6o8l - Revision history

OCA at 07:06, 11 October 2023

OCA — Wed, 11 Oct 2023 07:06:03 GMT

←Older revision		Revision as of 07:06, 11 October 2023
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	<StructureSection load='6o8l' size='340' side='right'caption='[[6o8l]], [[Resolution\|resolution]] 1.36Å' scene=''>		<StructureSection load='6o8l' size='340' side='right'caption='[[6o8l]], [[Resolution\|resolution]] 1.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o8l]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"rhodonostoc_capsulatum"_molisch_1907 "rhodonostoc capsulatum" molisch 1907~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6O8L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o8l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O8L FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6o8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8l OCA], [~~http~~://pdbe.org/6o8l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o8l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o8l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8l ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.36Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8l OCA], [https://pdbe.org/6o8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o8l RCSB], [https://www.ebi.ac.uk/pdbsum/6o8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8l ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D5AT91_RHOCB D5AT91_RHOCB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Rhodonostoc capsulatum molisch 1907]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Capdevila, D A~~]]	+	[[Category: Rhodobacter capsulatus]]
-	[[Category: ~~Giedroc, D P~~]]	+	[[Category: Capdevila DA]]
-	[[Category: ~~Gonzalez-Gutierrez, G~~]]	+	[[Category: Giedroc DP]]
-	[[Category: ~~Photosynthesis regulation]]~~	+	[[Category: Gonzalez-Gutierrez G]]
-	~~[[Category: Reactive sulfur species]]~~	+
-	~~[[Category: Sulfide sensor]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor~~]]	+

OCA at 08:07, 11 November 2020

OCA — Wed, 11 Nov 2020 08:07:07 GMT

←Older revision		Revision as of 08:07, 11 November 2020
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8l OCA], [http://pdbe.org/6o8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o8l RCSB], [http://www.ebi.ac.uk/pdbsum/6o8l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8l ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8l OCA], [http://pdbe.org/6o8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o8l RCSB], [http://www.ebi.ac.uk/pdbsum/6o8l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8l ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cysteine thiol-based transcriptional regulators orchestrate the coordinated regulation of redox homeostasis and other cellular processes by 'sensing' or detecting a specific redox-active molecule, which in turn activates the transcription of a specific detoxification pathway. The extent to which these sensors are truly specific in cells for a singular class of reactive small-molecule stressors, for example, reactive oxygen or sulfur species, is largely unknown. Here, we report structural and mechanistic insights into the thiol-based transcriptional repressor SqrR, which reacts exclusively with oxidized sulfur species such as persulfides, to yield a tetrasulfide bridge that inhibits DNA operator-promoter binding. Evaluation of crystallographic structures of SqrR in various derivatized states, coupled with the results of a mass spectrometry-based kinetic profiling strategy, suggest that persulfide selectivity is determined by structural frustration of the disulfide form. These findings led to the identification of an uncharacterized repressor from the bacterial pathogen Acinetobacter baumannii as a persulfide sensor.
		+
		+	Structural basis for persulfide-sensing specificity in a transcriptional regulator.,Capdevila DA, Walsh BJC, Zhang Y, Dietrich C, Gonzalez-Gutierrez G, Giedroc DP Nat Chem Biol. 2020 Oct 26. pii: 10.1038/s41589-020-00671-9. doi:, 10.1038/s41589-020-00671-9. PMID:33106663<ref>PMID:33106663</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6o8l" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:43, 28 October 2020

OCA — Wed, 28 Oct 2020 20:43:27 GMT

←Older revision		Revision as of 20:43, 28 October 2020
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	<StructureSection load='6o8l' size='340' side='right'caption='[[6o8l]], [[Resolution\|resolution]] 1.36Å' scene=''>		<StructureSection load='6o8l' size='340' side='right'caption='[[6o8l]], [[Resolution\|resolution]] 1.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o8l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8L OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6O8L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o8l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"rhodonostoc_capsulatum"_molisch_1907 "rhodonostoc capsulatum" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6O8L FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6o8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8l OCA], [http://pdbe.org/6o8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o8l RCSB], [http://www.ebi.ac.uk/pdbsum/6o8l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8l ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8l OCA], [http://pdbe.org/6o8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o8l RCSB], [http://www.ebi.ac.uk/pdbsum/6o8l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8l ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Rhodonostoc capsulatum molisch 1907]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Capdevila, D A]]		[[Category: Capdevila, D A]]

OCA at 09:11, 1 April 2020

OCA — Wed, 01 Apr 2020 09:11:06 GMT

←Older revision		Revision as of 09:11, 1 April 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6o8l is ON HOLD until Paper Publication~~	+	==Crystal Structure of C9S apo and reduced Sulfide-responsive transcriptional repressor (SqrR) from Rhodobacter capsulatus.==
-		+	<StructureSection load='6o8l' size='340' side='right'caption='[[6o8l]], [[Resolution\|resolution]] 1.36Å' scene=''>
-	~~Authors: Capdevila, D.A., Gonzalez-Gutierrez, G., Giedroc, D.P.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6o8l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O8L FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of C9S apo and reduced Sulfide-responsive transcriptional repressor (SqrR) from Rhodobacter capsulatus.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8l OCA], [http://pdbe.org/6o8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o8l RCSB], [http://www.ebi.ac.uk/pdbsum/6o8l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8l ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Giedroc~~, D.P]]	+	__TOC__
-	[[Category: ~~Capdevila~~, D.A]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Capdevila, D A]]
		+	[[Category: Giedroc, D P]]
	[[Category: Gonzalez-Gutierrez, G]]		[[Category: Gonzalez-Gutierrez, G]]
		+	[[Category: Photosynthesis regulation]]
		+	[[Category: Reactive sulfur species]]
		+	[[Category: Sulfide sensor]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription factor]]

OCA at 04:36, 3 April 2019

OCA — Wed, 03 Apr 2019 04:36:18 GMT

←Older revision		Revision as of 04:36, 3 April 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6o8l is ON HOLD	+	The entry 6o8l is ON HOLD until Paper Publication

	Authors: Capdevila, D.A., Gonzalez-Gutierrez, G., Giedroc, D.P.		Authors: Capdevila, D.A., Gonzalez-Gutierrez, G., Giedroc, D.P.

OCA: Protected "6o8l" [edit=sysop:move=sysop]

OCA — Wed, 20 Mar 2019 05:59:47 GMT

Protected "6o8l" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:59, 20 March 2019

OCA: New page: '''Unreleased structure''' The entry 6o8l is ON HOLD Authors: Capdevila, D.A., Gonzalez-Gutierrez, G., Giedroc, D.P. Description: Crystal Structure of C9S apo and reduced Sulfide-respo...

OCA — Wed, 20 Mar 2019 05:59:46 GMT

New page: '''Unreleased structure''' The entry 6o8l is ON HOLD Authors: Capdevila, D.A., Gonzalez-Gutierrez, G., Giedroc, D.P. Description: Crystal Structure of C9S apo and reduced Sulfide-respo...

New page

'''Unreleased structure'''

The entry 6o8l is ON HOLD

Authors: Capdevila, D.A., Gonzalez-Gutierrez, G., Giedroc, D.P.

Description: Crystal Structure of C9S apo and reduced Sulfide-responsive transcriptional repressor (SqrR) from Rhodobacter capsulatus.
[[Category: Unreleased Structures]]
[[Category: Giedroc, D.P]]
[[Category: Capdevila, D.A]]
[[Category: Gonzalez-Gutierrez, G]]