6o3w - Revision history

OCA at 07:04, 11 October 2023

OCA — Wed, 11 Oct 2023 07:04:03 GMT

←Older revision		Revision as of 07:04, 11 October 2023
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	<StructureSection load='6o3w' size='340' side='right'caption='[[6o3w]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6o3w' size='340' side='right'caption='[[6o3w]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o3w]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6O3W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o3w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O3W FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6o3x\|6o3x]], [[6o3y\|6o3y]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">NRD1, YNL251C, N0868 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3w OCA], [https://pdbe.org/6o3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o3w RCSB], [https://www.ebi.ac.uk/pdbsum/6o3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3w ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6o3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3w OCA], [~~http~~://pdbe.org/6o3w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o3w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o3w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3w ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SEN1_YEAST SEN1_YEAST]] ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs. Directs RNA polymerase II transcription termination on snoRNAs as well as on several short protein-coding genes. May also play a role in transcription-coupled nucleotide excision repair.<ref>PMID:11565036</ref> <ref>PMID:15121901</ref> <ref>PMID:17157256</ref> <ref>PMID:8943355</ref> <ref>PMID:9365256</ref> <ref>PMID:9819377</ref> ~~[[http://www.uniprot.org/uniprot/NRD1_YEAST NRD1_YEAST]] Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance.~~	+	[https://www.uniprot.org/uniprot/SEN1_YEAST SEN1_YEAST] ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs. Directs RNA polymerase II transcription termination on snoRNAs as well as on several short protein-coding genes. May also play a role in transcription-coupled nucleotide excision repair.<ref>PMID:11565036</ref> <ref>PMID:15121901</ref> <ref>PMID:17157256</ref> <ref>PMID:8943355</ref> <ref>PMID:9365256</ref> <ref>PMID:9819377</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6o3w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6o3w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Helicase 3D structures\|Helicase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Tong, L~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Zhang, Y~~]]	+	[[Category: Tong L]]
-	[[Category: ~~Cid]]~~	+	[[Category: Zhang Y]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Ctd mimic]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 12:39, 17 July 2019

OCA — Wed, 17 Jul 2019 12:39:54 GMT

←Older revision		Revision as of 12:39, 17 July 2019
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	<StructureSection load='6o3w' size='340' side='right'caption='[[6o3w]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6o3w' size='340' side='right'caption='[[6o3w]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o3w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O3W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o3w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O3W FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6o3x\|6o3x]], [[6o3y\|6o3y]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6o3x\|6o3x]], [[6o3y\|6o3y]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NRD1, YNL251C, N0868 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3w OCA], [http://pdbe.org/6o3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o3w RCSB], [http://www.ebi.ac.uk/pdbsum/6o3w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3w OCA], [http://pdbe.org/6o3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o3w RCSB], [http://www.ebi.ac.uk/pdbsum/6o3w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3w ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Tong, L]]		[[Category: Tong, L]]

OCA at 22:50, 5 June 2019

OCA — Wed, 05 Jun 2019 22:50:34 GMT

←Older revision		Revision as of 22:50, 5 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6o3w is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of yeast Nrd1 CID in complex with Sen1 NIM1==
		+	<StructureSection load='6o3w' size='340' side='right'caption='[[6o3w]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6o3w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O3W FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6o3x\|6o3x]], [[6o3y\|6o3y]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3w OCA], [http://pdbe.org/6o3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o3w RCSB], [http://www.ebi.ac.uk/pdbsum/6o3w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3w ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SEN1_YEAST SEN1_YEAST]] ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs. Directs RNA polymerase II transcription termination on snoRNAs as well as on several short protein-coding genes. May also play a role in transcription-coupled nucleotide excision repair.<ref>PMID:11565036</ref> <ref>PMID:15121901</ref> <ref>PMID:17157256</ref> <ref>PMID:8943355</ref> <ref>PMID:9365256</ref> <ref>PMID:9819377</ref> [[http://www.uniprot.org/uniprot/NRD1_YEAST NRD1_YEAST]] Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Nrd1-Nab3-Sen1 (NNS) complex carries out the transcription termination of non-coding RNAs (ncRNAs) by RNA polymerase II (Pol II) in yeast, although the detailed interactions among its subunits remain obscure. Here we have identified three sequence motifs in Sen1 that mediate direct interactions with the Pol II CTD interaction domain (CID) of Nrd1, determined the crystal structures of these Nrd1 interaction motifs (NIMs) bound to the CID, and characterized the interactions in vitro and in yeast. Removal of all three NIMs abolishes NNS complex formation and gives rise to ncRNA termination defects.

-	~~Authors~~:	+	Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1.,Zhang Y, Chun Y, Buratowski S, Tong L Structure. 2019 Apr 23. pii: S0969-2126(19)30127-3. doi:, 10.1016/j.str.2019.04.005. PMID:31104813<ref>PMID:31104813</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6o3w" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Tong, L]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Cid]]
		+	[[Category: Complex]]
		+	[[Category: Ctd mimic]]
		+	[[Category: Hydrolase]]

OCA at 10:11, 13 March 2019

OCA — Wed, 13 Mar 2019 10:11:02 GMT

←Older revision		Revision as of 10:11, 13 March 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6o3w is ON HOLD	+	The entry 6o3w is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6o3w" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2019 05:45:38 GMT

Protected "6o3w" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:45, 6 March 2019

OCA: New page: '''Unreleased structure''' The entry 6o3w is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Mar 2019 05:45:36 GMT

New page: '''Unreleased structure''' The entry 6o3w is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6o3w is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]