6ov2 - Revision history

OCA at 07:17, 11 October 2023

OCA — Wed, 11 Oct 2023 07:17:39 GMT

←Older revision		Revision as of 07:17, 11 October 2023
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	<StructureSection load='6ov2' size='340' side='right'caption='[[6ov2]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='6ov2' size='340' side='right'caption='[[6ov2]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ov2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus~~ perfringens~~" veillon and zuber 1898~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OV2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OV2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ov2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OV2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Related_structure~~\|~~Related:]]</b></td><td class="sblockDat">[[6ov3\|6ov3~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CLDN9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), cpe ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1502 "Bacillus perfringens" Veillon and Zuber 1898])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ov2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ov2 OCA], [https://pdbe.org/6ov2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ov2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ov2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ov2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ov2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ov2 OCA], [~~http~~://pdbe.org/6ov2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ov2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ov2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ov2 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CLD9_HUMAN CLD9_HUMAN]] Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.<ref>PMID:17804490</ref> <ref>PMID:20375010</ref> ~~[[http://www.uniprot.org/uniprot/ELTB_CLOPF ELTB_CLOPF]] This enterotoxin is responsible for many cases of a mild type of food poisoning.~~	+	[https://www.uniprot.org/uniprot/CLD9_HUMAN CLD9_HUMAN] Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.<ref>PMID:17804490</ref> <ref>PMID:20375010</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ perfringens ~~veillon and zuber 1898~~]]	+	[[Category: Clostridium perfringens]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Stroud~~, R M~~]]	+	[[Category: Stroud RM]]
-	[[Category: Vecchio~~, A J]]~~	+	[[Category: Vecchio AJ]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Claudin]]~~	+
-	~~[[Category: Enterotoxin]]~~	+
-	~~[[Category: Tight junction protein]]~~	+
-	~~[[Category: Transmembrane protein~~]]	+

OCA at 11:57, 1 January 2020

OCA — Wed, 01 Jan 2020 11:57:41 GMT

←Older revision		Revision as of 11:57, 1 January 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ov2 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in closed form==
		+	<StructureSection load='6ov2' size='340' side='right'caption='[[6ov2]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ov2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OV2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6ov3\|6ov3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLDN9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), cpe ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1502 "Bacillus perfringens" Veillon and Zuber 1898])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ov2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ov2 OCA], [http://pdbe.org/6ov2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ov2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ov2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ov2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLD9_HUMAN CLD9_HUMAN]] Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.<ref>PMID:17804490</ref> <ref>PMID:20375010</ref> [[http://www.uniprot.org/uniprot/ELTB_CLOPF ELTB_CLOPF]] This enterotoxin is responsible for many cases of a mild type of food poisoning.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human pathogenic bacterium Clostridium perfringens secretes an enterotoxin (CpE) that targets claudins through its C-terminal receptor-binding domain (cCpE). Isoform-specific binding by CpE causes dissociation of claudins and tight junctions (TJs), resulting in cytotoxicity and breakdown of the gut epithelial barrier. Here, we present crystal structures of human claudin-9 (hCLDN-9) in complex with cCpE at 3.2 and 3.3 A. We show that hCLDN-9 is a high-affinity CpE receptor and that hCLDN-9-expressing cells undergo cell death when treated with CpE but not cCpE, which lacks its cytotoxic domain. Structures reveal cCpE-induced alterations to 2 epitopes known to enable claudin self-assembly and expose high-affinity interactions between hCLDN-9 and cCpE that explain isoform-specific recognition. These findings elucidate the molecular bases for hCLDN-9 selective ion permeability and binding by CpE, and provide mechanisms for how CpE disrupts gut homeostasis by dissociating claudins and TJs to affect epithelial adhesion and intercellular transport.

-	~~Authors~~:	+	Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.,Vecchio AJ, Stroud RM Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17817-17824. doi:, 10.1073/pnas.1908929116. Epub 2019 Aug 21. PMID:31434788<ref>PMID:31434788</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6ov2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bacillus perfringens veillon and zuber 1898]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Stroud, R M]]
		+	[[Category: Vecchio, A J]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Claudin]]
		+	[[Category: Enterotoxin]]
		+	[[Category: Tight junction protein]]
		+	[[Category: Transmembrane protein]]

OCA at 08:52, 17 July 2019

OCA — Wed, 17 Jul 2019 08:52:55 GMT

←Older revision		Revision as of 08:52, 17 July 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ov2 is ON HOLD	+	The entry 6ov2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ov2" [edit=sysop:move=sysop]

OCA — Tue, 21 May 2019 05:50:59 GMT

Protected "6ov2" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 21 May 2019

OCA: New page: '''Unreleased structure''' The entry 6ov2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Tue, 21 May 2019 05:50:58 GMT

New page: '''Unreleased structure''' The entry 6ov2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ov2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]