6oti - Revision history

OCA at 07:16, 11 October 2023

OCA — Wed, 11 Oct 2023 07:16:31 GMT

←Older revision		Revision as of 07:16, 11 October 2023
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	==Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B==		==Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B==
-	<StructureSection load='6oti' size='340' side='right'caption='[[6oti]]' scene=''>	+	<StructureSection load='6oti' size='340' side='right'caption='[[6oti]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OTI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6OTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6oti]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OTI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6oti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oti OCA], [~~http~~://pdbe.org/6oti PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6oti RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6oti PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6oti ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N84:4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide'>N84</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oti OCA], [https://pdbe.org/6oti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oti RCSB], [https://www.ebi.ac.uk/pdbsum/6oti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oti ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kota A]]		[[Category: Kota A]]
	[[Category: McKenna R]]		[[Category: McKenna R]]

OCA at 06:00, 6 May 2020

OCA — Wed, 06 May 2020 06:00:52 GMT

←Older revision		Revision as of 06:00, 6 May 2020
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-	'''Unreleased structure'''

-	~~The entry 6oti is ON HOLD until Paper Publication~~	+	==Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B==
-		+	<StructureSection load='6oti' size='340' side='right'caption='[[6oti]]' scene=''>
-	~~Authors: Kota, A., McKenna, R.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OTI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OTI FirstGlance]. <br>
-	~~Description:~~ Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6oti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oti OCA], [http://pdbe.org/6oti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oti RCSB], [http://www.ebi.ac.uk/pdbsum/6oti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oti ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Kota, A]]	+	__TOC__
-	[[Category: ~~Mckenna,~~ R]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kota A]]
		+	[[Category: McKenna R]]

OCA at 04:19, 24 July 2019

OCA — Wed, 24 Jul 2019 04:19:56 GMT

←Older revision		Revision as of 04:19, 24 July 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6oti is ON HOLD	+	The entry 6oti is ON HOLD until Paper Publication

	Authors: Kota, A., McKenna, R.		Authors: Kota, A., McKenna, R.

OCA: Protected "6oti" [edit=sysop:move=sysop]

OCA — Tue, 21 May 2019 05:46:45 GMT

Protected "6oti" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:46, 21 May 2019

OCA: New page: '''Unreleased structure''' The entry 6oti is ON HOLD Authors: Kota, A., McKenna, R. Description: Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B [[Categor...

OCA — Tue, 21 May 2019 05:46:43 GMT

New page: '''Unreleased structure''' The entry 6oti is ON HOLD Authors: Kota, A., McKenna, R. Description: Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B [[Categor...

New page

'''Unreleased structure'''

The entry 6oti is ON HOLD

Authors: Kota, A., McKenna, R.

Description: Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B
[[Category: Unreleased Structures]]
[[Category: Kota, A]]
[[Category: Mckenna, R]]