6okp - Revision history

OCA at 04:02, 11 April 2020

OCA — Sat, 11 Apr 2020 04:02:43 GMT

←Older revision		Revision as of 04:02, 11 April 2020
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	<SX load='6okp' size='340' side='right' viewer='molstar' caption='[[6okp]], [[Resolution\|resolution]] 3.28Å' scene=''>		<SX load='6okp' size='340' side='right' viewer='molstar' caption='[[6okp]], [[Resolution\|resolution]] 3.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6okp]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OKP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OKP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6okp]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OKP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OKP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6okp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6okp OCA], [http://pdbe.org/6okp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6okp RCSB], [http://www.ebi.ac.uk/pdbsum/6okp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6okp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6okp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6okp OCA], [http://pdbe.org/6okp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6okp RCSB], [http://www.ebi.ac.uk/pdbsum/6okp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6okp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:13, 6 March 2020

OCA — Fri, 06 Mar 2020 23:13:42 GMT

←Older revision		Revision as of 23:13, 6 March 2020
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	==B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074==		==B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074==
-	<~~StructureSection~~ load='6okp' size='340' side='right'caption='[[6okp]], [[Resolution\|resolution]] 3.28Å' scene=''>	+	<SX load='6okp' size='340' side='right' viewer='molstar' caption='[[6okp]], [[Resolution\|resolution]] 3.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6okp]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OKP FirstGlance]. <br>		<table><tr><td colspan='2'>[[6okp]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OKP FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 12:03, 18 December 2019

OCA — Wed, 18 Dec 2019 12:03:40 GMT

←Older revision		Revision as of 12:03, 18 December 2019
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	</div>		</div>
	<div class="pdbe-citations 6okp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6okp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gp120 3D structures\|Gp120 3D structures]]
		+	*[[Gp41 3D Structures\|Gp41 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:57, 3 July 2019

OCA — Wed, 03 Jul 2019 06:57:50 GMT

←Older revision		Revision as of 06:57, 3 July 2019
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	<StructureSection load='6okp' size='340' side='right'caption='[[6okp]], [[Resolution\|resolution]] 3.28Å' scene=''>		<StructureSection load='6okp' size='340' side='right'caption='[[6okp]], [[Resolution\|resolution]] 3.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6okp]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OKP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6okp]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OKP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6okp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6okp OCA], [http://pdbe.org/6okp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6okp RCSB], [http://www.ebi.ac.uk/pdbsum/6okp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6okp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6okp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6okp OCA], [http://pdbe.org/6okp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6okp RCSB], [http://www.ebi.ac.uk/pdbsum/6okp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6okp ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Barnes, C O]]		[[Category: Barnes, C O]]

OCA at 22:52, 5 June 2019

OCA — Wed, 05 Jun 2019 22:52:33 GMT

←Older revision		Revision as of 22:52, 5 June 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6okp is ~~ON HOLD until Paper~~ Publication	+	==B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074==
		+	<StructureSection load='6okp' size='340' side='right'caption='[[6okp]], [[Resolution\|resolution]] 3.28Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6okp]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OKP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6okp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6okp OCA], [http://pdbe.org/6okp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6okp RCSB], [http://www.ebi.ac.uk/pdbsum/6okp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6okp ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Broadly neutralizing antibodies (bNAbs) against HIV-1 envelope (Env) inform vaccine design and are potential therapeutic agents. We identified SF12 and related bNAbs with up to 62% neutralization breadth from an HIV-infected donor. SF12 recognized a glycan-dominated epitope on Env's silent face and was potent against clade AE viruses, which are poorly covered by V3-glycan bNAbs. A 3.3A cryo-EM structure of a SF12-Env trimer complex showed additional contacts to Env protein residues by SF12 compared with VRC-PG05, the only other known donor-derived silentface antibody, explaining SF12's increased neutralization breadth, potency, and resistance to Env mutation routes. Asymmetric binding of SF12 was associated with distinct N-glycan conformations across Env protomers, demonstrating intra-Env glycan heterogeneity. Administrating SF12 to HIV-1-infected humanized mice suppressed viremia and selected for viruses lacking the N448gp120 glycan. Effective bNAbs can therefore be raised against HIV-1 Env's silent face, suggesting their potential for HIV-1 prevention, therapy, and vaccine development.

-	~~Authors:~~ Barnes, ~~C.O.~~, ~~Bjorkman~~, P.J.	+	Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.,Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP Jr, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ Immunity. 2019 May 14. pii: S1074-7613(19)30194-3. doi:, 10.1016/j.immuni.2019.04.014. PMID:31126879<ref>PMID:31126879</ref>

-	~~Description: B41 SOSIP.664 in complex with~~ the ~~silent~~-~~face antibody SF12 and V3-targeting antibody 10~~-~~1074~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Barnes, C.O]]	+	<div class="pdbe-citations 6okp" style="background-color:#fffaf0;"></div>
-	[[Category: Bjorkman, P.J]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Barnes, C O]]
		+	[[Category: Bjorkman, P J]]
		+	[[Category: Env trimer structure]]
		+	[[Category: Hiv-1 broadly-neutralizing antibody]]
		+	[[Category: Silent face]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 07:50, 10 May 2019

OCA — Fri, 10 May 2019 07:50:52 GMT

←Older revision		Revision as of 07:50, 10 May 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6okp is ON HOLD	+	The entry 6okp is ON HOLD until Paper Publication

	Authors: Barnes, C.O., Bjorkman, P.J.		Authors: Barnes, C.O., Bjorkman, P.J.

OCA: Protected "6okp" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2019 05:00:06 GMT

Protected "6okp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:00, 24 April 2019

OCA: New page: '''Unreleased structure''' The entry 6okp is ON HOLD Authors: Barnes, C.O., Bjorkman, P.J. Description: B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting ant...

OCA — Wed, 24 Apr 2019 05:00:04 GMT

New page: '''Unreleased structure''' The entry 6okp is ON HOLD Authors: Barnes, C.O., Bjorkman, P.J. Description: B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting ant...

New page

'''Unreleased structure'''

The entry 6okp is ON HOLD

Authors: Barnes, C.O., Bjorkman, P.J.

Description: B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074
[[Category: Unreleased Structures]]
[[Category: Barnes, C.O]]
[[Category: Bjorkman, P.J]]