6or4 - Revision history

OCA at 07:15, 11 October 2023

OCA — Wed, 11 Oct 2023 07:15:34 GMT

←Older revision		Revision as of 07:15, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6or4' size='340' side='right'caption='[[6or4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6or4' size='340' side='right'caption='[[6or4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6or4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strpn Strpn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OR4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6OR4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6or4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OR4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">SP_2146 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900129:Lewis+A+antigen,+beta+anomer'>PRD_900129</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6or4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6or4 OCA], [~~http~~://pdbe.org/6or4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6or4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6or4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6or4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6or4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6or4 OCA], [https://pdbe.org/6or4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6or4 RCSB], [https://www.ebi.ac.uk/pdbsum/6or4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6or4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H2US78_STRPN A0A0H2US78_STRPN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strpn~~]]	+	[[Category: Streptococcus pneumoniae TIGR4]]
-	[[Category: Boraston~~, A B~~]]	+	[[Category: Boraston AB]]
-	[[Category: Pluvinage, B]]	+	[[Category: Pluvinage B]]
-	~~[[Category: Glycoside hydrolase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 05:46, 5 August 2020

OCA — Wed, 05 Aug 2020 05:46:41 GMT

←Older revision		Revision as of 05:46, 5 August 2020
Line 3:		Line 3:
	<StructureSection load='6or4' size='340' side='right'caption='[[6or4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6or4' size='340' side='right'caption='[[6or4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6or4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OR4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OR4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6or4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OR4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OR4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_2146 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_2146 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6or4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6or4 OCA], [http://pdbe.org/6or4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6or4 RCSB], [http://www.ebi.ac.uk/pdbsum/6or4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6or4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6or4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6or4 OCA], [http://pdbe.org/6or4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6or4 RCSB], [http://www.ebi.ac.uk/pdbsum/6or4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6or4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:42, 17 July 2019

OCA — Wed, 17 Jul 2019 12:42:34 GMT

←Older revision		Revision as of 12:42, 17 July 2019
Line 3:		Line 3:
	<StructureSection load='6or4' size='340' side='right'caption='[[6or4]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6or4' size='340' side='right'caption='[[6or4]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6or4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OR4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6or4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OR4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_2146 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6or4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6or4 OCA], [http://pdbe.org/6or4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6or4 RCSB], [http://www.ebi.ac.uk/pdbsum/6or4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6or4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6or4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6or4 OCA], [http://pdbe.org/6or4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6or4 RCSB], [http://www.ebi.ac.uk/pdbsum/6or4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6or4 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An important aspect of the interaction between the opportunistic bacterial pathogen Streptococcus pneumoniae and its human host is its ability to harvest host glycans. The pneumococcus can degrade a variety of complex glycans, including N- and O-linked glycans, glycosaminoglycans, and carbohydrate antigens, an ability that is tightly linked to the virulence of S. pneumoniae Although S. pneumoniae is known to use a sophisticated enzyme machinery to attack the human glycome, how it copes with fucosylated glycans, which are primarily histo-blood group antigens, is largely unknown. Here, we identified two pneumococcal enzymes, SpGH29C and SpGH95C, that target alpha-(1-->3/4) and alpha-(1-->2) fucosidic linkages, respectively. X-ray crystallography studies combined with functional assays revealed that SpGH29C is specific for the LewisA and LewisX antigen motifs, and that SpGH95C is specific for the H(O)-antigen motif. Together, these enzymes could defucosylate LewisY and LewisB antigens in a complementary fashion. In vitro reconstruction of glycan degradation cascades disclosed that the individual or combined activities of these enzymes expose the underlying glycan structure, promoting the complete deconstruction of a glycan that would otherwise be resistant to pneumococcal enzymes. These experiments expand our understanding of the extensive capacity of S. pneumoniae to process host glycans and the likely roles of alpha-fucosidases in this. Overall, given the importance of enzymes that initiate glycan breakdown in pneumococcal virulence, such as the neuraminidase NanA and the mannosidase SpGH92, we anticipate that the alpha-fucosidases identified here will be important factors in developing more refined models of the S. pneumoniae-host interaction.
		+
		+	Two complementary alpha-fucosidases from Streptococcus pneumoniae promote complete degradation of host-derived carbohydrate antigens.,Hobbs JK, Pluvinage B, Robb M, Smith SP, Boraston AB J Biol Chem. 2019 Jul 2. pii: RA119.009368. doi: 10.1074/jbc.RA119.009368. PMID:31266803<ref>PMID:31266803</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6or4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Strpn]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]
	[[Category: Pluvinage, B]]		[[Category: Pluvinage, B]]
	[[Category: Glycoside hydrolase]]		[[Category: Glycoside hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 05:51, 10 July 2019

OCA — Wed, 10 Jul 2019 05:51:32 GMT

←Older revision		Revision as of 05:51, 10 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6or4 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of SpGH29==
-		+	<StructureSection load='6or4' size='340' side='right'caption='[[6or4]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~: ~~Pluvinage~~, B., ~~Boraston~~, A.B.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6or4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OR4 FirstGlance]. <br>
-	~~Description: Crystal structure of SpGH29~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6or4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6or4 OCA], [http://pdbe.org/6or4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6or4 RCSB], [http://www.ebi.ac.uk/pdbsum/6or4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6or4 ProSAT]</span></td></tr>
-	[[Category: Boraston, A.B]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Boraston, A B]]
	[[Category: Pluvinage, B]]		[[Category: Pluvinage, B]]
		+	[[Category: Glycoside hydrolase]]
		+	[[Category: Hydrolase]]

OCA: Protected "6or4" [edit=sysop:move=sysop]

OCA — Fri, 10 May 2019 08:00:56 GMT

Protected "6or4" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 10 May 2019

OCA: New page: '''Unreleased structure''' The entry 6or4 is ON HOLD until Paper Publication Authors: Pluvinage, B., Boraston, A.B. Description: Crystal structure of SpGH29 [[Category: Unreleased Stru...

OCA — Fri, 10 May 2019 08:00:53 GMT

New page: '''Unreleased structure''' The entry 6or4 is ON HOLD until Paper Publication Authors: Pluvinage, B., Boraston, A.B. Description: Crystal structure of SpGH29 [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 6or4 is ON HOLD until Paper Publication

Authors: Pluvinage, B., Boraston, A.B.

Description: Crystal structure of SpGH29
[[Category: Unreleased Structures]]
[[Category: Boraston, A.B]]
[[Category: Pluvinage, B]]