6o6w - Revision history

OCA at 10:56, 14 June 2023

OCA — Wed, 14 Jun 2023 10:56:19 GMT

←Older revision		Revision as of 10:56, 14 June 2023
Line 1:		Line 1:

	==Solution structure of human myeloid-derived growth factor==		==Solution structure of human myeloid-derived growth factor==
-	<StructureSection load='6o6w' size='340' side='right'caption='[[6o6w~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6o6w' size='340' side='right'caption='[[6o6w]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o6w]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6O6W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o6w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O6W FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYDGF, C19orf10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6w OCA], [https://pdbe.org/6o6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o6w RCSB], [https://www.ebi.ac.uk/pdbsum/6o6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6w ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6o6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6w OCA], [~~http~~://pdbe.org/6o6w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o6w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o6w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6w ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN]] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref>	+	[https://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bortnov, V]]	+	[[Category: Bortnov V]]
-	[[Category: Lee, W]]	+	[[Category: Lee W]]
-	[[Category: Markley~~, J L~~]]	+	[[Category: Markley JL]]
-	[[Category: Mosher~~, D F~~]]	+	[[Category: Mosher DF]]
-	[[Category: Tonelli, M]]	+	[[Category: Tonelli M]]
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Unknown function]]~~	+
-	~~[[Category: Upf0556~~]]	+

OCA at 13:05, 25 December 2019

OCA — Wed, 25 Dec 2019 13:05:27 GMT

←Older revision		Revision as of 13:05, 25 December 2019
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN]] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref>		[[http://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN]] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human myeloid-derived growth factor (hMYDGF) is a 142-residue protein with a C-terminal endoplasmic reticulum (ER) retention sequence (ERS). Extracellular MYDGF mediates cardiac repair in mice after anoxic injury. Although homologs of hMYDGF are found in eukaryotes as distant as protozoans, its structure and function are unknown. Here we present the NMR solution structure of hMYDGF, which consists of a short alpha-helix and ten beta-strands distributed in three beta-sheets. Conserved residues map to the unstructured ERS, loops on the face opposite the ERS, and the surface of a cavity underneath the conserved loops. The only protein or portion of a protein known to have a similar fold is the base domain of VNN1. We suggest, in analogy to the tethering of the VNN1 nitrilase domain to the plasma membrane via its base domain, that MYDGF complexed to the KDEL receptor binds cargo via its conserved residues for transport to the ER.
		+
		+	Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum.,Bortnov V, Tonelli M, Lee W, Lin Z, Annis DS, Demerdash ON, Bateman A, Mitchell JC, Ge Y, Markley JL, Mosher DF Nat Commun. 2019 Dec 9;10(1):5612. doi: 10.1038/s41467-019-13577-5. PMID:31819058<ref>PMID:31819058</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6o6w" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:53, 18 December 2019

OCA — Wed, 18 Dec 2019 11:53:13 GMT

←Older revision		Revision as of 11:53, 18 December 2019
Line 3:		Line 3:
	<StructureSection load='6o6w' size='340' side='right'caption='[[6o6w]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6o6w' size='340' side='right'caption='[[6o6w]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o6w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O6W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o6w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O6W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6w OCA], [http://pdbe.org/6o6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6w RCSB], [http://www.ebi.ac.uk/pdbsum/6o6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6w ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYDGF, C19orf10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6w OCA], [http://pdbe.org/6o6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6w RCSB], [http://www.ebi.ac.uk/pdbsum/6o6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bortnov, V]]		[[Category: Bortnov, V]]

OCA at 11:05, 13 November 2019

OCA — Wed, 13 Nov 2019 11:05:44 GMT

←Older revision		Revision as of 11:05, 13 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6o6w is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Solution structure of human myeloid-derived growth factor==
-		+	<StructureSection load='6o6w' size='340' side='right'caption='[[6o6w]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6o6w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O6W FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o6w OCA], [http://pdbe.org/6o6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o6w RCSB], [http://www.ebi.ac.uk/pdbsum/6o6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o6w ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN]] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bortnov, V]]
		+	[[Category: Lee, W]]
		+	[[Category: Markley, J L]]
		+	[[Category: Mosher, D F]]
		+	[[Category: Tonelli, M]]
		+	[[Category: Endoplasmic reticulum]]
		+	[[Category: Unknown function]]
		+	[[Category: Upf0556]]

OCA at 04:08, 21 August 2019

OCA — Wed, 21 Aug 2019 04:08:52 GMT

←Older revision		Revision as of 04:08, 21 August 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6o6w is ON HOLD	+	The entry 6o6w is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6o6w" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2019 10:18:09 GMT

Protected "6o6w" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:18, 13 March 2019

OCA: New page: '''Unreleased structure''' The entry 6o6w is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Mar 2019 10:18:08 GMT

New page: '''Unreleased structure''' The entry 6o6w is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6o6w is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]