6p3r - Revision history

OCA at 07:22, 11 October 2023

OCA — Wed, 11 Oct 2023 07:22:41 GMT

←Older revision		Revision as of 07:22, 11 October 2023
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	<StructureSection load='6p3r' size='340' side='right'caption='[[6p3r]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6p3r' size='340' side='right'caption='[[6p3r]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6p3r]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/chicken/~~vietnam~~/32/2004(~~h5n1~~)) Influenza a virus (a/chicken/~~vietnam~~/32/2004(~~h5n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P3R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6P3R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p3r]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/chicken/Vietnam/32/2004(H5N1)) Influenza A virus (A/chicken/Vietnam/32/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P3R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~PO4~~:~~PHOSPHATE~~+~~ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-~~D-GALACTOSE'>~~GAL~~</scene>, <scene name='pdbligand=~~GLA~~:ALPHA+D-~~GALACTOSE~~'>~~GLA~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr id~~='~~NonStdRes'><td class~~=~~"sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res~~:~~]]</b~~></~~td><td class="sblockDat"~~><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=Z9N:'>Z9N</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=Z9N:alpha-D-fructofuranose'>Z9N</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=380831 Influenza A virus (A/chicken/Vietnam/32/2004(H5N1))])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p3r OCA], [https://pdbe.org/6p3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p3r RCSB], [https://www.ebi.ac.uk/pdbsum/6p3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p3r ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6p3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p3r OCA], [~~http~~://pdbe.org/6p3r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6p3r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6p3r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6p3r ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q1KHK2_9INFA Q1KHK2_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[SAAS:SAAS01039674] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]	+	[https://www.uniprot.org/uniprot/Q1KHK2_9INFA Q1KHK2_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[SAAS:SAAS01039674] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Crowe~~, J E~~]]	+	[[Category: Crowe JE]]
-	[[Category: Dong, J]]	+	[[Category: Dong J]]
-	~~[[Category: Antigen-antibody complex]]~~	+
-	~~[[Category: H5n1 vietnam]]~~	+
-	~~[[Category: Head domain]]~~	+
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Human monoclonal antibody]]~~	+
-	~~[[Category: Influenza a virus]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 11:31, 29 July 2020

OCA — Wed, 29 Jul 2020 11:31:35 GMT

←Older revision		Revision as of 11:31, 29 July 2020
Line 1:		Line 1:

	==crystal structure of human Fab H5.31 in complex with influenza A H5N1 Vietnam hemagglutinin head domain==		==crystal structure of human Fab H5.31 in complex with influenza A H5N1 Vietnam hemagglutinin head domain==
-	<StructureSection load='6p3r' size='340' side='right'caption='[[6p3r]]' scene=''>	+	<StructureSection load='6p3r' size='340' side='right'caption='[[6p3r]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P3R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6P3R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p3r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/chicken/vietnam/32/2004(h5n1)) Influenza a virus (a/chicken/vietnam/32/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P3R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6P3R FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p3r OCA], [http://pdbe.org/6p3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p3r RCSB], [http://www.ebi.ac.uk/pdbsum/6p3r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p3r ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=Z9N:'>Z9N</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=380831 Influenza A virus (A/chicken/Vietnam/32/2004(H5N1))])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p3r OCA], [http://pdbe.org/6p3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p3r RCSB], [http://www.ebi.ac.uk/pdbsum/6p3r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p3r ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q1KHK2_9INFA Q1KHK2_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[SAAS:SAAS01039674] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Crowe JE]]	+	[[Category: Crowe, J E]]
-	[[Category: Dong J]]	+	[[Category: Dong, J]]
		+	[[Category: Antigen-antibody complex]]
		+	[[Category: H5n1 vietnam]]
		+	[[Category: Head domain]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Human monoclonal antibody]]
		+	[[Category: Influenza a virus]]
		+	[[Category: Viral protein]]

OCA at 06:55, 27 May 2020

OCA — Wed, 27 May 2020 06:55:13 GMT

←Older revision		Revision as of 06:55, 27 May 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6p3r ~~is ON HOLD until Paper Publication~~	+	==crystal structure of human Fab H5.31 in complex with influenza A H5N1 Vietnam hemagglutinin head domain==
-		+	<StructureSection load='6p3r' size='340' side='right'caption='[[6p3r]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P3R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6P3R FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p3r OCA], [http://pdbe.org/6p3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p3r RCSB], [http://www.ebi.ac.uk/pdbsum/6p3r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p3r ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Crowe JE]]
		+	[[Category: Dong J]]

OCA at 04:00, 12 June 2019

OCA — Wed, 12 Jun 2019 04:00:30 GMT

←Older revision		Revision as of 04:00, 12 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6p3r is ON HOLD	+	The entry 6p3r is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6p3r" [edit=sysop:move=sysop]

OCA — Wed, 05 Jun 2019 21:11:22 GMT

Protected "6p3r" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:11, 5 June 2019

OCA: New page: '''Unreleased structure''' The entry 6p3r is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Jun 2019 21:11:20 GMT

New page: '''Unreleased structure''' The entry 6p3r is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6p3r is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]