6p64 - Revision history

OCA at 07:23, 11 October 2023

OCA — Wed, 11 Oct 2023 07:23:41 GMT

←Older revision		Revision as of 07:23, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6p64' size='340' side='right'caption='[[6p64]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='6p64' size='340' side='right'caption='[[6p64]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6p64]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P64 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p64]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P64 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.05Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HLA-A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p64 OCA], [https://pdbe.org/6p64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p64 RCSB], [https://www.ebi.ac.uk/pdbsum/6p64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p64 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p64 OCA], [https://pdbe.org/6p64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p64 RCSB], [https://www.ebi.ac.uk/pdbsum/6p64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p64 ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~B2MG_HUMAN B2MG_HUMAN~~]~~] Component of the class I major histocompatibility complex (MHC).~~ Involved in the presentation of ~~peptide~~ antigens to the immune system.	+	[https://www.uniprot.org/uniprot/Q53Z42_HUMAN Q53Z42_HUMAN] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364]

	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baker~~, B M~~]]	+	[[Category: Baker BM]]
-	[[Category: Devlin~~, J R]]~~	+	[[Category: Devlin JR]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Neoantigen]]~~	+
-	~~[[Category: Peptide/mhc]]~~	+
-	~~[[Category: T cell receptor~~]]	+

OCA at 07:09, 16 March 2022

OCA — Wed, 16 Mar 2022 07:09:46 GMT

←Older revision		Revision as of 07:09, 16 March 2022
Line 1:		Line 1:

-	==~~n/a~~==	+	==Alpha-beta TCR Binding to Neoantigen KQWLVWLFL Presented by HLA-A206==
-	<StructureSection load='6p64' size='340' side='right'caption='[[6p64]]' scene=''>	+	<StructureSection load='6p64' size='340' side='right'caption='[[6p64]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P64 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p64]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P64 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p64 OCA], [https://pdbe.org/6p64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p64 RCSB], [https://www.ebi.ac.uk/pdbsum/6p64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p64 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p64 OCA], [https://pdbe.org/6p64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p64 RCSB], [https://www.ebi.ac.uk/pdbsum/6p64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p64 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: N/a]]	+	[[Category: Baker, B M]]
		+	[[Category: Devlin, J R]]
		+	[[Category: Immune system]]
		+	[[Category: Neoantigen]]
		+	[[Category: Peptide/mhc]]
		+	[[Category: T cell receptor]]

OCA at 15:17, 8 June 2021

OCA — Tue, 08 Jun 2021 15:17:13 GMT

←Older revision		Revision as of 15:17, 8 June 2021
Line 3:		Line 3:
	<StructureSection load='6p64' size='340' side='right'caption='[[6p64]]' scene=''>		<StructureSection load='6p64' size='340' side='right'caption='[[6p64]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P64 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6P64 FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P64 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p64 OCA], [~~http~~://pdbe.org/6p64 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6p64 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6p64 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6p64 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p64 OCA], [https://pdbe.org/6p64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p64 RCSB], [https://www.ebi.ac.uk/pdbsum/6p64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p64 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:54, 20 July 2020

OCA — Mon, 20 Jul 2020 08:54:37 GMT

←Older revision		Revision as of 08:54, 20 July 2020
Line 6:		Line 6:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p64 OCA], [http://pdbe.org/6p64 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p64 RCSB], [http://www.ebi.ac.uk/pdbsum/6p64 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p64 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p64 OCA], [http://pdbe.org/6p64 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p64 RCSB], [http://www.ebi.ac.uk/pdbsum/6p64 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p64 ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: N/a]]		[[Category: N/a]]

OCA at 06:27, 3 June 2020

OCA — Wed, 03 Jun 2020 06:27:16 GMT

←Older revision		Revision as of 06:27, 3 June 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6p64 ~~is ON HOLD until Paper Publication~~	+	==n/a==
-		+	<StructureSection load='6p64' size='340' side='right'caption='[[6p64]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P64 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6P64 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p64 OCA], [http://pdbe.org/6p64 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p64 RCSB], [http://www.ebi.ac.uk/pdbsum/6p64 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p64 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: N/a]]

OCA: Protected "6p64" [edit=sysop:move=sysop]

OCA — Wed, 12 Jun 2019 04:03:28 GMT

Protected "6p64" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:03, 12 June 2019

OCA: New page: '''Unreleased structure''' The entry 6p64 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jun 2019 04:03:26 GMT

New page: '''Unreleased structure''' The entry 6p64 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6p64 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]