6p6x - Revision history

OCA at 07:24, 11 October 2023

OCA — Wed, 11 Oct 2023 07:24:06 GMT

←Older revision		Revision as of 07:24, 11 October 2023
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	<StructureSection load='6p6x' size='340' side='right'caption='[[6p6x]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='6p6x' size='340' side='right'caption='[[6p6x]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6p6x]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arcb4 Arcb4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P6X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6P6X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p6x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aliarcobacter_butzleri_RM4018 Aliarcobacter butzleri RM4018]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P6X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abu_1752 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=367737 ARCB4])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6p6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p6x OCA], [~~http~~://pdbe.org/6p6x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6p6x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6p6x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6p6x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p6x OCA], [https://pdbe.org/6p6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p6x RCSB], [https://www.ebi.ac.uk/pdbsum/6p6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p6x ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8EVM5_ALIB4 A8EVM5_ALIB4]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6p6x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6p6x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arcb4~~]]	+	[[Category: Aliarcobacter butzleri RM4018]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Catterall~~, W A~~]]	+	[[Category: Catterall WA]]
-	[[Category: El-Din~~, T M.Gamal~~]]	+	[[Category: Gamal El-Din TM]]
-	[[Category: McCord, E]]	+	[[Category: McCord E]]
-	[[Category: Tonggu, L]]	+	[[Category: Tonggu L]]
-	[[Category: Wang, L]]	+	[[Category: Wang L]]
-	[[Category: Wisedchaisri, G]]	+	[[Category: Wisedchaisri G]]
-	[[Category: Zheng, N]]	+	[[Category: Zheng N]]
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Ion transport protein]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Metal transport~~]]	+

OCA at 06:43, 21 August 2019

OCA — Wed, 21 Aug 2019 06:43:08 GMT

←Older revision		Revision as of 06:43, 21 August 2019
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	<StructureSection load='6p6x' size='340' side='right'caption='[[6p6x]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='6p6x' size='340' side='right'caption='[[6p6x]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6p6x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P6X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p6x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcb4 Arcb4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P6X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abu_1752 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=367737 ARCB4])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p6x OCA], [http://pdbe.org/6p6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p6x RCSB], [http://www.ebi.ac.uk/pdbsum/6p6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p6x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p6x OCA], [http://pdbe.org/6p6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p6x RCSB], [http://www.ebi.ac.uk/pdbsum/6p6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p6x ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arcb4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Catterall, W A]]		[[Category: Catterall, W A]]

OCA at 16:42, 14 August 2019

OCA — Wed, 14 Aug 2019 16:42:31 GMT

←Older revision		Revision as of 16:42, 14 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6p6x is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of voltage-gated sodium channel NavAb G94C/Q150C mutant in the activated state==
		+	<StructureSection load='6p6x' size='340' side='right'caption='[[6p6x]], [[Resolution\|resolution]] 2.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6p6x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P6X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p6x OCA], [http://pdbe.org/6p6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p6x RCSB], [http://www.ebi.ac.uk/pdbsum/6p6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p6x ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Voltage-gated sodium (NaV) channels initiate action potentials in nerve, muscle, and other electrically excitable cells. The structural basis of voltage gating is uncertain because the resting state exists only at deeply negative membrane potentials. To stabilize the resting conformation, we inserted voltage-shifting mutations and introduced a disulfide crosslink in the VS of the ancestral bacterial sodium channel NaVAb. Here, we present a cryo-EM structure of the resting state and a complete voltage-dependent gating mechanism. The S4 segment of the VS is drawn intracellularly, with three gating charges passing through the transmembrane electric field. This movement forms an elbow connecting S4 to the S4-S5 linker, tightens the collar around the S6 activation gate, and prevents its opening. Our structure supports the classical "sliding helix" mechanism of voltage sensing and provides a complete gating mechanism for voltage sensor function, pore opening, and activation-gate closure based on high-resolution structures of a single sodium channel protein.

-	~~Authors~~:	+	Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.,Wisedchaisri G, Tonggu L, McCord E, Gamal El-Din TM, Wang L, Zheng N, Catterall WA Cell. 2019 Aug 8;178(4):993-1003.e12. doi: 10.1016/j.cell.2019.06.031. Epub 2019 , Jul 25. PMID:31353218<ref>PMID:31353218</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6p6x" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Catterall, W A]]
		+	[[Category: El-Din, T M.Gamal]]
		+	[[Category: McCord, E]]
		+	[[Category: Tonggu, L]]
		+	[[Category: Wang, L]]
		+	[[Category: Wisedchaisri, G]]
		+	[[Category: Zheng, N]]
		+	[[Category: Ion channel]]
		+	[[Category: Ion transport protein]]
		+	[[Category: Membrane protein]]
		+	[[Category: Metal transport]]

OCA at 05:12, 26 June 2019

OCA — Wed, 26 Jun 2019 05:12:59 GMT

←Older revision		Revision as of 05:12, 26 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6p6x is ON HOLD	+	The entry 6p6x is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6p6x" [edit=sysop:move=sysop]

OCA — Wed, 12 Jun 2019 04:05:25 GMT

Protected "6p6x" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:05, 12 June 2019

OCA: New page: '''Unreleased structure''' The entry 6p6x is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jun 2019 04:05:23 GMT

New page: '''Unreleased structure''' The entry 6p6x is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6p6x is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]