6ot9 - Revision history

OCA at 07:16, 11 October 2023

OCA — Wed, 11 Oct 2023 07:16:19 GMT

←Older revision		Revision as of 07:16, 11 October 2023
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	<StructureSection load='6ot9' size='340' side='right'caption='[[6ot9]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6ot9' size='340' side='right'caption='[[6ot9]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ot9]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OT9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OT9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ot9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OT9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m4b\|3m4b]], [[6ot4\|6ot4]], [[6ot7\|6ot7]], [[6ot8\|6ot8]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cybC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ot9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ot9 OCA], [https://pdbe.org/6ot9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ot9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ot9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ot9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ot9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ot9 OCA], [~~http~~://pdbe.org/6ot9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ot9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ot9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ot9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.	+	[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bailey~~, J B~~]]	+	[[Category: Bailey JB]]
-	[[Category: Esselborn, J]]	+	[[Category: Esselborn J]]
-	[[Category: Golub, E]]	+	[[Category: Golub E]]
-	[[Category: Tezcan~~, F A]]~~	+	[[Category: Tezcan FA]]
-	~~[[Category: Bimetallic]]~~	+
-	~~[[Category: Metal binding]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Protein cage]]~~	+
-	~~[[Category: Supramolecular assembly~~]]	+

OCA at 09:02, 5 February 2020

OCA — Wed, 05 Feb 2020 09:02:36 GMT

←Older revision		Revision as of 09:02, 5 February 2020
Line 3:		Line 3:
	<StructureSection load='6ot9' size='340' side='right'caption='[[6ot9]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6ot9' size='340' side='right'caption='[[6ot9]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ot9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OT9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ot9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OT9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m4b\|3m4b]], [[6ot4\|6ot4]], [[6ot7\|6ot7]], [[6ot8\|6ot8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m4b\|3m4b]], [[6ot4\|6ot4]], [[6ot7\|6ot7]], [[6ot8\|6ot8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cybC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ot9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ot9 OCA], [http://pdbe.org/6ot9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ot9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ot9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ot9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ot9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ot9 OCA], [http://pdbe.org/6ot9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ot9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ot9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ot9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.		[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many proteins exist naturally as symmetrical homooligomers or homopolymers(1). The emergent structural and functional properties of such protein assemblies have inspired extensive efforts in biomolecular design(2-5). As synthesized by ribosomes, proteins are inherently asymmetric. Thus, they must acquire multiple surface patches that selectively associate to generate the different symmetry elements needed to form higher-order architectures(1,6)-a daunting task for protein design. Here we address this problem using an inorganic chemical approach, whereby multiple modes of protein-protein interactions and symmetry are simultaneously achieved by selective, 'one-pot' coordination of soft and hard metal ions. We show that a monomeric protein (protomer) appropriately modified with biologically inspired hydroxamate groups and zinc-binding motifs assembles through concurrent Fe(3+) and Zn(2+) coordination into discrete dodecameric and hexameric cages. Our cages closely resemble natural polyhedral protein architectures(7,8) and are, to our knowledge, unique among designed systems(9-13) in that they possess tightly packed shells devoid of large apertures. At the same time, they can assemble and disassemble in response to diverse stimuli, owing to their heterobimetallic construction on minimal interprotein-bonding footprints. With stoichiometries ranging from [2 Fe:9 Zn:6 protomers] to [8 Fe:21 Zn:12 protomers], these protein cages represent some of the compositionally most complex protein assemblies-or inorganic coordination complexes-obtained by design.
		+
		+	Constructing protein polyhedra via orthogonal chemical interactions.,Golub E, Subramanian RH, Esselborn J, Alberstein RG, Bailey JB, Chiong JA, Yan X, Booth T, Baker TS, Tezcan FA Nature. 2020 Jan 22. pii: 10.1038/s41586-019-1928-2. doi:, 10.1038/s41586-019-1928-2. PMID:31969701<ref>PMID:31969701</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ot9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bailey, J B]]		[[Category: Bailey, J B]]

OCA at 15:32, 29 January 2020

OCA — Wed, 29 Jan 2020 15:32:49 GMT

←Older revision		Revision as of 15:32, 29 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ot9 is ~~ON HOLD until Paper Publication~~	+	==Bimetallic dodecameric cage design 1 (BMC1) from cytochrome cb562==
-		+	<StructureSection load='6ot9' size='340' side='right'caption='[[6ot9]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~: ~~Golub~~, E., ~~Esselborn~~, J., ~~Bailey, J~~.B., ~~Tezcan~~, F.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ot9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OT9 FirstGlance]. <br>
-	~~Description~~: ~~Bimetallic dodecameric cage design 1 (BMC1) from cytochrome cb562~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HAE:ACETOHYDROXAMIC+ACID'>HAE</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m4b\|3m4b]], [[6ot4\|6ot4]], [[6ot7\|6ot7]], [[6ot8\|6ot8]]</td></tr>
-	[[Category: ~~Tezcan~~, ~~F.A~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ot9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ot9 OCA], [http://pdbe.org/6ot9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ot9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ot9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ot9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bailey, J B]]
	[[Category: Esselborn, J]]		[[Category: Esselborn, J]]
	[[Category: Golub, E]]		[[Category: Golub, E]]
-	[[Category: ~~Bailey~~, ~~J.B~~]]	+	[[Category: Tezcan, F A]]
		+	[[Category: Bimetallic]]
		+	[[Category: Metal binding]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Protein cage]]
		+	[[Category: Supramolecular assembly]]

OCA at 04:00, 22 May 2019

OCA — Wed, 22 May 2019 04:00:53 GMT

←Older revision		Revision as of 04:00, 22 May 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ot9 is ON HOLD	+	The entry 6ot9 is ON HOLD until Paper Publication

	Authors: Golub, E., Esselborn, J., Bailey, J.B., Tezcan, F.A.		Authors: Golub, E., Esselborn, J., Bailey, J.B., Tezcan, F.A.

OCA: Protected "6ot9" [edit=sysop:move=sysop]

OCA — Fri, 10 May 2019 08:14:31 GMT

Protected "6ot9" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:14, 10 May 2019

OCA: New page: '''Unreleased structure''' The entry 6ot9 is ON HOLD Authors: Golub, E., Esselborn, J., Bailey, J.B., Tezcan, F.A. Description: Bimetallic dodecameric cage design 1 (BMC1) from cytochr...

OCA — Fri, 10 May 2019 08:14:28 GMT

New page: '''Unreleased structure''' The entry 6ot9 is ON HOLD Authors: Golub, E., Esselborn, J., Bailey, J.B., Tezcan, F.A. Description: Bimetallic dodecameric cage design 1 (BMC1) from cytochr...

New page

'''Unreleased structure'''

The entry 6ot9 is ON HOLD

Authors: Golub, E., Esselborn, J., Bailey, J.B., Tezcan, F.A.

Description: Bimetallic dodecameric cage design 1 (BMC1) from cytochrome cb562
[[Category: Unreleased Structures]]
[[Category: Tezcan, F.A]]
[[Category: Esselborn, J]]
[[Category: Golub, E]]
[[Category: Bailey, J.B]]