6o6k - Revision history

OCA at 07:05, 11 October 2023

OCA — Wed, 11 Oct 2023 07:05:25 GMT

←Older revision		Revision as of 07:05, 11 October 2023
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	<StructureSection load='6o6k' size='340' side='right'caption='[[6o6k]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='6o6k' size='340' side='right'caption='[[6o6k]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o6k]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6O6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o6k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O6K FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~hupA (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=83333 ECOLI])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.601Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6k OCA], [~~http~~://pdbe.org/6o6k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o6k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o6k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6k OCA], [https://pdbe.org/6o6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o6k RCSB], [https://www.ebi.ac.uk/pdbsum/6o6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~DBHA_ECO57 DBHA_ECO57]~~] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.	+	[https://www.uniprot.org/uniprot/DBHA_ECOLI DBHA_ECOLI] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli]]
		+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hammel, M]]	+	[[Category: Hammel M]]
-	[[Category: Remesh~~, S G]]~~	+	[[Category: Remesh SG]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna binding protein-dna complex]]~~	+
-	~~[[Category: Dna supercoiling]]~~	+
-	~~[[Category: Histone like protein]]~~	+
-	~~[[Category: Nucleoid associated protein~~]]	+

OCA at 07:22, 30 September 2020

OCA — Wed, 30 Sep 2020 07:22:58 GMT

←Older revision		Revision as of 07:22, 30 September 2020
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	<StructureSection load='6o6k' size='340' side='right'caption='[[6o6k]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='6o6k' size='340' side='right'caption='[[6o6k]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6K OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6O6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o6k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6O6K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6k OCA], [http://pdbe.org/6o6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6k RCSB], [http://www.ebi.ac.uk/pdbsum/6o6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6k ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hupA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6k OCA], [http://pdbe.org/6o6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6k RCSB], [http://www.ebi.ac.uk/pdbsum/6o6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DBHA_ECO57 DBHA_ECO57]] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.		[[http://www.uniprot.org/uniprot/DBHA_ECO57 DBHA_ECO57]] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial nucleoid remodeling dependent on conserved histone-like protein, HU is one of the determining factors in global gene regulation. By imaging of near-native, unlabeled E. coli cells by soft X-ray tomography, we show that HU remodels nucleoids by promoting the formation of a dense condensed core surrounded by less condensed isolated domains. Nucleoid remodeling during cell growth and environmental adaptation correlate with pH and ionic strength controlled molecular switch that regulated HUalphaalpha dependent intermolecular DNA bundling. Through crystallographic and solution-based studies we show that these effects mechanistically rely on HUalphaalpha promiscuity in forming multiple electrostatically driven multimerization interfaces. Changes in DNA bundling consequently affects gene expression globally, likely by constrained DNA supercoiling. Taken together our findings unveil a critical function of HU-DNA interaction in nucleoid remodeling that may serve as a general microbial mechanism for transcriptional regulation to synchronize genetic responses during the cell cycle and adapt to changing environments.
		+
		+	Nucleoid remodeling during environmental adaptation is regulated by HU-dependent DNA bundling.,Remesh SG, Verma SC, Chen JH, Ekman AA, Larabell CA, Adhya S, Hammel M Nat Commun. 2020 Jun 9;11(1):2905. doi: 10.1038/s41467-020-16724-5. PMID:32518228<ref>PMID:32518228</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6o6k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hammel, M]]		[[Category: Hammel, M]]

OCA at 07:21, 11 March 2020

OCA — Wed, 11 Mar 2020 07:21:55 GMT

←Older revision		Revision as of 07:21, 11 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6o6k ~~is ON HOLD until Paper Publication~~	+	==HUaa 19bp SYM DNA pH 5.5==
-		+	<StructureSection load='6o6k' size='340' side='right'caption='[[6o6k]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6o6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O6K FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6k OCA], [http://pdbe.org/6o6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6k RCSB], [http://www.ebi.ac.uk/pdbsum/6o6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6k ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DBHA_ECO57 DBHA_ECO57]] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hammel, M]]
		+	[[Category: Remesh, S G]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna binding protein-dna complex]]
		+	[[Category: Dna supercoiling]]
		+	[[Category: Histone like protein]]
		+	[[Category: Nucleoid associated protein]]

OCA at 05:56, 20 March 2019

OCA — Wed, 20 Mar 2019 05:56:46 GMT

←Older revision		Revision as of 05:56, 20 March 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6o6k is ON HOLD	+	The entry 6o6k is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6o6k" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2019 10:17:22 GMT

Protected "6o6k" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:17, 13 March 2019

OCA: New page: '''Unreleased structure''' The entry 6o6k is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Mar 2019 10:17:20 GMT

New page: '''Unreleased structure''' The entry 6o6k is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6o6k is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]