6ouu - Revision history

OCA at 09:25, 20 March 2024

OCA — Wed, 20 Mar 2024 09:25:23 GMT

←Older revision		Revision as of 09:25, 20 March 2024
Line 3:		Line 3:
	<SX load='6ouu' size='340' side='right' viewer='molstar' caption='[[6ouu]], [[Resolution\|resolution]] 4.10Å' scene=''>		<SX load='6ouu' size='340' side='right' viewer='molstar' caption='[[6ouu]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Norovirus_hu~~/~~gii~~.4/~~minerva~~/2006/~~usa~~ Norovirus hu/~~gii~~.4/~~minerva~~/2006/~~usa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6OUU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/GII.4/Minerva/2006/USA Norovirus Hu/GII.4/Minerva/2006/USA]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OUU FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~6otf~~\|~~6otf~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouu OCA], [~~http~~://pdbe.org/6ouu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ouu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ouu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouu OCA], [https://pdbe.org/6ouu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ouu RCSB], [https://www.ebi.ac.uk/pdbsum/6ouu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouu ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/R4I3T2_9CALI R4I3T2_9CALI]
-	Noroviruses are a leading cause of foodborne illnesses worldwide. Although GII.4 strains have been responsible for most norovirus outbreaks, the assembled virus shell structures have been available in detail for only a single strain (GI.1). We present high-resolution (2.6- to 4.1-A) cryoelectron microscopy (cryo-EM) structures of GII.4, GII.2, GI.7, and GI.1 human norovirus outbreak strain virus-like particles (VLPs). Although norovirus VLPs have been thought to exist in a single-sized assembly, our structures reveal polymorphism between and within genogroups, with small, medium, and large particle sizes observed. Using asymmetric reconstruction, we were able to resolve a Zn(2+) metal ion adjacent to the coreceptor binding site, which affected the structural stability of the shell. ~~Our structures serve as valuable templates for facilitating vaccine formulations~~.	+

-	High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.,Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L Proc Natl Acad Sci U S A. 2019 Jun 10. pii: 1903562116. doi:, 10.1073/pnas.1903562116. PMID:31182604<ref>PMID:31182604</ref>	+	==See Also==
-		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 6ouu" style~~=~~"background-color:#fffaf0;"></div>~~	+
-	~~== References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Norovirus hu/~~gii~~ 4/~~minerva~~/2006/~~usa~~]]	+	[[Category: Norovirus Hu/GII 4/Minerva/2006/USA]]
-	[[Category: Diehnelt~~, C W~~]]	+	[[Category: Diehnelt CW]]
-	[[Category: Grant, T]]	+	[[Category: Grant T]]
-	[[Category: Grigorieff, N]]	+	[[Category: Grigorieff N]]
-	[[Category: Joshua-Tor, L]]	+	[[Category: Joshua-Tor L]]
-	[[Category: Jung, J]]	+	[[Category: Jung J]]
-	[[Category: Thomas~~, D R]]~~	+	[[Category: Thomas DR]]
-	~~[[Category: Caliciviridae]]~~	+
-	~~[[Category: Calicivirus]]~~	+
-	~~[[Category: Gii 4]]~~	+
-	~~[[Category: Norovirus]]~~	+
-	~~[[Category: Virus like particle~~]]	+

OCA at 04:14, 11 April 2020

OCA — Sat, 11 Apr 2020 04:14:46 GMT

←Older revision		Revision as of 04:14, 11 April 2020
Line 3:		Line 3:
	<SX load='6ouu' size='340' side='right' viewer='molstar' caption='[[6ouu]], [[Resolution\|resolution]] 4.10Å' scene=''>		<SX load='6ouu' size='340' side='right' viewer='molstar' caption='[[6ouu]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_hu/gii.4/minerva/2006/usa Norovirus hu/gii.4/minerva/2006/usa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OUU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_hu/gii.4/minerva/2006/usa Norovirus hu/gii.4/minerva/2006/usa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OUU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouu OCA], [http://pdbe.org/6ouu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouu RCSB], [http://www.ebi.ac.uk/pdbsum/6ouu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouu OCA], [http://pdbe.org/6ouu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouu RCSB], [http://www.ebi.ac.uk/pdbsum/6ouu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:57, 5 March 2020

OCA — Thu, 05 Mar 2020 03:57:52 GMT

←Older revision		Revision as of 03:57, 5 March 2020
Line 1:		Line 1:

	==Symmetric reconstruction of human norovirus GII.4 Minerva strain VLP in T=4 symmetry==		==Symmetric reconstruction of human norovirus GII.4 Minerva strain VLP in T=4 symmetry==
-	<~~StructureSection~~ load='6ouu' size='340' side='right'caption='[[6ouu]], [[Resolution\|resolution]] 4.10Å' scene=''>	+	<SX load='6ouu' size='340' side='right' viewer='molstar' caption='[[6ouu]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_hu/gii.4/minerva/2006/usa Norovirus hu/gii.4/minerva/2006/usa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUU FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_hu/gii.4/minerva/2006/usa Norovirus hu/gii.4/minerva/2006/usa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUU FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Norovirus hu/gii 4/minerva/2006/usa]]		[[Category: Norovirus hu/gii 4/minerva/2006/usa]]

OCA at 06:35, 10 July 2019

OCA — Wed, 10 Jul 2019 06:35:26 GMT

←Older revision		Revision as of 06:35, 10 July 2019
Line 3:		Line 3:
	<StructureSection load='6ouu' size='340' side='right'caption='[[6ouu]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='6ouu' size='340' side='right'caption='[[6ouu]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_hu/gii.4/minerva/2006/usa Norovirus hu/gii.4/minerva/2006/usa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouu OCA], [http://pdbe.org/6ouu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouu RCSB], [http://www.ebi.ac.uk/pdbsum/6ouu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouu OCA], [http://pdbe.org/6ouu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouu RCSB], [http://www.ebi.ac.uk/pdbsum/6ouu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouu ProSAT]</span></td></tr>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Norovirus hu/gii 4/minerva/2006/usa]]
	[[Category: Diehnelt, C W]]		[[Category: Diehnelt, C W]]
	[[Category: Grant, T]]		[[Category: Grant, T]]

OCA at 07:00, 26 June 2019

OCA — Wed, 26 Jun 2019 07:00:50 GMT

←Older revision		Revision as of 07:00, 26 June 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ouu is ~~ON HOLD until Paper~~ Publication	+	==Symmetric reconstruction of human norovirus GII.4 Minerva strain VLP in T=4 symmetry==
		+	<StructureSection load='6ouu' size='340' side='right'caption='[[6ouu]], [[Resolution\|resolution]] 4.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OUU FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6otf\|6otf]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouu OCA], [http://pdbe.org/6ouu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouu RCSB], [http://www.ebi.ac.uk/pdbsum/6ouu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouu ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Noroviruses are a leading cause of foodborne illnesses worldwide. Although GII.4 strains have been responsible for most norovirus outbreaks, the assembled virus shell structures have been available in detail for only a single strain (GI.1). We present high-resolution (2.6- to 4.1-A) cryoelectron microscopy (cryo-EM) structures of GII.4, GII.2, GI.7, and GI.1 human norovirus outbreak strain virus-like particles (VLPs). Although norovirus VLPs have been thought to exist in a single-sized assembly, our structures reveal polymorphism between and within genogroups, with small, medium, and large particle sizes observed. Using asymmetric reconstruction, we were able to resolve a Zn(2+) metal ion adjacent to the coreceptor binding site, which affected the structural stability of the shell. Our structures serve as valuable templates for facilitating vaccine formulations.

-	~~Authors~~:	+	High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.,Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L Proc Natl Acad Sci U S A. 2019 Jun 10. pii: 1903562116. doi:, 10.1073/pnas.1903562116. PMID:31182604<ref>PMID:31182604</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6ouu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Diehnelt, C W]]
		+	[[Category: Grant, T]]
		+	[[Category: Grigorieff, N]]
		+	[[Category: Joshua-Tor, L]]
		+	[[Category: Jung, J]]
		+	[[Category: Thomas, D R]]
		+	[[Category: Caliciviridae]]
		+	[[Category: Calicivirus]]
		+	[[Category: Gii 4]]
		+	[[Category: Norovirus]]
		+	[[Category: Virus like particle]]

OCA at 04:30, 29 May 2019

OCA — Wed, 29 May 2019 04:30:28 GMT

←Older revision		Revision as of 04:30, 29 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ouu is ON HOLD	+	The entry 6ouu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ouu" [edit=sysop:move=sysop]

OCA — Tue, 21 May 2019 05:50:17 GMT

Protected "6ouu" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 21 May 2019

OCA: New page: '''Unreleased structure''' The entry 6ouu is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Tue, 21 May 2019 05:50:15 GMT

New page: '''Unreleased structure''' The entry 6ouu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ouu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]