6ouc - Revision history

OCA at 09:25, 20 March 2024

OCA — Wed, 20 Mar 2024 09:25:17 GMT

←Older revision		Revision as of 09:25, 20 March 2024
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	<SX load='6ouc' size='340' side='right' viewer='molstar' caption='[[6ouc]], [[Resolution\|resolution]] 2.80Å' scene=''>		<SX load='6ouc' size='340' side='right' viewer='molstar' caption='[[6ouc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ouc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Snow_mountain_strain~~ Snow ~~mountain strain~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6OUC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ouc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Snow_Mountain_virus Snow Mountain virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OUC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6otf\|6otf]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=52276 Snow Mountain strain])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ouc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouc OCA], [https://pdbe.org/6ouc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ouc RCSB], [https://www.ebi.ac.uk/pdbsum/6ouc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ouc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouc OCA], [~~http~~://pdbe.org/6ouc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ouc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ouc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouc ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q80RD6_9CALI Q80RD6_9CALI]
-	Noroviruses are a leading cause of foodborne illnesses worldwide. Although GII.4 strains have been responsible for most norovirus outbreaks, the assembled virus shell structures have been available in detail for only a single strain (GI.1). We present high-resolution (2.6- to 4.1-A) cryoelectron microscopy (cryo-EM) structures of GII.4, GII.2, GI.7, and GI.1 human norovirus outbreak strain virus-like particles (VLPs). Although norovirus VLPs have been thought to exist in a single-sized assembly, our structures reveal polymorphism between and within genogroups, with small, medium, and large particle sizes observed. Using asymmetric reconstruction, we were able to resolve a Zn(2+) metal ion adjacent to the coreceptor binding site, which affected the structural stability of the shell. ~~Our structures serve as valuable templates for facilitating vaccine formulations~~.	+

-	High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.,Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L Proc Natl Acad Sci U S A. 2019 Jun 10. pii: 1903562116. doi:, 10.1073/pnas.1903562116. PMID:31182604<ref>PMID:31182604</ref>	+	==See Also==
-		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 6ouc" style~~=~~"background-color:#fffaf0;"></div>~~	+
-	~~== References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Snow ~~mountain strain~~]]	+	[[Category: Snow Mountain virus]]
-	[[Category: Diehnelt~~, C W~~]]	+	[[Category: Diehnelt CW]]
-	[[Category: Grant, T]]	+	[[Category: Grant T]]
-	[[Category: Grigorieff, N]]	+	[[Category: Grigorieff N]]
-	[[Category: Joshua-Tor, L]]	+	[[Category: Joshua-Tor L]]
-	[[Category: Jung, J]]	+	[[Category: Jung J]]
-	[[Category: Thomas~~, D R]]~~	+	[[Category: Thomas DR]]
-	~~[[Category: Caliciviridae]]~~	+
-	~~[[Category: Gii 2]]~~	+
-	~~[[Category: Norovirus]]~~	+
-	~~[[Category: Snow mountain virus]]~~	+
-	~~[[Category: Virus like particle~~]]	+

OCA at 04:13, 11 April 2020

OCA — Sat, 11 Apr 2020 04:13:57 GMT

←Older revision		Revision as of 04:13, 11 April 2020
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	<SX load='6ouc' size='340' side='right' viewer='molstar' caption='[[6ouc]], [[Resolution\|resolution]] 2.80Å' scene=''>		<SX load='6ouc' size='340' side='right' viewer='molstar' caption='[[6ouc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ouc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Snow_mountain_strain Snow mountain strain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OUC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ouc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Snow_mountain_strain Snow mountain strain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OUC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=52276 Snow Mountain strain])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=52276 Snow Mountain strain])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ouc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouc OCA], [http://pdbe.org/6ouc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouc RCSB], [http://www.ebi.ac.uk/pdbsum/6ouc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ouc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouc OCA], [http://pdbe.org/6ouc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouc RCSB], [http://www.ebi.ac.uk/pdbsum/6ouc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:18, 6 March 2020

OCA — Fri, 06 Mar 2020 23:18:22 GMT

←Older revision		Revision as of 23:18, 6 March 2020
Line 1:		Line 1:

	==Asymmetric focsued reconstruction of human norovirus GII.2 Snow Mountain Virus strain VLP asymmetric unit in T=1 symmetry==		==Asymmetric focsued reconstruction of human norovirus GII.2 Snow Mountain Virus strain VLP asymmetric unit in T=1 symmetry==
-	<~~StructureSection~~ load='6ouc' size='340' side='right'caption='[[6ouc]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<SX load='6ouc' size='340' side='right' viewer='molstar' caption='[[6ouc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ouc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Snow_mountain_strain Snow mountain strain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUC FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ouc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Snow_mountain_strain Snow mountain strain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUC FirstGlance]. <br>
Line 21:		Line 21:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Snow mountain strain]]		[[Category: Snow mountain strain]]

OCA at 06:35, 10 July 2019

OCA — Wed, 10 Jul 2019 06:35:21 GMT

←Older revision		Revision as of 06:35, 10 July 2019
Line 3:		Line 3:
	<StructureSection load='6ouc' size='340' side='right'caption='[[6ouc]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6ouc' size='340' side='right'caption='[[6ouc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ouc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ouc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Snow_mountain_strain Snow mountain strain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=52276 Snow Mountain strain])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ouc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouc OCA], [http://pdbe.org/6ouc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouc RCSB], [http://www.ebi.ac.uk/pdbsum/6ouc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ouc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouc OCA], [http://pdbe.org/6ouc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouc RCSB], [http://www.ebi.ac.uk/pdbsum/6ouc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouc ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Snow mountain strain]]
	[[Category: Diehnelt, C W]]		[[Category: Diehnelt, C W]]
	[[Category: Grant, T]]		[[Category: Grant, T]]

OCA at 07:00, 26 June 2019

OCA — Wed, 26 Jun 2019 07:00:15 GMT

←Older revision		Revision as of 07:00, 26 June 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ouc is ~~ON HOLD until Paper~~ Publication	+	==Asymmetric focsued reconstruction of human norovirus GII.2 Snow Mountain Virus strain VLP asymmetric unit in T=1 symmetry==
		+	<StructureSection load='6ouc' size='340' side='right'caption='[[6ouc]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ouc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ouc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouc OCA], [http://pdbe.org/6ouc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouc RCSB], [http://www.ebi.ac.uk/pdbsum/6ouc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouc ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Noroviruses are a leading cause of foodborne illnesses worldwide. Although GII.4 strains have been responsible for most norovirus outbreaks, the assembled virus shell structures have been available in detail for only a single strain (GI.1). We present high-resolution (2.6- to 4.1-A) cryoelectron microscopy (cryo-EM) structures of GII.4, GII.2, GI.7, and GI.1 human norovirus outbreak strain virus-like particles (VLPs). Although norovirus VLPs have been thought to exist in a single-sized assembly, our structures reveal polymorphism between and within genogroups, with small, medium, and large particle sizes observed. Using asymmetric reconstruction, we were able to resolve a Zn(2+) metal ion adjacent to the coreceptor binding site, which affected the structural stability of the shell. Our structures serve as valuable templates for facilitating vaccine formulations.

-	~~Authors~~:	+	High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.,Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L Proc Natl Acad Sci U S A. 2019 Jun 10. pii: 1903562116. doi:, 10.1073/pnas.1903562116. PMID:31182604<ref>PMID:31182604</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6ouc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Diehnelt, C W]]
		+	[[Category: Grant, T]]
		+	[[Category: Grigorieff, N]]
		+	[[Category: Joshua-Tor, L]]
		+	[[Category: Jung, J]]
		+	[[Category: Thomas, D R]]
		+	[[Category: Caliciviridae]]
		+	[[Category: Gii 2]]
		+	[[Category: Norovirus]]
		+	[[Category: Snow mountain virus]]
		+	[[Category: Virus like particle]]

OCA at 04:30, 29 May 2019

OCA — Wed, 29 May 2019 04:30:10 GMT

←Older revision		Revision as of 04:30, 29 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ouc is ON HOLD	+	The entry 6ouc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ouc" [edit=sysop:move=sysop]

OCA — Tue, 21 May 2019 05:48:55 GMT

Protected "6ouc" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:48, 21 May 2019

OCA: New page: '''Unreleased structure''' The entry 6ouc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Tue, 21 May 2019 05:48:54 GMT

New page: '''Unreleased structure''' The entry 6ouc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ouc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]