6o41 - Revision history

OCA at 07:04, 11 October 2023

OCA — Wed, 11 Oct 2023 07:04:08 GMT

←Older revision		Revision as of 07:04, 11 October 2023
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	<StructureSection load='6o41' size='340' side='right'caption='[[6o41]], [[Resolution\|resolution]] 2.46Å' scene=''>		<StructureSection load='6o41' size='340' side='right'caption='[[6o41]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o41]] is a 9 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Strsg Strsg~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O41 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6O41 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o41]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O41 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.465Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6o3d\|6o3d]]~~, [[~~6o3g~~\|~~6o3g]], [[6o3j\|6o3j]], [[6o3k\|6o3k]], [[6o3l\|6o3l]], [[6o3u\|6o3u]], [[6o42\|6o42~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~spg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=1320 STRSG])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o41 OCA], [https://pdbe.org/6o41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o41 RCSB], [https://www.ebi.ac.uk/pdbsum/6o41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o41 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6o41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o41 OCA], [~~http~~://pdbe.org/6o41 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o41 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o41 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o41 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6o41" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6o41" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Protein G\|Protein G]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strsg~~]]	+	[[Category: Streptococcus sp. 'group G']]
-	[[Category: Irimia, A]]	+	[[Category: Irimia A]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Broadly neutralising hiv-1 antibody]]~~	+
-	~~[[Category: Germline pgzl1 anti hiv-1]]~~	+
-	~~[[Category: Gp41 mper]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Membrane lipid~~]]	+

OCA at 18:41, 11 December 2019

OCA — Wed, 11 Dec 2019 18:41:42 GMT

←Older revision		Revision as of 18:41, 11 December 2019
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	<StructureSection load='6o41' size='340' side='right'caption='[[6o41]], [[Resolution\|resolution]] 2.46Å' scene=''>		<StructureSection load='6o41' size='340' side='right'caption='[[6o41]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o41]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O41 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o41]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Strsg Strsg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O41 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6o3d\|6o3d]], [[6o3g\|6o3g]], [[6o3j\|6o3j]], [[6o3k\|6o3k]], [[6o3l\|6o3l]], [[6o3u\|6o3u]], [[6o42\|6o42]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6o3d\|6o3d]], [[6o3g\|6o3g]], [[6o3j\|6o3j]], [[6o3k\|6o3k]], [[6o3l\|6o3l]], [[6o3u\|6o3u]], [[6o42\|6o42]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o41 OCA], [http://pdbe.org/6o41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o41 RCSB], [http://www.ebi.ac.uk/pdbsum/6o41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o41 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o41 OCA], [http://pdbe.org/6o41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o41 RCSB], [http://www.ebi.ac.uk/pdbsum/6o41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o41 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies of exceptional breadth. MPER antibodies usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors, are often from the minor IgG3 subclass, and some are polyreactive, such as 4E10. Here we describe an MPER broadly neutralizing antibody from the major IgG1 subclass, PGZL1, which shares germline V/D-region genes with 4E10, has a shorter CDRH3, and is less polyreactive. A recombinant sublineage variant pan-neutralizes a 130-isolate panel at 1.4 mug/ml (IC50). Notably, a germline revertant with mature CDR3s neutralizes 12% of viruses and still binds MPER after DJ reversion. Crystal structures of lipid-bound PGZL1 variants and cryo-EM reconstruction of an Env-PGZL1 complex reveal how these antibodies recognize MPER and viral membrane. Discovery of common genetic and structural elements among MPER antibodies from different patients suggests that such antibodies could be elicited using carefully designed immunogens.
		+
		+	An MPER antibody neutralizes HIV-1 using germline features shared among donors.,Zhang L, Irimia A, He L, Landais E, Rantalainen K, Leaman DP, Vollbrecht T, Stano A, Sands DI, Kim AS, Poignard P, Burton DR, Murrell B, Ward AB, Zhu J, Wilson IA, Zwick MB Nat Commun. 2019 Nov 26;10(1):5389. doi: 10.1038/s41467-019-12973-1. PMID:31772165<ref>PMID:31772165</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6o41" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Strsg]]
	[[Category: Irimia, A]]		[[Category: Irimia, A]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 08:11, 4 December 2019

OCA — Wed, 04 Dec 2019 08:11:45 GMT

←Older revision		Revision as of 08:11, 4 December 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6o41 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of the unbound PGZL1 germline Fab fragment (PGZL1_gVmDmJ)==
-		+	<StructureSection load='6o41' size='340' side='right'caption='[[6o41]], [[Resolution\|resolution]] 2.46Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6o41]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O41 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6o3d\|6o3d]], [[6o3g\|6o3g]], [[6o3j\|6o3j]], [[6o3k\|6o3k]], [[6o3l\|6o3l]], [[6o3u\|6o3u]], [[6o42\|6o42]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o41 OCA], [http://pdbe.org/6o41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o41 RCSB], [http://www.ebi.ac.uk/pdbsum/6o41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o41 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Irimia, A]]
		+	[[Category: Wilson, I A]]
		+	[[Category: Broadly neutralising hiv-1 antibody]]
		+	[[Category: Germline pgzl1 anti hiv-1]]
		+	[[Category: Gp41 mper]]
		+	[[Category: Immune system]]
		+	[[Category: Membrane lipid]]

OCA at 04:33, 3 April 2019

OCA — Wed, 03 Apr 2019 04:33:34 GMT

←Older revision		Revision as of 04:33, 3 April 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6o41 is ON HOLD	+	The entry 6o41 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6o41" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2019 05:45:57 GMT

Protected "6o41" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:45, 6 March 2019

OCA: New page: '''Unreleased structure''' The entry 6o41 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Mar 2019 05:45:56 GMT

New page: '''Unreleased structure''' The entry 6o41 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6o41 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]