6odi - Revision history

OCA at 09:23, 20 March 2024

OCA — Wed, 20 Mar 2024 09:23:44 GMT

←Older revision		Revision as of 09:23, 20 March 2024
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	<SX load='6odi' size='340' side='right' viewer='molstar' caption='[[6odi]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6odi' size='340' side='right' viewer='molstar' caption='[[6odi]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6odi]] is a 14 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ODI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6odi]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ODI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6odi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odi OCA], [~~http~~://pdbe.org/6odi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6odi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6odi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6odi ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6odi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odi OCA], [https://pdbe.org/6odi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6odi RCSB], [https://www.ebi.ac.uk/pdbsum/6odi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6odi ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/O25262_HELPY O25262_HELPY]
-	Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS complex, which contains three sub-complexes: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and stalk domain. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system complexes ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.	+
-		+
-	Structure of the Helicobacter pylori Cag Type IV secretion system.,Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD Elife. 2019 Jun 18;8. pii: 47644. doi: 10.7554/~~eLife.47644. PMID:31210639<ref>PMID:31210639<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6odi" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Campbell, A]]	+	[[Category: Campbell A]]
-	[[Category: Chung~~, J M~~]]	+	[[Category: Chung JM]]
-	[[Category: Cover~~, T L~~]]	+	[[Category: Cover TL]]
-	[[Category: Frick-Cheng~~, A E~~]]	+	[[Category: Frick-Cheng AE]]
-	[[Category: Lacy~~, D B~~]]	+	[[Category: Lacy DB]]
-	[[Category: Ohi~~, M D~~]]	+	[[Category: Ohi MD]]
-	[[Category: Sawhney, N]]	+	[[Category: Sawhney N]]
-	[[Category: Sheedlo~~, M J]]~~	+	[[Category: Sheedlo MJ]]
-	~~[[Category: H. pylori]]~~	+
-	~~[[Category: Secretion]]~~	+
-	~~[[Category: T4ss]]~~	+
-	~~[[Category: Translocase~~]]	+

OCA at 03:51, 11 April 2020

OCA — Sat, 11 Apr 2020 03:51:51 GMT

←Older revision		Revision as of 03:51, 11 April 2020
Line 3:		Line 3:
	<SX load='6odi' size='340' side='right' viewer='molstar' caption='[[6odi]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6odi' size='340' side='right' viewer='molstar' caption='[[6odi]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6odi]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ODI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6odi]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ODI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6odi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odi OCA], [http://pdbe.org/6odi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6odi RCSB], [http://www.ebi.ac.uk/pdbsum/6odi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6odi ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6odi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odi OCA], [http://pdbe.org/6odi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6odi RCSB], [http://www.ebi.ac.uk/pdbsum/6odi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6odi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:09, 6 March 2020

OCA — Fri, 06 Mar 2020 23:09:44 GMT

←Older revision		Revision as of 23:09, 6 March 2020
Line 1:		Line 1:

	==Structure of CagY from a cryo-EM reconstruction of a T4SS==		==Structure of CagY from a cryo-EM reconstruction of a T4SS==
-	<~~StructureSection~~ load='6odi' size='340' side='right'caption='[[6odi]], [[Resolution\|resolution]] 3.80Å' scene=''>	+	<SX load='6odi' size='340' side='right' viewer='molstar' caption='[[6odi]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6odi]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ODI FirstGlance]. <br>		<table><tr><td colspan='2'>[[6odi]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ODI FirstGlance]. <br>
Line 18:		Line 18:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 05:57, 3 July 2019

OCA — Wed, 03 Jul 2019 05:57:54 GMT

←Older revision		Revision as of 05:57, 3 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6odi is ~~ON HOLD~~	+	==Structure of CagY from a cryo-EM reconstruction of a T4SS==
		+	<StructureSection load='6odi' size='340' side='right'caption='[[6odi]], [[Resolution\|resolution]] 3.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6odi]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ODI FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6odi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odi OCA], [http://pdbe.org/6odi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6odi RCSB], [http://www.ebi.ac.uk/pdbsum/6odi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6odi ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS complex, which contains three sub-complexes: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and stalk domain. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system complexes ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.

-	~~Authors~~:	+	Structure of the Helicobacter pylori Cag Type IV secretion system.,Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD Elife. 2019 Jun 18;8. pii: 47644. doi: 10.7554/eLife.47644. PMID:31210639<ref>PMID:31210639</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6odi" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Large Structures]]
		+	[[Category: Campbell, A]]
		+	[[Category: Chung, J M]]
		+	[[Category: Cover, T L]]
		+	[[Category: Frick-Cheng, A E]]
		+	[[Category: Lacy, D B]]
		+	[[Category: Ohi, M D]]
		+	[[Category: Sawhney, N]]
		+	[[Category: Sheedlo, M J]]
		+	[[Category: H. pylori]]
		+	[[Category: Secretion]]
		+	[[Category: T4ss]]
		+	[[Category: Translocase]]

OCA: Protected "6odi" [edit=sysop:move=sysop]

OCA — Wed, 03 Apr 2019 04:44:24 GMT

Protected "6odi" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:44, 3 April 2019

OCA: New page: '''Unreleased structure''' The entry 6odi is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Apr 2019 04:44:22 GMT

New page: '''Unreleased structure''' The entry 6odi is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6odi is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]