6o8r - Revision history

OCA at 10:56, 14 June 2023

OCA — Wed, 14 Jun 2023 10:56:26 GMT

←Older revision		Revision as of 10:56, 14 June 2023
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	==Syn-safencin 24==		==Syn-safencin 24==
-	<StructureSection load='6o8r' size='340' side='right'caption='[[6o8r~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='6o8r' size='340' side='right'caption='[[6o8r]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o8r]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6O8R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o8r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_safensis Bacillus safensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O8R FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6o8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8r OCA], [~~http~~://pdbe.org/6o8r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o8r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o8r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8r ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8r OCA], [https://pdbe.org/6o8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o8r RCSB], [https://www.ebi.ac.uk/pdbsum/6o8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8r ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus safensis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fields~~, F R~~]]	+	[[Category: Fields FR]]
-	[[Category: Lee~~, S W]]~~	+	[[Category: Lee SW]]
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Synthetic peptide~~]]	+

OCA at 14:33, 8 July 2020

OCA — Wed, 08 Jul 2020 14:33:21 GMT

←Older revision		Revision as of 14:33, 8 July 2020
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	==Syn-safencin 24==		==Syn-safencin 24==
-	<StructureSection load='6o8r' size='340' side='right'caption='[[6o8r]]' scene=''>	+	<StructureSection load='6o8r' size='340' side='right'caption='[[6o8r]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6O8R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o8r]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6O8R FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8r OCA], [http://pdbe.org/6o8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o8r RCSB], [http://www.ebi.ac.uk/pdbsum/6o8r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8r ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8r OCA], [http://pdbe.org/6o8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o8r RCSB], [http://www.ebi.ac.uk/pdbsum/6o8r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8r ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ribosomally produced antimicrobial peptides of bacteria (bacteriocins) represent an unexplored source of membrane-active antibiotics. We designed a library of linear peptides from a circular bacteriocin and show that pore-formation dynamics in bacterial membranes are tunable via selective amino acid substitution. We observed antibacterial interpeptide synergy indicating that fundamentally altering interactions with the membrane enables synergy. Our findings suggest an approach for engineering pore-formation through rational peptide design and increasing the utility of novel antimicrobial peptides by exploiting synergy.
		+
		+	Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy.,Fields FR, Manzo G, Hind CK, Janardhanan J, Foik IP, Carmo Silva PD, Balsara RD, Clifford M, Vu HM, Ross JN, Kalwajtys VR, Gonzalez AJ, Bui TT, Ploplis VA, Castellino FJ, Siryaporn A, Chang M, Sutton JM, Mason AJ, Lee S ACS Pharmacol Transl Sci. 2020 Feb 21;3(3):418-424. doi:, 10.1021/acsptsci.0c00001. eCollection 2020 Jun 12. PMID:32566907<ref>PMID:32566907</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6o8r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fields FR]]	+	[[Category: Fields, F R]]
-	[[Category: Lee SW]]	+	[[Category: Lee, S W]]
		+	[[Category: Antimicrobial]]
		+	[[Category: Antimicrobial protein]]
		+	[[Category: Synthetic peptide]]

OCA at 05:26, 13 May 2020

OCA — Wed, 13 May 2020 05:26:52 GMT

←Older revision		Revision as of 05:26, 13 May 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6o8r is ~~ON HOLD until sometime in~~ the ~~future~~	+	==Syn-safencin 24==
-		+	<StructureSection load='6o8r' size='340' side='right'caption='[[6o8r]]' scene=''>
-	~~Authors~~: ~~Fields~~, F.R., ~~Lee~~, S.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6O8R FirstGlance]. <br>
-	~~Description~~: ~~Syn~~-~~safencin 24~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8r OCA], [http://pdbe.org/6o8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o8r RCSB], [http://www.ebi.ac.uk/pdbsum/6o8r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8r ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Lee, S.W~~]]	+	__TOC__
-	[[Category: ~~Fields, F.R~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fields FR]]
		+	[[Category: Lee SW]]

OCA at 13:33, 20 November 2019

OCA — Wed, 20 Nov 2019 13:33:31 GMT

←Older revision		Revision as of 13:33, 20 November 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6o8r is ON HOLD	+	The entry 6o8r is ON HOLD until sometime in the future

	Authors: Fields, F.R., Lee, S.W.		Authors: Fields, F.R., Lee, S.W.

OCA: Protected "6o8r" [edit=sysop:move=sysop]

OCA — Wed, 20 Mar 2019 06:00:09 GMT

Protected "6o8r" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 20 March 2019

OCA: New page: '''Unreleased structure''' The entry 6o8r is ON HOLD Authors: Fields, F.R., Lee, S.W. Description: Syn-safencin 24 Category: Unreleased Structures Category: Lee, S.W [[Category...

OCA — Wed, 20 Mar 2019 06:00:07 GMT

New page: '''Unreleased structure''' The entry 6o8r is ON HOLD Authors: Fields, F.R., Lee, S.W. Description: Syn-safencin 24 Category: Unreleased Structures Category: Lee, S.W [[Category...

New page

'''Unreleased structure'''

The entry 6o8r is ON HOLD

Authors: Fields, F.R., Lee, S.W.

Description: Syn-safencin 24
[[Category: Unreleased Structures]]
[[Category: Lee, S.W]]
[[Category: Fields, F.R]]