6on2 - Revision history

OCA at 09:24, 20 March 2024

OCA — Wed, 20 Mar 2024 09:24:50 GMT

←Older revision		Revision as of 09:24, 20 March 2024
Line 3:		Line 3:
	<SX load='6on2' size='340' side='right' viewer='molstar' caption='[[6on2]], [[Resolution\|resolution]] 3.00Å' scene=''>		<SX load='6on2' size='340' side='right' viewer='molstar' caption='[[6on2]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6on2]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus~~ pestis~~" (lehmann and neumann 1896) migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ON2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6on2]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ON2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>lon, YP_0776, EGT45_05820, NCTC144_01047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~632~~ "~~Bacillus pestis~~" ~~(Lehmann and Neumann 1896) Migula 1900])~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on2 OCA], [https://pdbe.org/6on2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6on2 RCSB], [https://www.ebi.ac.uk/pdbsum/6on2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6on2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on2 OCA], [~~http~~://pdbe.org/6on2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6on2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6on2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6on2 ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/A0A5P8YJ65_YERPE A0A5P8YJ65_YERPE] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.[HAMAP-Rule:MF_01973]
-	Substrate-bound structures of AAA+ protein translocases reveal a conserved asymmetric spiral staircase architecture wherein a sequential ATP hydrolysis cycle drives hand-over-hand substrate translocation. However, this configuration is unlikely to represent the full conformational landscape of these enzymes, as biochemical studies suggest distinct conformational states depending on the presence or absence of substrate. ~~Here, we used cryo~~-~~electron microscopy to determine structures of the Yersinia pestis Lon AAA+~~ protease in the ~~absence~~ and ~~presence of substrate, uncovering the mechanistic basis for two distinct operational modes. In the absence of substrate, Lon adopts a left~~-~~handed, "open" spiral organization with autoinhibited proteolytic active sites~~. Upon the addition of substrate, Lon undergoes a reorganization to assemble an enzymatically active, right-handed "closed" conformer with active protease sites. These findings define the mechanistic principles underlying the operational plasticity required for ~~processing diverse protein substrates.~~	+
-		+
-	~~Structural basis~~ for ~~distinct operational modes~~ and ~~protease activation in AAA+ protease Lon~~.~~,Shin M, Puchades C, Asmita A, Puri N, Adjei E, Wiseman RL, Karzai AW, Lander GC Sci Adv. 2020 May 20;6(21):eaba8404. doi:~~ 10.~~1126/sciadv.aba8404. eCollection~~, ~~2020 May~~. ~~PMID:32490208<ref>PMID:32490208</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe~~-~~citations 6on2" style="background-color~~:~~#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Endopeptidase La]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adjei, E]]	+	[[Category: Yersinia pestis]]
-	[[Category: Asmita, A]]	+	[[Category: Adjei E]]
-	[[Category: Karzai~~, A W~~]]	+	[[Category: Asmita A]]
-	[[Category: Lander~~, G C~~]]	+	[[Category: Karzai AW]]
-	[[Category: Puchades, C]]	+	[[Category: Lander GC]]
-	[[Category: Shin, M]]	+	[[Category: Puchades C]]
-	[[Category: Wiseman~~, R L]]~~	+	[[Category: Shin M]]
-	~~[[Category: Aaa+]]~~	+	[[Category: Wiseman RL]]
-	~~[[Category: Atpase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lon]]~~	+
-	~~[[Category: Mitochondrial protease~~]]	+

OCA at 08:05, 2 December 2020

OCA — Wed, 02 Dec 2020 08:05:58 GMT

←Older revision		Revision as of 08:05, 2 December 2020
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on2 OCA], [http://pdbe.org/6on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6on2 RCSB], [http://www.ebi.ac.uk/pdbsum/6on2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6on2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on2 OCA], [http://pdbe.org/6on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6on2 RCSB], [http://www.ebi.ac.uk/pdbsum/6on2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6on2 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Substrate-bound structures of AAA+ protein translocases reveal a conserved asymmetric spiral staircase architecture wherein a sequential ATP hydrolysis cycle drives hand-over-hand substrate translocation. However, this configuration is unlikely to represent the full conformational landscape of these enzymes, as biochemical studies suggest distinct conformational states depending on the presence or absence of substrate. Here, we used cryo-electron microscopy to determine structures of the Yersinia pestis Lon AAA+ protease in the absence and presence of substrate, uncovering the mechanistic basis for two distinct operational modes. In the absence of substrate, Lon adopts a left-handed, "open" spiral organization with autoinhibited proteolytic active sites. Upon the addition of substrate, Lon undergoes a reorganization to assemble an enzymatically active, right-handed "closed" conformer with active protease sites. These findings define the mechanistic principles underlying the operational plasticity required for processing diverse protein substrates.
		+
		+	Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.,Shin M, Puchades C, Asmita A, Puri N, Adjei E, Wiseman RL, Karzai AW, Lander GC Sci Adv. 2020 May 20;6(21):eaba8404. doi: 10.1126/sciadv.aba8404. eCollection, 2020 May. PMID:32490208<ref>PMID:32490208</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6on2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</SX>		</SX>

OCA at 04:07, 11 April 2020

OCA — Sat, 11 Apr 2020 04:07:07 GMT

←Older revision		Revision as of 04:07, 11 April 2020
Line 3:		Line 3:
	<SX load='6on2' size='340' side='right' viewer='molstar' caption='[[6on2]], [[Resolution\|resolution]] 3.00Å' scene=''>		<SX load='6on2' size='340' side='right' viewer='molstar' caption='[[6on2]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6on2]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ON2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6on2]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ON2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lon, YP_0776, EGT45_05820, NCTC144_01047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lon, YP_0776, EGT45_05820, NCTC144_01047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on2 OCA], [http://pdbe.org/6on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6on2 RCSB], [http://www.ebi.ac.uk/pdbsum/6on2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6on2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on2 OCA], [http://pdbe.org/6on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6on2 RCSB], [http://www.ebi.ac.uk/pdbsum/6on2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6on2 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 23:16, 6 March 2020

OCA — Fri, 06 Mar 2020 23:16:04 GMT

←Older revision		Revision as of 23:16, 6 March 2020
Line 1:		Line 1:

	==Lon Protease from Yersinia pestis with Y2853 substrate==		==Lon Protease from Yersinia pestis with Y2853 substrate==
-	<~~StructureSection~~ load='6on2' size='340' side='right'caption='[[6on2]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<SX load='6on2' size='340' side='right' viewer='molstar' caption='[[6on2]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6on2]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ON2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6on2]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ON2 FirstGlance]. <br>
Line 10:		Line 10:
	</table>		</table>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Endopeptidase La]]		[[Category: Endopeptidase La]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 18:42, 11 December 2019

OCA — Wed, 11 Dec 2019 18:42:19 GMT

←Older revision		Revision as of 18:42, 11 December 2019
Line 3:		Line 3:
	<StructureSection load='6on2' size='340' side='right'caption='[[6on2]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6on2' size='340' side='right'caption='[[6on2]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6on2]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ON2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6on2]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ON2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lon, YP_0776, EGT45_05820, NCTC144_01047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on2 OCA], [http://pdbe.org/6on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6on2 RCSB], [http://www.ebi.ac.uk/pdbsum/6on2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6on2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on2 OCA], [http://pdbe.org/6on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6on2 RCSB], [http://www.ebi.ac.uk/pdbsum/6on2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6on2 ProSAT]</span></td></tr>

OCA: Protected "6on2" [edit=sysop:move=sysop]

OCA — Wed, 01 May 2019 08:56:26 GMT

Protected "6on2" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:56, 1 May 2019

OCA: New page: ==Lon Protease from Yersinia pestis with Y2853 substrate== == Stru...

OCA — Wed, 01 May 2019 08:56:24 GMT

New page: ==Lon Protease from Yersinia pestis with Y2853 substrate== <StructureSection load='6on2' size='340' side='right'caption='6on2, resolution 3.00Å' scene=''> == Stru...

New page

==Lon Protease from Yersinia pestis with Y2853 substrate==
<StructureSection load='6on2' size='340' side='right'caption='[[6on2]], [[Resolution|resolution]] 3.00Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6on2]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON2 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ON2 FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on2 OCA], [http://pdbe.org/6on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6on2 RCSB], [http://www.ebi.ac.uk/pdbsum/6on2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6on2 ProSAT]</td></tr>
</table>
__TOC__
</StructureSection>
[[Category: Endopeptidase La]]
[[Category: Large Structures]]
[[Category: Adjei, E]]
[[Category: Asmita, A]]
[[Category: Karzai, A W]]
[[Category: Lander, G C]]
[[Category: Puchades, C]]
[[Category: Shin, M]]
[[Category: Wiseman, R L]]
[[Category: Aaa+]]
[[Category: Atpase]]
[[Category: Hydrolase]]
[[Category: Lon]]
[[Category: Mitochondrial protease]]