6orp - Revision history

OCA at 04:10, 11 April 2020

OCA — Sat, 11 Apr 2020 04:10:02 GMT

←Older revision		Revision as of 04:10, 11 April 2020
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	<SX load='6orp' size='340' side='right' viewer='molstar' caption='[[6orp]], [[Resolution\|resolution]] 4.40Å' scene=''>		<SX load='6orp' size='340' side='right' viewer='molstar' caption='[[6orp]], [[Resolution\|resolution]] 4.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6orp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ORP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ORP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6orp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ORP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ORP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6orp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6orp OCA], [http://pdbe.org/6orp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6orp RCSB], [http://www.ebi.ac.uk/pdbsum/6orp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6orp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6orp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6orp OCA], [http://pdbe.org/6orp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6orp RCSB], [http://www.ebi.ac.uk/pdbsum/6orp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6orp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:17, 6 March 2020

OCA — Fri, 06 Mar 2020 23:17:02 GMT

←Older revision		Revision as of 23:17, 6 March 2020
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	==Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP==		==Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP==
-	<~~StructureSection~~ load='6orp' size='340' side='right'caption='[[6orp]], [[Resolution\|resolution]] 4.40Å' scene=''>	+	<SX load='6orp' size='340' side='right' viewer='molstar' caption='[[6orp]], [[Resolution\|resolution]] 4.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6orp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ORP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ORP FirstGlance]. <br>		<table><tr><td colspan='2'>[[6orp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ORP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ORP FirstGlance]. <br>
Line 24:		Line 24:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Macmu]]		[[Category: Macmu]]

OCA at 12:12, 18 December 2019

OCA — Wed, 18 Dec 2019 12:12:21 GMT

←Older revision		Revision as of 12:12, 18 December 2019
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	</div>		</div>
	<div class="pdbe-citations 6orp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6orp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gp120 3D structures\|Gp120 3D structures]]
		+	*[[Gp41 3D Structures\|Gp41 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:34, 10 July 2019

OCA — Wed, 10 Jul 2019 06:34:46 GMT

←Older revision		Revision as of 06:34, 10 July 2019
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	<StructureSection load='6orp' size='340' side='right'caption='[[6orp]], [[Resolution\|resolution]] 4.40Å' scene=''>		<StructureSection load='6orp' size='340' side='right'caption='[[6orp]], [[Resolution\|resolution]] 4.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6orp]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ORP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ORP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6orp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ORP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ORP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Macmu]]
	[[Category: Abernathy, M E]]		[[Category: Abernathy, M E]]
	[[Category: Bjorkman, P J]]		[[Category: Bjorkman, P J]]

OCA at 05:44, 12 June 2019

OCA — Wed, 12 Jun 2019 05:44:30 GMT

←Older revision		Revision as of 05:44, 12 June 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6orp is ~~ON HOLD until Paper~~ Publication	+	==Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP==
		+	<StructureSection load='6orp' size='340' side='right'caption='[[6orp]], [[Resolution\|resolution]] 4.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6orp]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ORP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ORP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6orp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6orp OCA], [http://pdbe.org/6orp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6orp RCSB], [http://www.ebi.ac.uk/pdbsum/6orp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6orp ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal models, suggesting that a vaccine that elicits these antibodies would be protective in humans. However, it has not yet been possible to induce adequate serological responses by vaccination. Here, to activate B cells that express precursors of broadly neutralizing antibodies within polyclonal repertoires, we developed an immunogen, RC1, that facilitates the recognition of the variable loop 3 (V3)-glycan patch on the envelope protein of HIV-1. RC1 conceals non-conserved immunodominant regions by the addition of glycans and/or multimerization on virus-like particles. Immunization of mice, rabbits and rhesus macaques with RC1 elicited serological responses that targeted the V3-glycan patch. Antibody cloning and cryo-electron microscopy structures of antibody-envelope complexes confirmed that immunization with RC1 expands clones of B cells that carry the anti-V3-glycan patch antibodies, which resemble precursors of human broadly neutralizing antibodies. Thus, RC1 may be a suitable priming immunogen for sequential vaccination strategies in the context of polyclonal repertoires.

-	~~Authors~~:	+	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.,Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West AP Jr, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC Nature. 2019 May 29. pii: 10.1038/s41586-019-1250-z. doi:, 10.1038/s41586-019-1250-z. PMID:31142836<ref>PMID:31142836</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6orp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Abernathy, M E]]
		+	[[Category: Bjorkman, P J]]
		+	[[Category: Gristick, H B]]
		+	[[Category: Antiviral protein]]
		+	[[Category: Antiviral protein-immune system complex]]
		+	[[Category: Cryo-em]]
		+	[[Category: Env trimer structure]]
		+	[[Category: Hiv-1 broadly-neutralizing antibody]]
		+	[[Category: Immunogen design]]
		+	[[Category: Rc1]]
		+	[[Category: V3-glycan patch]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 04:29, 29 May 2019

OCA — Wed, 29 May 2019 04:29:10 GMT

←Older revision		Revision as of 04:29, 29 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6orp is ON HOLD	+	The entry 6orp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6orp" [edit=sysop:move=sysop]

OCA — Fri, 10 May 2019 08:05:11 GMT

Protected "6orp" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:05, 10 May 2019

OCA: New page: '''Unreleased structure''' The entry 6orp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 10 May 2019 08:05:05 GMT

New page: '''Unreleased structure''' The entry 6orp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6orp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]