6o02 - Revision history

OCA at 14:49, 13 March 2024

OCA — Wed, 13 Mar 2024 14:49:43 GMT

←Older revision		Revision as of 14:49, 13 March 2024
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-	====	+	==Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL==
-	<StructureSection load='6o02' size='340' side='right'caption='[[6o02]]' scene=''>	+	<StructureSection load='6o02' size='340' side='right'caption='[[6o02]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o02]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O02 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6o02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o02 OCA], [~~http~~://pdbe.org/6o02 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o02 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o02 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o02 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.953Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o02 OCA], [https://pdbe.org/6o02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o02 RCSB], [https://www.ebi.ac.uk/pdbsum/6o02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o02 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CBL_HUMAN CBL_HUMAN] Defects in CBL are the cause of Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL) [MIM:[https://omim.org/entry/613563 613563]. A syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable, including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects.<ref>PMID:20619386</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CBL_HUMAN CBL_HUMAN] Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.<ref>PMID:10514377</ref> <ref>PMID:11896602</ref> <ref>PMID:14739300</ref> <ref>PMID:15190072</ref> <ref>PMID:17509076</ref> <ref>PMID:18374639</ref> <ref>PMID:19689429</ref> <ref>PMID:21596750</ref>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Hantschel O]]
		+	[[Category: Kukenshoner T]]
		+	[[Category: Pojer F]]

OCA at 06:18, 19 August 2020

OCA — Wed, 19 Aug 2020 06:18:09 GMT

←Older revision		Revision as of 06:18, 19 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6o02 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6o02' size='340' side='right'caption='[[6o02]]' scene=''>
-	~~Authors~~: ~~Kukenshoner, T~~.~~, Pojer, F~~.~~, Hantschel, O~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o02 OCA], [http://pdbe.org/6o02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o02 RCSB], [http://www.ebi.ac.uk/pdbsum/6o02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o02 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Pojer~~, F]]	+	__TOC__
-	[[Category: ~~Kukenshoner, T~~]]	+	</StructureSection>
-	[[Category: ~~Hantschel, O~~]]	+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 10:08, 13 March 2019

OCA — Wed, 13 Mar 2019 10:08:58 GMT

←Older revision		Revision as of 10:08, 13 March 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6o02 is ON HOLD	+	The entry 6o02 is ON HOLD until Paper Publication

	Authors: Kukenshoner, T., Pojer, F., Hantschel, O.		Authors: Kukenshoner, T., Pojer, F., Hantschel, O.
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	Description: Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL		Description: Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Pojer, F]]
	[[Category: Kukenshoner, T]]		[[Category: Kukenshoner, T]]
	[[Category: Hantschel, O]]		[[Category: Hantschel, O]]
-	[[Category: Pojer, F]]

OCA: Protected "6o02" [edit=sysop:move=sysop]

OCA — Thu, 21 Feb 2019 05:18:06 GMT

Protected "6o02" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 21 February 2019

OCA: New page: '''Unreleased structure''' The entry 6o02 is ON HOLD Authors: Kukenshoner, T., Pojer, F., Hantschel, O. Description: Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiqui...

OCA — Thu, 21 Feb 2019 05:18:05 GMT

New page: '''Unreleased structure''' The entry 6o02 is ON HOLD Authors: Kukenshoner, T., Pojer, F., Hantschel, O. Description: Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiqui...

New page

'''Unreleased structure'''

The entry 6o02 is ON HOLD

Authors: Kukenshoner, T., Pojer, F., Hantschel, O.

Description: Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
[[Category: Unreleased Structures]]
[[Category: Kukenshoner, T]]
[[Category: Hantschel, O]]
[[Category: Pojer, F]]