OCA at 05:59, 3 July 2019

OCA — Wed, 03 Jul 2019 05:59:14 GMT

←Older revision		Revision as of 05:59, 3 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ou3 is ~~ON HOLD~~	+	==Crystal Structure of the D478S Variant of the Myocilin Olfactomedin Domain==
-		+	<StructureSection load='6ou3' size='340' side='right'caption='[[6ou3]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ou3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OU3 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ou3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ou3 OCA], [http://pdbe.org/6ou3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ou3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ou3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ou3 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MYOC_HUMAN MYOC_HUMAN]] Congenital glaucoma;Juvenile glaucoma. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. MYOC mutations may contribute to GLC3A via digenic inheritance with CYP1B1 and/or another locus associated with the disease (PubMed:15733270).<ref>PMID:15733270</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYOC_HUMAN MYOC_HUMAN]] Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.<ref>PMID:17516541</ref> <ref>PMID:17984096</ref> <ref>PMID:18855004</ref> <ref>PMID:19188438</ref> <ref>PMID:19959812</ref> <ref>PMID:21656515</ref> <ref>PMID:23629661</ref> <ref>PMID:23897819</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hill, S E]]
		+	[[Category: Kwon, M S]]
		+	[[Category: Lieberman, R L]]
		+	[[Category: Olfactomedin myocilin beta propeller]]
		+	[[Category: Protein binding]]

OCA: Protected "6ou3" [edit=sysop:move=sysop]

OCA — Tue, 21 May 2019 05:48:28 GMT

Protected "6ou3" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:48, 21 May 2019

OCA: New page: '''Unreleased structure''' The entry 6ou3 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Tue, 21 May 2019 05:48:27 GMT

New page: '''Unreleased structure''' The entry 6ou3 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ou3 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6ou3 - Revision history

OCA at 05:59, 3 July 2019

OCA: Protected "6ou3" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6ou3 is ON HOLD Authors: Description: Category: Unreleased Structures