul 2019 10:47:46 GMT

←Older revision		Revision as of 10:47, 17 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6nvb is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of kallikrein-4==
-		+	<StructureSection load='6nvb' size='340' side='right'caption='[[6nvb]], [[Resolution\|resolution]] 1.64Å' scene=''>
-	~~Authors~~: ~~Riley~~, B.T., ~~Buckle~~, A.M., ~~McGowan~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nvb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NVB FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~kallikrein-4~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nvb OCA], [http://pdbe.org/6nvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nvb RCSB], [http://www.ebi.ac.uk/pdbsum/6nvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nvb ProSAT]</span></td></tr>
-	[[Category: Buckle, A.M]]	+	</table>
-	[[Category: Riley, B.T]]	+	== Disease ==
-	[[Category: ~~Mcgowan, S~~]]	+	[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Buckle, A M]]
		+	[[Category: McGowan, S]]
		+	[[Category: Riley, B T]]
		+	[[Category: Hydrolase]]
		+	[[Category: Klk4]]
		+	[[Category: Protease]]

OCA at 05:09, 21 February 2019

OCA — Thu, 21 Feb 2019 05:09:16 GMT

←Older revision		Revision as of 05:09, 21 February 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6nvb is ON HOLD	+	The entry 6nvb is ON HOLD until Paper Publication

	Authors: Riley, B.T., Buckle, A.M., McGowan, S.		Authors: Riley, B.T., Buckle, A.M., McGowan, S.

OCA: Protected "6nvb" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2019 07:49:05 GMT

Protected "6nvb" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:49, 13 February 2019

OCA: New page: '''Unreleased structure''' The entry 6nvb is ON HOLD Authors: Riley, B.T., Buckle, A.M., McGowan, S. Description: Crystal structure of kallikrein-4 Category: Unreleased Structures ...

OCA — Wed, 13 Feb 2019 07:49:04 GMT

New page: '''Unreleased structure''' The entry 6nvb is ON HOLD Authors: Riley, B.T., Buckle, A.M., McGowan, S. Description: Crystal structure of kallikrein-4 Category: Unreleased Structures ...

New page

'''Unreleased structure'''

The entry 6nvb is ON HOLD

Authors: Riley, B.T., Buckle, A.M., McGowan, S.

Description: Crystal structure of kallikrein-4
[[Category: Unreleased Structures]]
[[Category: Buckle, A.M]]
[[Category: Riley, B.T]]
[[Category: Mcgowan, S]]