6odd - Revision history

OCA at 07:08, 11 October 2023

OCA — Wed, 11 Oct 2023 07:08:36 GMT

←Older revision		Revision as of 07:08, 11 October 2023
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	<StructureSection load='6odd' size='340' side='right'caption='[[6odd]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6odd' size='340' side='right'caption='[[6odd]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6odd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ODD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6odd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ODD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Q1:S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]+dodecanethioate'>8Q1</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDUFAB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LYRM4, C6orf149, ISD11, CGI-203 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8Q1:S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]+dodecanethioate'>8Q1</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odd OCA], [~~http~~://pdbe.org/6odd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6odd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6odd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6odd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odd OCA], [https://pdbe.org/6odd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6odd RCSB], [https://www.ebi.ac.uk/pdbsum/6odd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6odd ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/LYRM4_HUMAN LYRM4_HUMAN]] Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ACPM_HUMAN ACPM_HUMAN]] Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity). ~~[[http://www.uniprot.org/uniprot/LYRM4_HUMAN LYRM4_HUMAN]] Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.<ref>PMID:17331979</ref> <ref>PMID:19454487</ref>~~	+	[https://www.uniprot.org/uniprot/ACPM_HUMAN ACPM_HUMAN] Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6odd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6odd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acyl carrier protein 3D structures\|Acyl carrier protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Herrera~~, M G~~]]	+	[[Category: Herrera MG]]
-	[[Category: Klinke, S]]	+	[[Category: Klinke S]]
-	[[Category: Noguera~~, M E~~]]	+	[[Category: Noguera ME]]
-	[[Category: Santos, J]]	+	[[Category: Santos J]]
-	~~[[Category: Biosynthetic protein]]~~	+
-	~~[[Category: Cysteine desulfurase activity regulator]]~~	+
-	~~[[Category: Iron sulfur cluster~~]]	+

OCA at 10:40, 4 December 2019

OCA — Wed, 04 Dec 2019 10:40:19 GMT

←Older revision		Revision as of 10:40, 4 December 2019
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	<StructureSection load='6odd' size='340' side='right'caption='[[6odd]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6odd' size='340' side='right'caption='[[6odd]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6odd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ODD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6odd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ODD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Q1:S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]+dodecanethioate'>8Q1</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Q1:S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]+dodecanethioate'>8Q1</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDUFAB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LYRM4, C6orf149, ISD11, CGI-203 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odd OCA], [http://pdbe.org/6odd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6odd RCSB], [http://www.ebi.ac.uk/pdbsum/6odd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6odd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odd OCA], [http://pdbe.org/6odd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6odd RCSB], [http://www.ebi.ac.uk/pdbsum/6odd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6odd ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Herrera, M G]]		[[Category: Herrera, M G]]

OCA at 06:50, 27 November 2019

OCA — Wed, 27 Nov 2019 06:50:57 GMT

←Older revision		Revision as of 06:50, 27 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6odd is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of the human complex ACP-ISD11==
		+	<StructureSection load='6odd' size='340' side='right'caption='[[6odd]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6odd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ODD FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Q1:S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]+dodecanethioate'>8Q1</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odd OCA], [http://pdbe.org/6odd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6odd RCSB], [http://www.ebi.ac.uk/pdbsum/6odd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6odd ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/LYRM4_HUMAN LYRM4_HUMAN]] Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACPM_HUMAN ACPM_HUMAN]] Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity). [[http://www.uniprot.org/uniprot/LYRM4_HUMAN LYRM4_HUMAN]] Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.<ref>PMID:17331979</ref> <ref>PMID:19454487</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In recent years, the mammalian mitochondrial protein complex for iron-sulfur cluster assembly has been the focus of important studies. This is partly because of its high degree of relevance in cell metabolism and because mutations of the involved proteins are the cause of several human diseases. Cysteine desulfurase NFS1 is the key enzyme of the complex. At present, it is well-known that the active form of NFS1 is stabilized by the small protein ISD11. In this work, the structure of the human mitochondrial ACP-ISD11 heterodimer was determined at 2.0 A resolution. ACP-ISD11 forms a cooperative unit stabilized by several ionic interactions, hydrogen bonds, and apolar interactions. The 4'-phosphopantetheine-acyl chain, which is covalently bound to ACP, interacts with several residues of ISD11, modulating together with ACP the foldability of ISD11. Recombinant human ACP-ISD11 was able to interact with the NFS1 desulfurase, thus yielding an active enzyme, and the NFS1/ACP-ISD11 core complex was activated by frataxin and ISCU proteins. Internal motions of ACP-ISD11 were studied by molecular dynamics simulations, showing the persistence of the interactions between both protein chains. The conformation of the dimer is similar to that found in the context of the (NFS1/ACP-ISD11)2 supercomplex core, which contains the Escherichia coli ACP instead of the human variant. This fact suggests a sequential mechanism for supercomplex consolidation, in which the ACP-ISD11 complex may fold independently and, after that, the NFS1 dimer would be stabilized.

-	~~Authors: Herrera, M.G~~., Noguera, ~~M.E.~~, ~~Klinke~~, S., Santos, J.	+	Structure of the Human ACP-ISD11 Heterodimer.,Herrera MG, Noguera ME, Sewell KE, Agudelo Suarez WA, Capece L, Klinke S, Santos J Biochemistry. 2019 Nov 19;58(46):4596-4609. doi: 10.1021/acs.biochem.9b00539., Epub 2019 Nov 8. PMID:31664822<ref>PMID:31664822</ref>

-	~~Description: Crystal structure~~ of the ~~human complex ACP~~-~~ISD11~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Noguera~~, M~~.E]]~~	+	<div class="pdbe-citations 6odd" style="background-color:#fffaf0;"></div>
-	~~[[Category: Santos, J~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Herrera, M G]]
	[[Category: Klinke, S]]		[[Category: Klinke, S]]
-	[[Category: ~~Herrera~~, M.G]]	+	[[Category: Noguera, M E]]
		+	[[Category: Santos, J]]
		+	[[Category: Biosynthetic protein]]
		+	[[Category: Cysteine desulfurase activity regulator]]
		+	[[Category: Iron sulfur cluster]]

OCA at 04:07, 17 April 2019

OCA — Wed, 17 Apr 2019 04:07:27 GMT

←Older revision		Revision as of 04:07, 17 April 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6odd is ON HOLD	+	The entry 6odd is ON HOLD until Paper Publication

	Authors: Herrera, M.G., Noguera, M.E., Klinke, S., Santos, J.		Authors: Herrera, M.G., Noguera, M.E., Klinke, S., Santos, J.

OCA: Protected "6odd" [edit=sysop:move=sysop]

OCA — Wed, 03 Apr 2019 04:43:51 GMT

Protected "6odd" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:43, 3 April 2019

OCA: New page: '''Unreleased structure''' The entry 6odd is ON HOLD Authors: Herrera, M.G., Noguera, M.E., Klinke, S., Santos, J. Description: Crystal structure of the human complex ACP-ISD11 [[Categ...

OCA — Wed, 03 Apr 2019 04:43:50 GMT

New page: '''Unreleased structure''' The entry 6odd is ON HOLD Authors: Herrera, M.G., Noguera, M.E., Klinke, S., Santos, J. Description: Crystal structure of the human complex ACP-ISD11 [[Categ...

New page

'''Unreleased structure'''

The entry 6odd is ON HOLD

Authors: Herrera, M.G., Noguera, M.E., Klinke, S., Santos, J.

Description: Crystal structure of the human complex ACP-ISD11
[[Category: Unreleased Structures]]
[[Category: Noguera, M.E]]
[[Category: Santos, J]]
[[Category: Klinke, S]]
[[Category: Herrera, M.G]]