6o3n - Revision history

OCA at 07:03, 11 October 2023

OCA — Wed, 11 Oct 2023 07:03:53 GMT

←Older revision		Revision as of 07:03, 11 October 2023
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	<StructureSection load='6o3n' size='340' side='right'caption='[[6o3n]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='6o3n' size='340' side='right'caption='[[6o3n]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o3n]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6O3N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o3n]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O3N FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ACE:ACETYL+GROUP'>ACE</scene~~>, ~~<scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6c4x\|6c4x]]~~, ~~[[6c4y\|6c4y]], [[6c4z\|6c4z]], [[6c50\|6c50]], [[6c51\|6c51]], [[6c52\|6c52]], [[6d02\|6d02]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6o3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3n OCA], [~~http~~://pdbe.org/6o3n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o3n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o3n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3n OCA], [https://pdbe.org/6o3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o3n RCSB], [https://www.ebi.ac.uk/pdbsum/6o3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~DeGrado, W F~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Liu, L~~]]	+	[[Category: DeGrado WF]]
-	[[Category: ~~Zhang, S Q~~]]	+	[[Category: Liu L]]
-	[[Category: ~~Alpha~~-~~amyloid]]~~	+	[[Category: Zhang S-Q]]
-	~~[[Category: Coiled-coil]]~~	+
-	~~[[Category: De novo design]]~~	+
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Fibril~~]]	+

OCA at 12:24, 13 March 2019

OCA — Wed, 13 Mar 2019 12:24:29 GMT

←Older revision		Revision as of 12:24, 13 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6o3n is ~~ON HOLD~~	+	==Cross-alpha Amyloid-like Structure alphaAmA==
		+	<StructureSection load='6o3n' size='340' side='right'caption='[[6o3n]], [[Resolution\|resolution]] 3.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6o3n]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O3N FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6c4x\|6c4x]], [[6c4y\|6c4y]], [[6c4z\|6c4z]], [[6c50\|6c50]], [[6c51\|6c51]], [[6c52\|6c52]], [[6d02\|6d02]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3n OCA], [http://pdbe.org/6o3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o3n RCSB], [http://www.ebi.ac.uk/pdbsum/6o3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3n ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Amyloids adopt 'cross-beta' structures composed of long, twisted fibrils with beta-strands running perpendicular to the fibril axis. Recently, a toxic peptide was proposed to form amyloid-like cross-alpha structures in solution, with a planar bilayer-like assembly observed in the crystal structure. Here we crystallographically characterize designed peptides that assemble into spiraling cross-alpha amyloid-like structures, which resemble twisted beta-amyloid fibrils. The peptides form helical dimers, stabilized by packing of small and apolar residues, and the dimers further assemble into cross-alpha amyloid-like fibrils with superhelical pitches ranging from 170 A to 200 A. When a small residue that appeared critical for packing was converted to leucine, it resulted in structural rearrangement to a helical polymer. Fluorescently tagged versions of the designed peptides form puncta in mammalian cells, which recover from photobleaching with markedly different kinetics. These structural folds could be potentially useful for directing in vivo protein assemblies with predetermined spacing and stabilities.

-	~~Authors: Zhang, S.~~-Q., Liu, L., DeGrado, W.F.	+	Designed peptides that assemble into cross-alpha amyloid-like structures.,Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF Nat Chem Biol. 2018 Jul 30. pii: 10.1038/s41589-018-0105-5. doi:, 10.1038/s41589-018-0105-5. PMID:30061717<ref>PMID:30061717</ref>

-	~~Description: Cross~~-~~alpha Amyloid~~-~~like Structure alphaAmA~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6o3n" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: DeGrado, W F]]
	[[Category: Liu, L]]		[[Category: Liu, L]]
-	[[Category: ~~Degrado~~, ~~W.F~~]]	+	[[Category: Zhang, S Q]]
-	[[Category: ~~Zhang, S.~~-Q]]	+	[[Category: Alpha-amyloid]]
		+	[[Category: Coiled-coil]]
		+	[[Category: De novo design]]
		+	[[Category: De novo protein]]
		+	[[Category: Fibril]]

OCA: Protected "6o3n" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2019 05:44:53 GMT

Protected "6o3n" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:44, 6 March 2019

OCA: New page: '''Unreleased structure''' The entry 6o3n is ON HOLD Authors: Zhang, S.-Q., Liu, L., DeGrado, W.F. Description: Cross-alpha Amyloid-like Structure alphaAmA [[Category: Unreleased Struc...

OCA — Wed, 06 Mar 2019 05:44:51 GMT

New page: '''Unreleased structure''' The entry 6o3n is ON HOLD Authors: Zhang, S.-Q., Liu, L., DeGrado, W.F. Description: Cross-alpha Amyloid-like Structure alphaAmA [[Category: Unreleased Struc...

New page

'''Unreleased structure'''

The entry 6o3n is ON HOLD

Authors: Zhang, S.-Q., Liu, L., DeGrado, W.F.

Description: Cross-alpha Amyloid-like Structure alphaAmA
[[Category: Unreleased Structures]]
[[Category: Liu, L]]
[[Category: Degrado, W.F]]
[[Category: Zhang, S.-Q]]