OCA at 07:22, 11 March 2020

OCA — Wed, 11 Mar 2020 07:22:47 GMT

←Older revision		Revision as of 07:22, 11 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6oz9 is ~~ON HOLD until Paper~~ Publication	+	==Ebola virus glycoprotein in complex with EBOV-520 Fab==
		+	<StructureSection load='6oz9' size='340' side='right'caption='[[6oz9]], [[Resolution\|resolution]] 3.46Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6oz9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OZ9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oz9 OCA], [http://pdbe.org/6oz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oz9 RCSB], [http://www.ebi.ac.uk/pdbsum/6oz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oz9 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structural principles underlying the composition of protective antiviral monoclonal antibody (mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic mAb cocktail against Ebola virus. We systematically analyzed the antibody repertoire in human survivors and identified a pair of potently neutralizing mAbs that cooperatively bound to the ebolavirus glycoprotein (GP). High-resolution structures revealed that in a two-antibody cocktail, molecular mimicry was a major feature of mAb-GP interactions. Broadly neutralizing mAb rEBOV-520 targeted a conserved epitope on the GP base region. mAb rEBOV-548 bound to a glycan cap epitope, possessed neutralizing and Fc-mediated effector function activities, and potentiated neutralization by rEBOV-520. Remodeling of the glycan cap structures by the cocktail enabled enhanced GP binding and virus neutralization. The cocktail demonstrated resistance to virus escape and protected non-human primates (NHPs) against Ebola virus disease. These data illuminate structural principles of antibody cooperativity with implications for development of antiviral immunotherapeutics.

-	~~Authors~~:	+	Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.,Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE Jr Immunity. 2020 Feb 18;52(2):388-403.e12. doi: 10.1016/j.immuni.2020.01.001. Epub , 2020 Feb 4. PMID:32023489<ref>PMID:32023489</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6oz9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Altman, P X]]
		+	[[Category: Crowe, J E]]
		+	[[Category: Gilchuk, P]]
		+	[[Category: Hastie, K M]]
		+	[[Category: Hui, S]]
		+	[[Category: Milligan, J C]]
		+	[[Category: Saphire, E O]]
		+	[[Category: Antibody]]
		+	[[Category: Fab]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Viral protein]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 04:10, 21 August 2019

OCA — Wed, 21 Aug 2019 04:10:43 GMT

←Older revision		Revision as of 04:10, 21 August 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6oz9 is ON HOLD	+	The entry 6oz9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6oz9" [edit=sysop:move=sysop]

OCA — Wed, 22 May 2019 04:08:43 GMT

Protected "6oz9" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:08, 22 May 2019

OCA: New page: '''Unreleased structure''' The entry 6oz9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 May 2019 04:08:42 GMT

New page: '''Unreleased structure''' The entry 6oz9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6oz9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6oz9 - Revision history

OCA at 07:22, 11 March 2020

OCA at 04:10, 21 August 2019

OCA: Protected "6oz9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6oz9 is ON HOLD Authors: Description: Category: Unreleased Structures