6oeg - Revision history

OCA at 14:51, 13 March 2024

OCA — Wed, 13 Mar 2024 14:51:44 GMT

←Older revision		Revision as of 14:51, 13 March 2024
Line 3:		Line 3:
	<SX load='6oeg' size='340' side='right' viewer='molstar' caption='[[6oeg]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6oeg' size='340' side='right' viewer='molstar' caption='[[6oeg]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6oeg]] is a 14 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6OEG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6oeg]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OEG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6oeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oeg OCA], [~~http~~://pdbe.org/6oeg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6oeg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6oeg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6oeg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oeg OCA], [https://pdbe.org/6oeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oeg RCSB], [https://www.ebi.ac.uk/pdbsum/6oeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oeg ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/A0A2J9KJM4_HELPX A0A2J9KJM4_HELPX]
-	Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS complex, which contains three sub-complexes: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and stalk domain. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system complexes ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.	+
-		+
-	Structure of the Helicobacter pylori Cag Type IV secretion system.,Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD Elife. 2019 Jun 18;8. pii: 47644. doi: 10.7554/~~eLife.47644. PMID:31210639<ref>PMID:31210639<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6oeg" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Campbell, A]]	+	[[Category: Campbell A]]
-	[[Category: Chung~~, J M~~]]	+	[[Category: Chung JM]]
-	[[Category: Cover~~, T L~~]]	+	[[Category: Cover TL]]
-	[[Category: Frick-Cheng~~, A E~~]]	+	[[Category: Frick-Cheng AE]]
-	[[Category: Lacy~~, D B~~]]	+	[[Category: Lacy DB]]
-	[[Category: Ohi~~, M D~~]]	+	[[Category: Ohi MD]]
-	[[Category: Sawhney, N]]	+	[[Category: Sawhney N]]
-	[[Category: Sheedlo~~, M J]]~~	+	[[Category: Sheedlo MJ]]
-	~~[[Category: H. pylori]]~~	+
-	~~[[Category: Secretion]]~~	+
-	~~[[Category: T4ss]]~~	+
-	~~[[Category: Translocase~~]]	+

OCA at 03:53, 11 April 2020

OCA — Sat, 11 Apr 2020 03:53:04 GMT

←Older revision		Revision as of 03:53, 11 April 2020
Line 3:		Line 3:
	<SX load='6oeg' size='340' side='right' viewer='molstar' caption='[[6oeg]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6oeg' size='340' side='right' viewer='molstar' caption='[[6oeg]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6oeg]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OEG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6oeg]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OEG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6oeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oeg OCA], [http://pdbe.org/6oeg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oeg RCSB], [http://www.ebi.ac.uk/pdbsum/6oeg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oeg ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6oeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oeg OCA], [http://pdbe.org/6oeg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oeg RCSB], [http://www.ebi.ac.uk/pdbsum/6oeg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oeg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:10, 6 March 2020

OCA — Fri, 06 Mar 2020 23:10:09 GMT

←Older revision		Revision as of 23:10, 6 March 2020
Line 1:		Line 1:

	==Structure of CagX from a cryo-EM reconstruction of a T4SS==		==Structure of CagX from a cryo-EM reconstruction of a T4SS==
-	<~~StructureSection~~ load='6oeg' size='340' side='right'caption='[[6oeg]], [[Resolution\|resolution]] 3.80Å' scene=''>	+	<SX load='6oeg' size='340' side='right' viewer='molstar' caption='[[6oeg]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6oeg]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OEG FirstGlance]. <br>		<table><tr><td colspan='2'>[[6oeg]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OEG FirstGlance]. <br>
Line 18:		Line 18:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 05:58, 3 July 2019

OCA — Wed, 03 Jul 2019 05:58:18 GMT

←Older revision		Revision as of 05:58, 3 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6oeg is ~~ON HOLD~~	+	==Structure of CagX from a cryo-EM reconstruction of a T4SS==
		+	<StructureSection load='6oeg' size='340' side='right'caption='[[6oeg]], [[Resolution\|resolution]] 3.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6oeg]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OEG FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oeg OCA], [http://pdbe.org/6oeg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oeg RCSB], [http://www.ebi.ac.uk/pdbsum/6oeg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oeg ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS complex, which contains three sub-complexes: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and stalk domain. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system complexes ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.

-	~~Authors~~:	+	Structure of the Helicobacter pylori Cag Type IV secretion system.,Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD Elife. 2019 Jun 18;8. pii: 47644. doi: 10.7554/eLife.47644. PMID:31210639<ref>PMID:31210639</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6oeg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Large Structures]]
		+	[[Category: Campbell, A]]
		+	[[Category: Chung, J M]]
		+	[[Category: Cover, T L]]
		+	[[Category: Frick-Cheng, A E]]
		+	[[Category: Lacy, D B]]
		+	[[Category: Ohi, M D]]
		+	[[Category: Sawhney, N]]
		+	[[Category: Sheedlo, M J]]
		+	[[Category: H. pylori]]
		+	[[Category: Secretion]]
		+	[[Category: T4ss]]
		+	[[Category: Translocase]]

OCA: Protected "6oeg" [edit=sysop:move=sysop]

OCA — Wed, 03 Apr 2019 04:46:54 GMT

Protected "6oeg" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:46, 3 April 2019

OCA: New page: '''Unreleased structure''' The entry 6oeg is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Apr 2019 04:46:53 GMT

New page: '''Unreleased structure''' The entry 6oeg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6oeg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]