6o6p - Revision history

OCA at 07:05, 11 October 2023

OCA — Wed, 11 Oct 2023 07:05:27 GMT

←Older revision		Revision as of 07:05, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6o6p' size='340' side='right'caption='[[6o6p]], [[Resolution\|resolution]] 3.85Å' scene=''>		<StructureSection load='6o6p' size='340' side='right'caption='[[6o6p]], [[Resolution\|resolution]] 3.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o6p]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6O6P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o6p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O6P FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Rv3208 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773~~ "~~Bacillus tuberculosis~~" ~~(Zopf 1883) Klein 1884~~])</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.851Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6o6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6p OCA], [~~http~~://pdbe.org/6o6p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o6p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o6p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6p OCA], [https://pdbe.org/6o6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o6p RCSB], [https://www.ebi.ac.uk/pdbsum/6o6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6p ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O05858_MYCTU O05858_MYCTU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6o6p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6o6p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]
		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Buschiazzo, A]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Gramajo, H]]	+	[[Category: Buschiazzo A]]
-	[[Category: Lara, J]]	+	[[Category: Gramajo H]]
-	[[Category: Larrieux, N]]	+	[[Category: Lara J]]
-	[[Category: Trajtenberg, F]]	+	[[Category: Larrieux N]]
-	~~[[Category: Fatty acid biosynthesis regulation]]~~	+	[[Category: Trajtenberg F]]
-	~~[[Category: Tetr-like transcription factor]]~~	+
-	~~[[Category: Transcription-dna complex~~]]	+

OCA at 11:23, 23 September 2020

OCA — Wed, 23 Sep 2020 11:23:43 GMT

←Older revision		Revision as of 11:23, 23 September 2020
Line 3:		Line 3:
	<StructureSection load='6o6p' size='340' side='right'caption='[[6o6p]], [[Resolution\|resolution]] 3.85Å' scene=''>		<StructureSection load='6o6p' size='340' side='right'caption='[[6o6p]], [[Resolution\|resolution]] 3.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o6p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6P OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6O6P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o6p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6O6P FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6o6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6p OCA], [http://pdbe.org/6o6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6p RCSB], [http://www.ebi.ac.uk/pdbsum/6o6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6p ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv3208 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6p OCA], [http://pdbe.org/6o6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6p RCSB], [http://www.ebi.ac.uk/pdbsum/6o6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6p ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis. Here we disclose crystal structures of M. tuberculosis FasR in complex with acyl effector ligands and with DNA, uncovering its molecular sensory and switching mechanisms. A long tunnel traverses the entire effector-binding domain, enabling long fatty acyl effectors to bind. Only when the tunnel is entirely occupied, the protein dimer adopts a rigid configuration with its DNA-binding domains in an open state, leading to DNA dissociation. The protein-folding hydrophobic core connects the two domains, and is completed into a continuous spine when the effector binds. Such a transmission spine is conserved in a large number of TetR-like regulators, offering insight into effector-triggered allosteric functional control.
		+
		+	Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine.,Lara J, Diacovich L, Trajtenberg F, Larrieux N, Malchiodi EL, Fernandez MM, Gago G, Gramajo H, Buschiazzo A Nat Commun. 2020 Jul 24;11(1):3703. doi: 10.1038/s41467-020-17504-x. PMID:32710080<ref>PMID:32710080</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6o6p" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:22, 11 March 2020

OCA — Wed, 11 Mar 2020 07:22:10 GMT

←Older revision		Revision as of 07:22, 11 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6o6p ~~is ON HOLD until Paper Publication~~	+	==Structure of the regulator FasR from Mycobacterium tuberculosis in complex with DNA==
-		+	<StructureSection load='6o6p' size='340' side='right'caption='[[6o6p]], [[Resolution\|resolution]] 3.85Å' scene=''>
-	~~Authors~~: ~~Larrieux~~, N., ~~Trajtenberg, F~~., ~~Lara, J~~., ~~Gramajo, H~~., Buschiazzo, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6o6p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O6P FirstGlance]. <br>
-	~~Description~~: ~~Structure of the regulator FasR from Mycobacterium tuberculosis in complex with DNA~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6p OCA], [http://pdbe.org/6o6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6p RCSB], [http://www.ebi.ac.uk/pdbsum/6o6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6p ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Buschiazzo, A]]
		+	[[Category: Gramajo, H]]
		+	[[Category: Lara, J]]
	[[Category: Larrieux, N]]		[[Category: Larrieux, N]]
-	[[Category: Lara, J]]
-	[[Category: Gramajo, H]]
-	[[Category: Buschiazzo, A]]
	[[Category: Trajtenberg, F]]		[[Category: Trajtenberg, F]]
		+	[[Category: Fatty acid biosynthesis regulation]]
		+	[[Category: Tetr-like transcription factor]]
		+	[[Category: Transcription-dna complex]]

OCA at 04:34, 3 April 2019

OCA — Wed, 03 Apr 2019 04:34:11 GMT

←Older revision		Revision as of 04:34, 3 April 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6o6p is ON HOLD	+	The entry 6o6p is ON HOLD until Paper Publication

	Authors: Larrieux, N., Trajtenberg, F., Lara, J., Gramajo, H., Buschiazzo, A.		Authors: Larrieux, N., Trajtenberg, F., Lara, J., Gramajo, H., Buschiazzo, A.

OCA: Protected "6o6p" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2019 10:17:44 GMT

Protected "6o6p" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:17, 13 March 2019

OCA: New page: '''Unreleased structure''' The entry 6o6p is ON HOLD Authors: Larrieux, N., Trajtenberg, F., Lara, J., Gramajo, H., Buschiazzo, A. Description: Structure of the regulator FasR from Myc...

OCA — Wed, 13 Mar 2019 10:17:43 GMT

New page: '''Unreleased structure''' The entry 6o6p is ON HOLD Authors: Larrieux, N., Trajtenberg, F., Lara, J., Gramajo, H., Buschiazzo, A. Description: Structure of the regulator FasR from Myc...

New page

'''Unreleased structure'''

The entry 6o6p is ON HOLD

Authors: Larrieux, N., Trajtenberg, F., Lara, J., Gramajo, H., Buschiazzo, A.

Description: Structure of the regulator FasR from Mycobacterium tuberculosis in complex with DNA
[[Category: Unreleased Structures]]
[[Category: Larrieux, N]]
[[Category: Lara, J]]
[[Category: Gramajo, H]]
[[Category: Buschiazzo, A]]
[[Category: Trajtenberg, F]]