6oaw - Revision history

OCA at 07:39, 23 May 2019

OCA — Thu, 23 May 2019 07:39:32 GMT

←Older revision		Revision as of 07:39, 23 May 2019
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	<StructureSection load='6oaw' size='340' side='right'caption='[[6oaw]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6oaw' size='340' side='right'caption='[[6oaw]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6oaw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6oaw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ruminococcus_sp. Ruminococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OAW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCZ53_08630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41978 Ruminococcus sp.])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oaw OCA], [http://pdbe.org/6oaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oaw RCSB], [http://www.ebi.ac.uk/pdbsum/6oaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oaw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oaw OCA], [http://pdbe.org/6oaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oaw RCSB], [http://www.ebi.ac.uk/pdbsum/6oaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oaw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Type VI-D CRISPR-Cas system employs an RNA-guided RNase Cas13d with minimal targeting constraints to combat viral infections. This CRISPR system contains RspWYL1 as a unique accessory protein that plays a key role in boosting its effector function on target RNAs, but the mechanism behind this RspWYL1-mediated stimulation remains completely unexplored. Through structural and biophysical approaches, we reveal that the full-length RspWYL1 possesses a novel three-domain architecture and preferentially binds ssRNA with high affinity. Specifically, the N-terminus of RspWYL1 harbors a ribbon-helix-helix motif reminiscent of transcriptional regulators; the central WYL domain of RspWYL1 displays a Sm-like beta-barrel fold; and the C-terminal domain of RspWYL1 primarily contributes to the dimerization of RspWYL1 and may regulate the RspWYL1 function via a large conformational change. Collectively, this study provides a first glimpse into the complex mechanism behind the RspWYL1-dictated boosting of target ssRNA cleavage in the Type VI-D CRISPR-Cas system.
		+
		+	Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system.,Zhang H, Dong C, Li L, Wasney GA, Min J Nucleic Acids Res. 2019 Apr 12. pii: 5446253. doi: 10.1093/nar/gkz269. PMID:30976796<ref>PMID:30976796</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6oaw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Ruminococcus sp]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 07:29, 10 April 2019

OCA — Wed, 10 Apr 2019 07:29:11 GMT

←Older revision		Revision as of 07:29, 10 April 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6oaw ~~is ON HOLD~~	+	==Crystal structure of a CRISPR Cas-related protein==
-		+	<StructureSection load='6oaw' size='340' side='right'caption='[[6oaw]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6oaw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OAW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oaw OCA], [http://pdbe.org/6oaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oaw RCSB], [http://www.ebi.ac.uk/pdbsum/6oaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oaw ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Structural genomic]]
		+	[[Category: Dong, C]]
		+	[[Category: Edwards, A M]]
		+	[[Category: Li, L]]
		+	[[Category: Min, J]]
		+	[[Category: Tempel, W]]
		+	[[Category: Zhang, H]]
		+	[[Category: Immune system]]
		+	[[Category: Sgc]]
		+	[[Category: Wyl domain]]

OCA: Protected "6oaw" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2019 05:04:23 GMT

Protected "6oaw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:04, 27 March 2019

OCA: New page: '''Unreleased structure''' The entry 6oaw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Mar 2019 05:04:22 GMT

New page: '''Unreleased structure''' The entry 6oaw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6oaw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]