6nxh - Revision history

OCA: Redirecting to 6o98

OCA — Wed, 20 Mar 2019 07:36:44 GMT

Redirecting to 6o98

←Older revision		Revision as of 07:36, 20 March 2019
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-		+	#REDIRECT [[6o98]] This PDB entry is obsolete and replaced by 6o98
-	~~==Crystal structure of RAR-related orphan receptor C (NHIS- RORgt(244-487)-L6-SRC1(678-692)) in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor==~~	+
-	~~<StructureSection load='6nxh' size='340' side='right'caption='~~[[~~6nxh]], [[Resolution\|resolution]] 1.90Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[6nxh~~]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NXH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NXH FirstGlance]. <br>	+
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=L8A:1-(4-{(3R)-3-[(4-fluorophenyl)sulfonyl]-3-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]pyrrolidine-1-carbonyl}piperazin-1-yl)ethan-1-one'>L8A</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6nx1\|6nx1]]</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nxh OCA], [http://pdbe.org/6nxh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nxh RCSB], [http://www.ebi.ac.uk/pdbsum/6nxh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nxh ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	~~[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis~~ and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Large Structures]]~~	+
-	~~[[Category: Sack, J]]~~	+
-	~~[[Category: Inverse agonist]]~~	+
-	~~[[Category: Ligand-binding domain]]~~	+
-	~~[[Category: Nuclear hormone receptor]]~~	+
-	~~[[Category: Rorgt]]~~	+
-	~~[[Category: Transcription-inhibitor complex]]~~	+

OCA at 12:23, 13 March 2019

OCA — Wed, 13 Mar 2019 12:23:09 GMT

←Older revision		Revision as of 12:23, 13 March 2019
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-	'''Unreleased structure'''

-	~~The entry 6nxh is ON HOLD until Paper Publication~~	+	==Crystal structure of RAR-related orphan receptor C (NHIS- RORgt(244-487)-L6-SRC1(678-692)) in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor==
-		+	<StructureSection load='6nxh' size='340' side='right'caption='[[6nxh]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~Authors: Sack, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nxh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NXH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NXH FirstGlance]. <br>
-	~~Description:~~ Crystal structure of RAR-related orphan receptor C (NHIS-RORgt(244-487)-L6-SRC1(~~6T78~~-692)) in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=L8A:1-(4-{(3R)-3-[(4-fluorophenyl)sulfonyl]-3-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]pyrrolidine-1-carbonyl}piperazin-1-yl)ethan-1-one'>L8A</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6nx1\|6nx1]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nxh OCA], [http://pdbe.org/6nxh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nxh RCSB], [http://www.ebi.ac.uk/pdbsum/6nxh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nxh ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Sack, J]]		[[Category: Sack, J]]
		+	[[Category: Inverse agonist]]
		+	[[Category: Ligand-binding domain]]
		+	[[Category: Nuclear hormone receptor]]
		+	[[Category: Rorgt]]
		+	[[Category: Transcription-inhibitor complex]]

OCA at 05:37, 6 March 2019

OCA — Wed, 06 Mar 2019 05:37:32 GMT

←Older revision		Revision as of 05:37, 6 March 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6nxh is ON HOLD	+	The entry 6nxh is ON HOLD until Paper Publication

	Authors: Sack, J.		Authors: Sack, J.

OCA: Protected "6nxh" [edit=sysop:move=sysop]

OCA — Thu, 21 Feb 2019 05:11:20 GMT

Protected "6nxh" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:11, 21 February 2019

OCA: New page: '''Unreleased structure''' The entry 6nxh is ON HOLD Authors: Sack, J. Description: Crystal structure of RAR-related orphan receptor C (NHIS-RORgt(244-487)-L6-SRC1(6T78-692)) in comple...

OCA — Thu, 21 Feb 2019 05:11:19 GMT

New page: '''Unreleased structure''' The entry 6nxh is ON HOLD Authors: Sack, J. Description: Crystal structure of RAR-related orphan receptor C (NHIS-RORgt(244-487)-L6-SRC1(6T78-692)) in comple...

New page

'''Unreleased structure'''

The entry 6nxh is ON HOLD

Authors: Sack, J.

Description: Crystal structure of RAR-related orphan receptor C (NHIS-RORgt(244-487)-L6-SRC1(6T78-692)) in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor
[[Category: Unreleased Structures]]
[[Category: Sack, J]]